Results 91 to 100 of about 59,695 (281)
Aging Cell, EarlyView.Transcriptomic and cellular analyses of BubR1 hypomorphic hearts reveal disruptions in key pathways and upregulation of markers linked to impaired cardiac structure and function. Comparative transcriptomic analysis shows that BubR1 insufficiency mirrors changes seen in aged and failing hearts. A key finding of this study is that BubR1 levels decline in
Renju Pun +13 more
wiley +1 more source
Crosslinking of tropomyosin to myosin subfragment-1 in reconstituted rabbit skeletal thin filaments [PDF]
, 1984 Rabbit skeletal tropomyosin was labeled with the bifunctional photoactivatable crosslinker N-succinimidyl-6-(4′-azido-2′-nitrophenylamino)hexanoate. After irradiating the rigor complex composed of myosin subfragment-1, crosslinker-labeled tropomyosin ...
Lamkin, Mark, Tao, Terence
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Innovative pharmacotherapy for hepatic metabolic and chronic inflammatory diseases in China
British Journal of Pharmacology, EarlyView.Abstract Liver disease constitutes a significant global health concern, particularly in China where it has distinctive characteristics. China grapples with a staggering 300 million cases, predominantly due to hepatitis B and metabolic non‐alcoholic fatty liver disease. Additionally, hepatocellular carcinoma has become a prevalent which is a lethal type
Feng Zhang +5 more
wiley +1 more source
Biomolecules, 2020 Cardiovascular diseases are one of the leading causes of death in developing countries, generally originating as coronary artery disease (CAD) or hypertension. In later stages, many CAD patients develop left ventricle dysfunction (LVD).
Surendra Kumar +2 more
doaj +1 more source
Repression of the Glucocorticoid Receptor Aggravates Acute Ischemic Brain Injuries in Adult Mice. [PDF]
, 2018 Strokes are one of the leading causes of mortality and chronic morbidity in the world, yet with only limited successful interventions available at present.
Concepcion, Katherine R +8 more
core +2 more sources
Psilocybin as a novel treatment for chronic pain
British Journal of Pharmacology, EarlyView.Abstract Psychedelic drugs are under active consideration for clinical use and have generated significant interest for their potential as anti‐nociceptive treatments for chronic pain, and for addressing conditions like depression, frequently co‐morbid with pain.
Tate Askey +3 more
wiley +1 more source
A comparison of the distribution of actin and tubulin in the mammalian mitotic spindle as seen by indirect immunofluorescence [PDF]
, 1977 Rabbit antibodies against actin and tubulin were used in an indirect immunofluorescence study of the structure of the mitotic spindle of PtK1 cells after lysis under conditions that preserve anaphase chromosome movement. During early prophase there is no
Cande, W. Zacheus +2 more
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Early Origins of Asthma and Allergies: Clues From Studies in China
Clinical &Experimental Allergy, EarlyView.The environment we live in harbours both risk and protective factors for asthma and allergies. This is particularly relevant in China, where unique environmental and cultural factors shape disease development. The interplay between these environmental factors, airway immunity, and gut microbiome shapes the susceptibility to asthma and allergies ...
Yike Wang +5 more
wiley +1 more source
Food Science and Human WellnessIn recent years, the allergy rate of oysters has surged, and daily food processing methods make it hard to reduce heat resistance and digestive allergy such as tropomyosin (TM).
Chenchen Yu +9 more
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Food and Agricultural Immunology, 2019 Transglutaminase (TG) is a major food processing enzyme that induces protein cross-linking. Tropomyosin (TM) is a major shellfish allergen that is responsible for at least 80% of the shrimp allergic incidents.
Linglin Fu +3 more
doaj +1 more source