Results 21 to 30 of about 7,724 (232)

Tropoelastin Implants That Accelerate Wound Repair [PDF]

Advanced Healthcare Materials, 2018
AbstractA novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair.
Suzanne M. Mithieux, Behnaz Aghaei‐Ghareh‐Bolagh, Leping Yan, Kekini V. Kuppan, Yiwei Wang, Francia Garces‐Suarez, Zhe Li, Peter Maitz, Elizabeth A. Carter, Christina Limantoro, Wojciech Chrzanowski, David Cookson, Alan Riboldi‐Tunnicliffe, Clair Baldock, Kosuke Ohgo, Kristin K. Kumashiro, Glenn A. Edwards, Anthony S. Weiss   +17 more
openalex   +4 more sources

Biochemistry of tropoelastin [PDF]

European Journal of Biochemistry, 1998
Elastic fibres are an important component of the extracellular matrix and are made of two major components : the more abundant cross‐linked elastic protein elastin and the multi‐component microfibrils. The biosynthesis of elastic fibres is a complex process involving the interplay of many diverse proteins and genes with elastin as the major component ...
B, Vrhovski, A S, Weiss
openaire   +2 more sources

Toll-like receptor 2 activation and serum amyloid A regulate smooth muscle cell extracellular matrix. [PDF]

PLoS ONE, 2017
Smooth muscle cells contribute to extracellular matrix remodeling during atherogenesis. De-differentiated, synthetic smooth muscle cells are involved in processes of migration, proliferation and changes in expression of extracellular matrix components ...
Stephanie E Seidl, Lawrence G Pessolano, Christopher A Bishop, Michael Best, Celeste B Rich, Phillip J Stone, Barbara M Schreiber   +6 more
doaj   +1 more source

Fibrous Scaffolds From Elastin-Based Materials

Frontiers in Bioengineering and Biotechnology, 2021
Current cutting-edge strategies in biomaterials science are focused on mimicking the design of natural systems which, over millions of years, have evolved to exhibit extraordinary properties. Based on this premise, one of the most challenging tasks is to
Jose Carlos Rodriguez-Cabello, Jose Carlos Rodriguez-Cabello, Israel Gonzalez De Torre, Israel Gonzalez De Torre, Miguel González-Pérez, Miguel González-Pérez, Fernando González-Pérez, Fernando González-Pérez, Irene Montequi, Irene Montequi   +9 more
doaj   +1 more source

Trends in the Development of Tailored Elastin-Like Recombinamer–Based Porous Biomaterials for Soft and Hard Tissue Applications

Frontiers in Materials, 2021
Porous biomaterials are of significant interest in a variety of biomedical applications as they enable the diffusion of nutrients and gases as well as the removal of metabolic waste from implants.
Lubinda Mbundi, Lubinda Mbundi, Miguel González-Pérez, Fernando González-Pérez, Diana Juanes-Gusano, José Carlos Rodríguez-Cabello   +5 more
doaj   +1 more source

Improved tropoelastin synthesis in the skin by codon optimization and nucleotide modification of tropoelastin-encoding synthetic mRNA

Molecular Therapy: Nucleic Acids, 2023
Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimization ...
Sonia Golombek, Thomas Hoffmann, Ludmilla Hann, Markus Mandler, Sabine Schmidhuber, Josefin Weber, Young-Tae Chang, Roman Mehling, Andrea Ladinig, Christian Knecht, Johanna Leyens, Christian Schlensak, Hans Peter Wendel, Achim Schneeberger, Meltem Avci-Adali   +14 more
doaj   +1 more source

Tropoelastin-Pretreated Exosomes from Adipose-Derived Stem Cells Improve the Synthesis of Cartilage Matrix and Alleviate Osteoarthritis

Journal of Functional Biomaterials, 2023
Mesenchymal stem cells (MSCs) have recently been widely used to treat osteoarthritis (OA). Our prior research shows that tropoelastin (TE) increases MSC activity and protects knee cartilage from OA-related degradation.
Shuo Meng, Cong Tang, Muhai Deng, Jie Yuan, Yanli Fan, Shasha Gao, Yong Feng, Junjun Yang, Cheng Chen   +8 more
doaj   +1 more source

Infusion of Induced Regulatory T Cells Alleviates Atherosclerosis by Reducing Pathological Macrophage-Like Vascular Smooth Muscle Cells. [PDF]

MedComm (2020)
Macrophage‐like phenotype switched VSMCs increase the trans‐differentiation of nature regulatory T cells (nTregs) to pathogenic Th17 cells. Induced regulatory T cells (iTregs) are stable and can inhibit the macrophage‐like phenotypic switching of VSMCs, as well as reduce pathological VSMC migration and survival.
Zhang X, Chen Y, Ling Y, Wu L, Liu D, Wang L, Liu Y, Shi G, Zhou B, Hao B, Zheng Z, Yu S, Wang M, Zhao J, Zeng D, Wang J, Lu Y, Tao J, Xia W, Zheng SG, Qian X.   +20 more
europepmc   +2 more sources

Radioimmunological identification of tropoelastin [PDF]

Biochemical Journal, 1976
Antiserum was prepared in sheep against insoluble elastin isolated from embryonic-chick aortae. In an indirect immunoprecipitation test, the antiserum reacted quantitatively with small amounts of radioactively labelled purified tropoelastin prepared from embryonic-chick aortae. The antiserum did not cross-react with chick procollagen, and the antiserum
P, Christner, M, Dixon, A, Cywinski, J, Rosenbloom   +3 more
openaire   +2 more sources

Autosomal Recessive Cutis Laxa 1C Mutations Disrupt the Structure and Interactions of Latent TGFβ Binding Protein-4

Frontiers in Genetics, 2021
Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of TGFβ and assembly of elastic fibre proteins, fibrillin-1 and tropoelastin.
Yasmene F. Alanazi, Michael P. Lockhart-Cairns, Stuart A. Cain, Thomas A. Jowitt, Anthony S. Weiss, Anthony S. Weiss, Anthony S. Weiss, Clair Baldock   +7 more
doaj   +1 more source