Results 211 to 220 of about 4,124 (226)

N-tropomodulin: A novel isoform of tropomodulin identified as the major binding protein to brain tropomyosin

Journal of Cell Science, 1996
ABSTRACT We have identified and characterized two proteins in rat brain that bind to the neuron-specific tropomyosin isoform, TMBr3. The two proteins were identified by blot overlay assay, in which the proteins immobilized on the membrane were probed by epitope-tagged TMBr3, followed by detection with anti-epitope antibody.
Watakabe, A Watakabe, Akiya, Kobayashi, R Kobayashi, Ryuji, Helfman, DM Helfman, David M   +2 more
openaire   +2 more sources

Tropomodulin‐1—From the actin slow‐growing end to multifunctional roles

FEBS Letters
Tropomodulin‐1 (TMOD1) is a key regulator of actin filament dynamics that functions as an actin‐binding protein. It specifically caps the slow‐growing (pointed) ends of actin filaments, and the interaction is further stabilized by tropomyosin (TPM).
Yalong Li, Xuyi Pan, Zixuan Gong, Lin Zhu, Ping Mu, F. Lu   +5 more
semanticscholar   +1 more source

Tropomodulin

1999
Abstract Tropomodulin (Tmod) is a ∼40 kDa tropomyosin- and actin-binding protein that is associated with the slow growing (pointed) ends of stable, tropomyosin-coated actin filaments in muscle and non-muscle cells. In vitro and in vivo data indicate that Tmod functions to cap the pointed ends of tropomyosin-actin filaments and prevent ...
Velia M Fowler, Catharine A Conley
openaire   +1 more source

Induced expression of the transcription of tropomodulin 1 by Wnt5a and characterization of the tropomodulin 1 promoter

Biochemical and Biophysical Research Communications, 2007
Microarray analysis was carried out to identify novel downstream target genes regulated by non-canonical Wnt signaling. We found that Tmod1, known as an actin-capping protein, is up-regulated by Wnt5a, while gelsolin, known as an actin-severing protein, is down-regulated by Wnt5a.
Sangmoon, Yun, Yeonmi, Rim, Eek-hoon, Jho   +2 more
openaire   +2 more sources

Tropomodulin 3 Overexpression as a Marker for Platinum Resistance and Immune Infiltration in Ovarian Cancer.

Journal of Visualized Experiments
The cytoskeleton plays an important role in platinum resistance in ovarian cancer. Tropomodulin 3 (TMOD3) is critical in the development of many tumors, but its role in the drug resistance of ovarian cancer remains unexplored.
Dingwen Xu, Xiaofei Hu, Yang Feng, Zhihua Lu, Xianmei Liu, Huishen Yan, Jianming Peng, Sen Luo, Weijuan Yao   +8 more
semanticscholar   +1 more source

Chicken skeletal muscle tropomodulin: novel localization and characterization

Cell and Tissue Research, 1996
Tropomodulin is a 40.6-kDa isoform-specific tropomyosin-binding protein which inhibits actin filament elongation from the slow-growing (pointed) end and localizes at or near the pointed ends of thin filaments in rat skeletal muscle. Immunofluorescent localization using affinity-purified anti-tropomodulin antibodies in avian myofibril preparations ...
M A, Sussman, M, Ito, M P, Daniels, B, Flucher, S, Buranen, L, Kedes   +5 more
openaire   +2 more sources

Neural tropomodulin: developmental expression and effect of seizure activity

Developmental Brain Research, 1994
Tropomodulin is a 40.6 kDa tropomyosin-binding protein associated with actin filaments in muscle and the membrane cytoskeleton in erythrocytes. We have detected tropomodulin mRNA and protein in brains of rats by northern and western blot analyses.
M A, Sussman, S, Sakhi, G, Tocco, I, Najm, M, Baudry, L, Kedes, S S, Schreiber   +6 more
openaire   +2 more sources

Tropomodulin function and thin filament assembly in cardiac myocytes

Trends in Cardiovascular Medicine, 1996
The regulation of thin filament length is a fundamental property of all striated muscles. Tropomodulin is an actin and tropomyosin binding protein that is exclusively associated with the free (pointed) ends of thin filaments. In vitro and in vivo studies reveal that tropomodulin is an actin filament pointed end capping protein, which is required to ...
C C, Gregorio, V M, Fowler
openaire   +2 more sources

Making tropomodulin find the right point

Science, 2014
Actin Cytoskeleton Actin filaments are a key component of the cell's cytoskeleton. Actin filaments have a characteristic polarized architecture with a so-called barbed end and a pointed end—so described because of how the filaments look under the electron microscope when they are coated ...
openaire   +1 more source

Tropomodulin: An Important Player in Cardiac Myofibrillogenesis

2002
Tropomodulin has been studied intensively since it was first reported in 1987 as a tropomyosin binding protein associated with the erythrocyte membrane skeleton (Fowler, 1987). The study of tropomodulin’s role in heart myofibrillogenesis was initiated after the discovery that in mature skeletal muscle tropomodulin was localized to the pointed (slow ...
Catherine McLellan, Carol C. Gregorio
openaire   +1 more source