Results 51 to 60 of about 9,068 (269)

Imaging of Dysfunctional Elastogenesis in Atherosclerosis Using an Improved Gadolinium-Based Tetrameric MRI Probe Targeted to Tropoelastin

Journal of Medicinal Chemistry, 2021
Dysfunctional elastin turnover plays a major role in the progression of atherosclerotic plaques. Failure of tropoelastin cross-linking into mature elastin leads to the accumulation of tropoelastin within the growing plaque, increasing its instability ...
Federico Capuana, A. Phinikaridou, R. Stefania, S. Padovan, Begoña Lavin, S. Lacerda, Eyad Almouazen, Y. Chevalier, Laurence Heinrich-Balard, R. Botnar, S. Aime, G. Digilio   +11 more
semanticscholar   +1 more source

Decreased expression of cytokeratin 15 and tropoelastin in men with androgenetic alopecia and its relationship with increased expression of p15/p16

Archives of Medical Science, 2020
Introduction Androgenetic alopecia (AGA) or male pattern baldness is a polygenic disease with a high prevalence in the Caucasian population, with psychosocial implications. However, the molecular mechanisms involved are unknown. The aim of this study was
Miguel A. Ortega, María J. Álvarez-Rocha, Ángel Asúnsolo, Beatriz Romero, Santiago Coca, Melchor Álvarez-Mon, Julia Buján, Natalio García-Honduvilla   +7 more
doaj   +1 more source

Autosomal Recessive Cutis Laxa 1C Mutations Disrupt the Structure and Interactions of Latent TGFβ Binding Protein-4

Frontiers in Genetics, 2021
Latent TGFβ binding protein-4 (LTBP4) is a multi-domain glycoprotein, essential for regulating the extracellular bioavailability of TGFβ and assembly of elastic fibre proteins, fibrillin-1 and tropoelastin.
Yasmene F. Alanazi, Michael P. Lockhart-Cairns, Stuart A. Cain, Thomas A. Jowitt, Anthony S. Weiss, Anthony S. Weiss, Anthony S. Weiss, Clair Baldock   +7 more
doaj   +1 more source

Incorporation of Human Recombinant Tropoelastin into Silk Fibroin Membranes with the View to Repairing Bruch’s Membrane

Journal of Functional Biomaterials, 2015
Bombyx mori silk fibroin membranes provide a potential delivery vehicle for both cells and extracellular matrix (ECM) components into diseased or injured tissues. We have previously demonstrated the feasibility of growing retinal pigment epithelial cells
Audra M. A. Shadforth, Shuko Suzuki, Raphaelle Alzonne, Grant A. Edwards, Neil A. Richardson, Traian V. Chirila, Damien G. Harkin   +6 more
doaj   +1 more source

Multifunctional SilkTropoelastin Biomaterial Systems [PDF]

Israel Journal of Chemistry, 2013
AbstractNew multifunctional, degradable, polymeric biomaterial systems would provide versatile platforms to address cell and tissue needs in both in vitro and in vivo environments. While protein‐based composites or alloys are the building blocks of biological organisms, similar systems have not been largely exploited, to date, to generate ad hoc ...
Chiara E, Ghezzi, Jelena, Rnjak-Kovacina, Anthony S, Weiss, David L, Kaplan   +3 more
openaire   +2 more sources

Transforming Growth Factor β1 and Tropoelastin Expression in Uterine Prolapse

Indonesian Journal of Obstetrics and Gynecology, 2016
Objective: To know the correlation of the expression of transforming growth factor beta (TGF-β1) and tropoelastin in uterine prolapse. Method: A cross-sectional study of 30 subjects suffered from uterine prolapse in the Department of Obstetrics and ...
Alvilusia Alvilusia, Amir Fauzi, Azhari Azhari, Wresnindyatsih Wresnindyatsih, Irsan Saleh   +4 more
doaj   +1 more source

Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. [PDF]

, 2017
Aims: Mast cells are versatile innate immune cells and are reported to promote vascular inflammation and neointimal lesion formation, thereby contributing to the development of vascular stenosis and atherosclerosis.
Kennedy, Simon, Lawrence, Catherine E., Wadsworth, Roger M., Wu, Junxi   +3 more
core   +8 more sources

Targeted disruption of fibulin-4 abolishes elastogenesis and causes perinatal lethality in mice [PDF]

, 2006
Elastic fibers provide tissues with elasticity which is critical to the function of arteries, lungs, skin, and other dynamic organs. Loss of elasticity is a major contributing factor in aging and diseases.
Broekelmann, Thomas J, Chen, Qiuyun, Horiguchi, Masahito, Marmorstein, Alan D, Marmorstein, Lihua Y, McKay, Brian, McLaughlin, Precious J, Mecham, Robert, Nakamura, Tomoyuki, Stanton, J. Brett, Starcher, Barry C   +10 more
core   +3 more sources

Conformational and thermal characterization of a synthetic peptidic fragment inspired from human tropoelastin: Signature of the amyloid fibers [PDF]

, 2014
Objectives : This work deals with the conformational and thermal characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin by the matrix metalloproteinase-12 that was shown to form amyloid-like fibres under ...
Bochicchio, Brigida, Dandurand, Jany, Lacabanne, Colette, Lacoste-Ferré, Marie-Hélène, Pepe, Antonietta, Samouillan, Valérie   +5 more
core   +4 more sources

Elastic fiber assembly is disrupted by excessive accumulation of chondroitin sulfate in the human dermal fibrotic disease, keloid [PDF]

, 2009
Keloid is a fibrotic disease characterized by abnormal accumulation of extracellular matrix in the dermis. The keloid matrix contains excess collagen and glycosaminoglycans (GAGs), but lacks elastic fiber. However, the roles of these matrix components in
Ikeda, Mika, Ishiko, Toshihiro, Kubota, Hiroshi, Kurokawa, Masako, Nagata, Kazuhiro, Naitoh, Motoko, Nakamura, Tomiyuki, Suzuki, Shigehiko, Utani, Atsushi, Yamawaki, Satoko, Yoshikawa, Katsuhiro   +10 more
core   +1 more source