Electrospun ECM macromolecules as biomimetic scaffold for regenerative medicine: challenges for preserving conformation and bioactivity [PDF]
, 2017 The extracellular matrix (ECM), the physiological scaffold for cells in vivo, provides structural support to cells and guaranties tissue integrity. At the same time, however, it represents an extremely complex and finely tuned signaling environment that ...
CAMPIGLIO, CHIARA EMMA +2 more
core +2 more sources
Searching low-energy conformations of two elastin sequences
, 2004 The three-dimensional structures of two common repeat motifs Val$^1$-Pro$^2$-Gly$^3$-Val$^4$-Gly$^5$ and Val$^1$-Gly$^2$-Val$^3$-Pro$^4$-Gly$^5$-Val$^6$-Gly$^7$-Val$^8$-Pro$^9$ of tropoelastin are investigated by using the multicanonical simulation ...
Arkin, H.
core +1 more source
Conformational and thermal characterization of a synthetic peptidic fragment inspired from human tropoelastin: Signature of the amyloid fibers [PDF]
, 2014 Objectives : This work deals with the conformational and thermal characterization of a synthetic peptide (S4) released during the proteolysis of human tropoelastin by the matrix metalloproteinase-12 that was shown to form amyloid-like fibres under ...
Bochicchio, Brigida +5 more
core +3 more sources
Coacervation Characteristics of Recombinant Human Tropoelastin [PDF]
European Journal of Biochemistry, 1997 Coacervation of soluble tropoelastin molecules is characterized by thermodynamically reversible association as temperature is increased under appropriately juxtaposed ionic conditions, protein concentration and pH. Coacervation plays a critical role in the assembly of these elastin precursors in elastic fiber formation.
Sacha A. Jensen +2 more
openaire +3 more sources
Plasma ion implantation enabled bio-functionalization of PEEK improves osteoblastic activity
APL Bioengineering, 2018 Slow appositional growth of bone in vivo is a major problem associated with polyether ether ketone (PEEK) based orthopaedic implants. Early stage promotion of osteoblast activity, particularly bone nodule formation, would help to improve contact between ...
Edgar A. Wakelin +4 more
doaj +1 more source
Molecular assembly and mechanical properties of the extracellular matrix: A fibrous protein perspective [PDF]
, 2013 The extracellular matrix is an integral and dynamic component of all tissues. Macromolecular compositions and structural architectures of the matrix are tissue-specific and typically are strongly influenced by the magnitude and direction of biomechanical
Keeley, Fred W., Muiznieks, Lisa D.
core +1 more source
Extracellular Matrix Molecules Facilitating Vascular Biointegration
Journal of Functional Biomaterials, 2012 All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy.
Martin K.C. Ng +3 more
doaj +1 more source
Characterization of Endothelial Progenitor Cell Interactions with Human Tropoelastin. [PDF]
PLoS ONE, 2015 The deployment of endovascular implants such as stents in the treatment of cardiovascular disease damages the vascular endothelium, increasing the risk of thrombosis and promoting neointimal hyperplasia.
Young Yu +13 more
doaj +1 more source
Elastin-like Polypeptides in Development of Nanomaterials for Application in the Medical Field
Frontiers in Nanotechnology, 2022 Elastin-like polypeptides (ELPs) are biopolymers formed by amino acid sequences derived from tropoelastin. These biomolecules can be soluble below critical temperatures, forming aggregates at higher temperatures, which makes them an interesting source ...
Letícia Ferreira Lima +19 more
doaj +1 more source
Extracellular Matrix Molecules Facilitating Vascular Biointegration [PDF]
, 2014 All vascular implants, including stents, heart valves and graft materials exhibit suboptimal biocompatibility that significantly reduces their clinical efficacy.
Michael, Praveesuda +3 more
core +1 more source