Allysine modifications perturb tropoelastin structure and mobility on a local and global scale
Matrix Biology Plus, 2019 Elastin provides elastic tissues with resilience through stretch and recoil cycles, and is primarily made of its extensively cross-linked monomer, tropoelastin.
Jazmin Ozsvar +4 more
doaj +2 more sources
RiboScreenTM Technology Delivers a Ribosomal Target and a Small-Molecule Ligand for Ribosome Editing to Boost the Production Levels of Tropoelastin, the Monomeric Unit of Elastin [PDF]
Int J Mol SciElastin, a key structural protein essential for the elasticity of the skin and elastogenic tissues, degrades with age. Replenishing elastin holds promise for anti-aging cosmetics and the supplementation of elastic activities of the cardiovascular system.
Bjoern Wimmer +25 more
semanticscholar +2 more sources
Impact of N‐linked glycans on the dual short fibulin/LTBP‐4 axes regulating elastogenesis [PDF]
The FEBS Journal, Volume 292, Issue 21, Page 5676-5696, November 2025.Elastic fiber assembly is orchestrated by multiple glycoproteins. We delineate the molecular basis of two key axes involved in elastic fiber formation—LTBP‐4L/fibulin‐4 and LTBP‐4S/fibulin‐5. We show that N‐linked glycans on these glycoproteins regulate their interactions and conformations, both of which are critical aspects in elastic fiber formation.
Valentin Nelea +8 more
wiley +2 more sources
Protein malnutrition impairs skin elasticity in hairless mice by downregulating tropoelastin, fibrillin-1, and lysyl oxidase-like protein-1 [PDF]
Beni-Suef University Journal of Basic and Applied SciencesBackground Malnutrition is a known cause of skin disorders, but the genetic mechanisms linking it to dermal dysfunctions, particularly skin elasticity, are not fully understood.
Toshihiro KOBAYASHI +3 more
doaj +2 more sources
, 2012 A serum antibody, specific for tropoelastin was developed in rabbits. The tropoelastin antigen was extracted from the aortas of swine raised on a copper-deficient diet. The amino acid composition and molecular weight of the tropoelastin antigen was determined through amino acid analysis and disc electrophoresis.
Snook, Valerie Kim
openalex +2 more sources
Silk–tropoelastin protein films for nerve guidance [PDF]
Acta Biomaterialia, 2014 Peripheral nerve regeneration may be enhanced through the use of biodegradable thin film biomaterials as highly tuned inner nerve conduit liners. Dorsal root ganglion neuron and Schwann cell responses were studied on protein films comprising silk fibroin blended with recombinant human tropoelastin protein.
James D. White +3 more
openalex +3 more sources
Infusion of Induced Regulatory T Cells Alleviates Atherosclerosis by Reducing Pathological Macrophage‐Like Vascular Smooth Muscle Cells [PDF]
MedComm, Volume 6, Issue 11, November 2025.Macrophage‐like phenotype switched VSMCs increase the trans‐differentiation of nature regulatory T cells (nTregs) to pathogenic Th17 cells. Induced regulatory T cells (iTregs) are stable and can inhibit the macrophage‐like phenotypic switching of VSMCs, as well as reduce pathological VSMC migration and survival.
Ximei Zhang +20 more
wiley +2 more sources
Tropoelastin is a Flexible Molecule that Retains its Canonical Shape
Macromolecular Bioscience, 2018 Tropoelastin is the dominant building block of elastic fibers, which form a major component of the extracellular matrix, providing structural support to tissues and imbuing them with elasticity and resilience.
Anna Tarakanova +4 more
openalex +3 more sources
Biological & Pharmaceutical Bulletin, 2017 The cross-linking of elastin by lysyl oxidase (LOX) family members is essential for the integrity and elasticity of elastic fibers, which play an important role in the characteristic resilience of various tissues. However, the temporal sequence of oxidation by LOX during elastic fiber formation is still incompletely understood.
Fumiaki, Sato +5 more
openaire +4 more sources
Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells [PDF]
Nature CommunicationsMicrofibril-associated glycoprotein 4 (MFAP4) is a 36-kDa extracellular matrix glycoprotein with critical roles in organ fibrosis, chronic obstructive pulmonary disease, and cardiovascular disorders, including aortic aneurysms.
Michael R. Wozny +6 more
doaj +2 more sources