The changes in chemical composition during development of the bovine nuchal ligament [PDF]
, 1967 Whole bovine nuchal ligaments, or portions thereof (in the case of commercially valuable animals), were obtained from 45 animals (28 fetal and 17 postnatal) ranging in age from 110 days of gestation to 10 yr. Insoluble elastin was quantitatively prepared
Cleary, E. G. +2 more
core +3 more sources
Physiological Reports, 2020 Pelvic organ prolapse (POP) decreases quality of life for many women, but its pathophysiology is poorly understood. We have previously shown that Lysyl oxidase‐like 1 knockout (Loxl1 KO) mice reliably prolapse with age and increased parity, similar to ...
Slater A. Jameson +8 more
doaj +1 more source
Elastogenic protein expression of a highly elastic murine spinal ligament: the ligamentum flavum. [PDF]
PLoS ONE, 2012 Spinal ligaments, such as the ligamentum flavum (LF), are prone to degeneration and iatrogenic injury that can lead to back pain and nerve dysfunction. Repair and regeneration strategies for these tissues are lacking, perhaps due to limited understanding
Jeffrey P Brown +3 more
doaj +1 more source
Elastin is Localised to the Interfascicular Matrix of Energy Storing Tendons and Becomes Increasingly Disorganised With Ageing [PDF]
, 2017 Tendon is composed of fascicles bound together by the interfascicular matrix (IFM). Energy storing tendons are more elastic and extensible than positional tendons; behaviour provided by specialisation of the IFM to enable repeated interfascicular sliding
A Heinz +48 more
core +4 more sources
Coacervation Characteristics of Recombinant Human Tropoelastin [PDF]
European Journal of Biochemistry, 1997 Coacervation of soluble tropoelastin molecules is characterized by thermodynamically reversible association as temperature is increased under appropriately juxtaposed ionic conditions, protein concentration and pH. Coacervation plays a critical role in the assembly of these elastin precursors in elastic fiber formation.
B, Vrhovski, S, Jensen, A S, Weiss
openaire +2 more sources
Electrospun ECM macromolecules as biomimetic scaffold for regenerative medicine: challenges for preserving conformation and bioactivity [PDF]
, 2017 The extracellular matrix (ECM), the physiological scaffold for cells in vivo, provides structural support to cells and guaranties tissue integrity. At the same time, however, it represents an extremely complex and finely tuned signaling environment that ...
CAMPIGLIO, CHIARA EMMA +2 more
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Journal of Lipid Research, 1998 Although a morphologically distinct population of lipid-laden interstitial cells (lipofibroblasts, LF), has been identified, the origins and functions of this population during lung development and disease remain undefined.
Heshun Chen +3 more
doaj +1 more source
Characterization of Microfibrillar-associated Protein 4 (MFAP4) as a Tropoelastin- and Fibrillin-binding Protein Involved in Elastic Fiber Formation [PDF]
, 2015 MFAP4 (microfibrillar-associated protein 4) is an extracellular glycoprotein found in elastic fibers without a clearly defined role in elastic fiber assembly.
Heumüller, Stefanie E +11 more
core +1 more source
Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries [PDF]
, 2017 Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial ...
Broekelmann, Thomas J +5 more
core +3 more sources
Plasma ion implantation enabled bio-functionalization of PEEK improves osteoblastic activity
APL Bioengineering, 2018 Slow appositional growth of bone in vivo is a major problem associated with polyether ether ketone (PEEK) based orthopaedic implants. Early stage promotion of osteoblast activity, particularly bone nodule formation, would help to improve contact between ...
Edgar A. Wakelin +4 more
doaj +1 more source