Results 21 to 30 of about 7,144 (202)

Tropoelastin Improves Post-Infarct Cardiac Function. [PDF]

Circ Res, 2023
Background: Myocardial infarction (MI) is among the leading causes of death worldwide. Following MI, necrotic cardiomyocytes are replaced by a stiff collagen-rich scar. Compared to collagen, the extracellular matrix protein elastin has high elasticity and may have more favorable properties within the cardiac scar.
Hume RD, Kanagalingam S, Deshmukh T, Chen S, Mithieux SM, Rashid FN, Roohani I, Lu J, Doan T, Graham D, Clayton ZE, Slaughter E, Kizana E, Stempien-Otero AS, Brown P, Thomas L, Weiss AS, Chong JJH.   +17 more
europepmc   +3 more sources

Incorporation of Human Recombinant Tropoelastin into Silk Fibroin Membranes with the View to Repairing Bruch’s Membrane

Journal of Functional Biomaterials, 2015
Bombyx mori silk fibroin membranes provide a potential delivery vehicle for both cells and extracellular matrix (ECM) components into diseased or injured tissues. We have previously demonstrated the feasibility of growing retinal pigment epithelial cells
Audra M. A. Shadforth, Shuko Suzuki, Raphaelle Alzonne, Grant A. Edwards, Neil A. Richardson, Traian V. Chirila, Damien G. Harkin   +6 more
doaj   +1 more source

Multifunctional SilkTropoelastin Biomaterial Systems [PDF]

Israel Journal of Chemistry, 2013
AbstractNew multifunctional, degradable, polymeric biomaterial systems would provide versatile platforms to address cell and tissue needs in both in vitro and in vivo environments. While protein‐based composites or alloys are the building blocks of biological organisms, similar systems have not been largely exploited, to date, to generate ad hoc ...
Chiara E, Ghezzi, Jelena, Rnjak-Kovacina, Anthony S, Weiss, David L, Kaplan   +3 more
openaire   +2 more sources

Transforming Growth Factor β1 and Tropoelastin Expression in Uterine Prolapse

Indonesian Journal of Obstetrics and Gynecology, 2016
Objective: To know the correlation of the expression of transforming growth factor beta (TGF-β1) and tropoelastin in uterine prolapse. Method: A cross-sectional study of 30 subjects suffered from uterine prolapse in the Department of Obstetrics and ...
Alvilusia Alvilusia, Amir Fauzi, Azhari Azhari, Wresnindyatsih Wresnindyatsih, Irsan Saleh   +4 more
doaj   +1 more source

Subtle balance of tropoelastin molecular shape and flexibility regulates dynamics and hierarchical assembly [PDF]

, 2015
The assembly of the tropoelastin monomer into elastin is vital for conferring elasticity on blood vessels, skin, and lungs. Tropoelastin has dual needs for flexibility and structure in self-assembly.
Baldock, Clair, Buehler, Markus J, Tarakanova, Anna, Weiss, Anthony S., Wise, Steven G., Yeo, Giselle C.   +5 more
core   +1 more source

Allysine modifications perturb tropoelastin structure and mobility on a local and global scale

Matrix Biology Plus, 2019
Elastin provides elastic tissues with resilience through stretch and recoil cycles, and is primarily made of its extensively cross-linked monomer, tropoelastin.
Jazmin Ozsvar, Anna Tarakanova, Richard Wang, Markus J. Buehler, Anthony S. Weiss   +4 more
doaj   +1 more source

The changes in chemical composition during development of the bovine nuchal ligament [PDF]

, 1967
Whole bovine nuchal ligaments, or portions thereof (in the case of commercially valuable animals), were obtained from 45 animals (28 fetal and 17 postnatal) ranging in age from 110 days of gestation to 10 yr. Insoluble elastin was quantitatively prepared
Cleary, E. G., Jackson, D. S., Sandberg, L. B.   +2 more
core   +3 more sources

Conformational and thermal characterization of a synthetic peptidic fragment inspired from human tropoelastin: Signature of the amyloid fibers [PDF]

, 2014
Objectives : This work deals with the conformational and thermal characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin by the matrix metalloproteinase-12 that was shown to form amyloid-like fibres under ...
Bochicchio, Brigida, Dandurand, Jany, Lacabanne, Colette, Lacoste-Ferré, Marie-Hélène, Pepe, Antonietta, Samouillan, Valérie   +5 more
core   +4 more sources

Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing [PDF]

, 2017
Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sliding
A Heinz, AJ Viera, B Vrhovski, C Thorpe, C Thorpe, CT Thorpe, CT Thorpe, CT Thorpe, CT Thorpe, CT Thorpe, CT Thorpe, D Bedell-Hogan, EL Batson, F Ramirez, H Birch, H Oxlund, H Tempfer, HL Birch, IM Braverman, J Fallon, JA Foster, JA Foster, JA Pierce, JE Wagenseil, JF Innes, K Kubo, KD Smith, L Nimeskern, L Robert, L Robert, M Akagawa, M Benjamin, M Luisetti, MJ Sherratt, P Berens, P Kannus, PPY Lui, R Alexander, R Ker, SA Fenwick, SE Greenwald, SG Dakin, T Watanabe, TB Csóka, TC Lee, TM Grant, TM Grant, Z Gunja-Smith, Z Liu   +48 more
core   +4 more sources

Tropoelastin Implants That Accelerate Wound Repair [PDF]

Advanced Healthcare Materials, 2018
AbstractA novel, pure, synthetic material is presented that promotes the repair of full‐thickness skin wounds. The active component is tropoelastin and leverages its ability to promote new blood vessel formation and its cell recruiting properties to accelerate wound repair.
Suzanne M. Mithieux, Behnaz Aghaei‐Ghareh‐Bolagh, Leping Yan, Kekini V. Kuppan, Yiwei Wang, Francia Garces‐Suarez, Zhe Li, Peter K. Maitz, Elizabeth A. Carter, Christina Limantoro, Wojciech Chrzanowski, David Cookson, Alan Riboldi‐Tunnicliffe, Clair Baldock, Kosuke Ohgo, Kristin K. Kumashiro, Glenn Edwards, Anthony S. Weiss   +17 more
openaire   +2 more sources