Journal of Functional Biomaterials, 2015 Bombyx mori silk fibroin membranes provide a potential delivery vehicle for both cells and extracellular matrix (ECM) components into diseased or injured tissues. We have previously demonstrated the feasibility of growing retinal pigment epithelial cells
Audra M. A. Shadforth +6 more
doaj +1 more source
Multifunctional SilkTropoelastin Biomaterial Systems [PDF]
Israel Journal of Chemistry, 2013 AbstractNew multifunctional, degradable, polymeric biomaterial systems would provide versatile platforms to address cell and tissue needs in both in vitro and in vivo environments. While protein‐based composites or alloys are the building blocks of biological organisms, similar systems have not been largely exploited, to date, to generate ad hoc ...
Chiara E, Ghezzi +3 more
openaire +2 more sources
Transforming Growth Factor β1 and Tropoelastin Expression in Uterine Prolapse
Indonesian Journal of Obstetrics and Gynecology, 2016 Objective: To know the correlation of the expression of transforming growth factor beta (TGF-β1) and tropoelastin in uterine prolapse. Method: A cross-sectional study of 30 subjects suffered from uterine prolapse in the Department of Obstetrics and ...
Alvilusia Alvilusia +4 more
doaj +1 more source
Allysine modifications perturb tropoelastin structure and mobility on a local and global scale
Matrix Biology Plus, 2019 Elastin provides elastic tissues with resilience through stretch and recoil cycles, and is primarily made of its extensively cross-linked monomer, tropoelastin.
Jazmin Ozsvar +4 more
doaj +1 more source
Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice [PDF]
, 2006 Elastic fibers provide tissues with elasticity which is critical to the function of arteries, lungs, skin, and other dynamic organs. Loss of elasticity is a major contributing factor in aging and diseases.
Broekelmann, Thomas J +10 more
core +3 more sources
Physiological Reports, 2020 Pelvic organ prolapse (POP) decreases quality of life for many women, but its pathophysiology is poorly understood. We have previously shown that Lysyl oxidase‐like 1 knockout (Loxl1 KO) mice reliably prolapse with age and increased parity, similar to ...
Slater A. Jameson +8 more
doaj +1 more source
Conformational and thermal characterization of a synthetic peptidic fragment inspired from human tropoelastin: Signature of the amyloid fibers [PDF]
, 2014 Objectives : This work deals with the conformational and thermal characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin by the matrix metalloproteinase-12 that was shown to form amyloid-like fibres under ...
Bochicchio, Brigida +5 more
core +4 more sources
Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. [PDF]
, 2017 Aims: Mast cells are versatile innate immune cells and are reported to promote vascular inflammation and neointimal lesion formation, thereby contributing to the development of vascular stenosis and atherosclerosis.
Kennedy, Simon +3 more
core +8 more sources
Coarse-grained model of tropoelastin self-assembly into nascent fibrils
Materials Today Bio, 2019 Elastin is the dominant building block of elastic fibers that impart structural integrity and elasticity to a range of important tissues, including the lungs, blood vessels, and skin.
A. Tarakanova +3 more
doaj +1 more source
Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid [PDF]
, 2009 Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis. The keloid matrix contains excess collagen and glycosaminoglycans (GAGs), but lacks elastic fiber. However, the roles of these matrix components in
Ikeda, Mika +10 more
core +1 more source