Molecular Therapy: Nucleic Acids, 2023 Loss of elastin due to aging, disease, or injury can lead to impaired tissue function. In this study, de novo tropoelastin (TE) synthesis is investigated in vitro and in vivo using different TE-encoding synthetic mRNA variants after codon optimization ...
Sonia Golombek +14 more
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Improved Wound Closure Rates and Mechanical Properties Resembling Native Skin in Murine Diabetic Wounds Treated with a Tropoelastin and Collagen Wound Healing Device [PDF]
bioRxiv, 2020 Chronic wounds in patients suffering from type II diabetes mellitus (DMII) where wounds remain open with a complicated pathophysiology, healing, and recovery process is a public health concern. Normal wound healing plays a critical role in wound closure,
Robert S. Kellar +9 more
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Dill Extract Induces Elastic Fiber Neosynthesis and Functional Improvement in the Ascending Aorta of Aged Mice with Reversal of Age-Dependent Cardiac Hypertrophy and Involvement of Lysyl Oxidase-Like-1 [PDF]
Biomolecules, 2020 Elastic fibers (90% elastin, 10% fibrillin-rich microfibrils) are synthesized only in early life and adolescence mainly by the vascular smooth muscle cells through the cross-linking of its soluble precursor, tropoelastin.
Wassim Fhayli +7 more
doaj +4 more sources
Tropoelastin Implants That Accelerate Wound Repair [PDF]
Advanced Healthcare Materials, 2018 AbstractA novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair.
Suzanne M. Mithieux +17 more
openaire +3 more sources
Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly [PDF]
, 2015 The assembly of the tropoelastin monomer into elastin is vital for conferring elasticity on blood vessels, skin, and lungs. Tropoelastin has dual needs for flexibility and structure in self-assembly.
Baldock, Clair +5 more
core +3 more sources
Stochastic simulations of self-organized elastogenesis in the developing lung. [PDF]
PLoS Computational Biology, 2023 In the normal lung, the dominant cable is an elastic "line element" composed of elastin fibers bound to a protein scaffold. The cable line element maintains alveolar geometry by balancing surface forces within the alveolus and changes in lung volume with
Xiru Fan +5 more
doaj +2 more sources
Multiple chick tropoelastin mRNAs
Biochemical and Biophysical Research Communications, 1988 Several overlapping chick tropoelastin cDNAs were isolated from a lambda gt11 cDNA library constructed from whole 10 day chick embryo total RNA. Comparison of the nucleotide sequence of the 2.3 kb tropoelastin cDNA to the sequences published by Bressan et al. (1) and Tokimitsu et al.
Valerie J. Baule, Judith Ann Foster
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A novel tropoelastin-based resorbable surgical mesh for pelvic organ prolapse repair
Materials Today Bio, 2020 Pelvic organ prolapse is a common condition that affects 1 in 4 women across all age groups. It is mainly caused by vaginal birth injury and can be exacerbated by obesity and increased age.
B. Aghaei-Ghareh-Bolagh +8 more
doaj +2 more sources
Coarse-grained model of tropoelastin self-assembly into nascent fibrils
Materials Today Bio, 2019 Elastin is the dominant building block of elastic fibers that impart structural integrity and elasticity to a range of important tissues, including the lungs, blood vessels, and skin.
A. Tarakanova +3 more
doaj +2 more sources
Photocrosslinkable Gelatin/Tropoelastin Hydrogel Adhesives for Peripheral Nerve Repair [PDF]
Tissue Engineering. Part A, 2018 Suturing peripheral nerve transections is the predominant therapeutic strategy for nerve repair. However, the use of sutures leads to scar tissue formation, hinders nerve regeneration, and prevents functional recovery.
Jonathan R. Soucy +8 more
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