Results 31 to 40 of about 206,412 (354)

Exosomes and their roles in the chemoresistance of pancreatic cancer

Cancer Medicine, Volume 11, Issue 24, Page 4979-4988, December 2022., 2022
Despite the development of multiple promising chemotherapeutic agents as recommended first‐line treatment for PC, the therapeutic efficacy is largely limited by unwanted drug resistance.Exploring the relation between exosomes and chemoresistance may be conducive to understanding molecular mechanisms and taking effective measures to reduce the ...
Yubin Pan, Honglin Tang, Qijun Li, Guangpeng Chen, Da Li   +4 more
wiley   +1 more source

Investigating the role of uncoupling of troponin I phosphorylation from changes in myofibrillar Ca(2+)-sensitivity in the pathogenesis of cardiomyopathy. [PDF]

, 2014
Contraction in the mammalian heart is controlled by the intracellular Ca2+ concentration as it is in all striated muscle, but the heart has an additional signalling system that comes into play to increase heart rate and cardiac output during exercise or ...
Marston, SB, Messer, AE
core   +2 more sources

High‐Sensitivity Troponin I Levels and Coronary Artery Disease Severity, Progression, and Long‐Term Outcomes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2018
BackgroundThe associations between high‐sensitivity troponin I (hsTnI) levels and coronary artery disease (CAD) severity and progression remain unclear.
Ayman Samman Tahhan, Pratik Sandesara, Salim S. Hayek, Muhammad Hammadah, Ayman Alkhoder, Heval M. Kelli, Matthew Topel, Wesley T. O'Neal, Nima Ghasemzadeh, Yi‐An Ko, Mohamad Mazen Gafeer, Naser Abdelhadi, Fahad Choudhary, Keyur Patel, Agim Beshiri, Gillian Murtagh, Jonathan Kim, Peter Wilson, Leslee Shaw, Viola Vaccarino, Stephen E. Epstein, Laurence Sperling, Arshed A. Quyyumi   +22 more
doaj   +1 more source

High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis [PDF]

, 2014
Aims: High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis.
A. L. Hunter, A. Maria Choy, A. S. V. Shah, C. C. Lang, C. W. L. Chin, Cowell, D. A. McAllister, D. E. Newby, Dweck, Dweck, F. E. Strachan, J. P. Langrish, M. R. Dweck, Messroghli, Mills, N. A. Boon, N. L. Mills, Nkomo, Rosjo, S. Alam, S. Joanna Cowell, S. Walker, Thygesen, Wieczorek   +23 more
core   +4 more sources

Randomized Trial of the Effects of Insulin and Metformin on Myocardial Injury and Stress in Diabetes Mellitus: A Post Hoc Exploratory Analysis

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundSubclinical myocardial injury, as measured by high‐sensitivity cardiac troponin T (hsTnT), and myocardial stress, as measured by N‐terminal pro‐B‐type natriuretic peptide (NT‐proBNP), are related to glycemic control in patients with type 2 ...
Pratyaksh K. Srivastava, Aruna D. Pradhan, Nancy R. Cook, Paul M Ridker, Brendan M. Everett   +4 more
doaj   +1 more source

Which diagnostic tests are most useful in a chest pain unit protocol? [PDF]

, 2005
Background The chest pain unit (CPU) provides rapid diagnostic assessment for patients with acute, undifferentiated chest pain, using a combination of electrocardiographic (ECG) recording, biochemical markers and provocative cardiac testing.
Angelini, K., Arnold, J., Goodacre, S., Locker, T., Morris, F.   +4 more
core   +3 more sources

The implementation of persuasive technology principles in mobile application development: a qualitative study [PDF]

, 2012
Preceding studies of persuasive technology have mentioned several benefits on the implementation of persuasive design features of the Persuasive System Design (PSD) model such as creating users' engagement and acceptance and continuous usage.
Abd Rahim, Mohd Hilmi Izwan, Goh, Kai Chen, Masrom, Md Asrul Nasid, Mohamed, Sulzakimin, Yunus, Riduan   +4 more
core   +3 more sources

Prognostic Value of New‐Generation Troponins in ST‐Segment–Elevation Myocardial Infarction in the Modern Era: The RUTI‐STEMI Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundIn ST‐segment–elevation myocardial infarction (STEMI), troponins are not needed for diagnosis: symptoms and ECG data are sufficient to activate percutaneous coronary intervention.
Germán Cediel, Ferran Rueda, Cosme García, Teresa Oliveras, Carlos Labata, Jordi Serra, Julio Núñez, Vicent Bodí, Marc Ferrer, Josep Lupón, Antoni Bayes‐Genis   +10 more
doaj   +1 more source

The 99th percentile of reference population for cTnI and cTnT assay: Methodology, pathophysiology and clinical implications [PDF]

, 2017
According to recent international guidelines, including the 2012 Third Universal Definiton of Myocardial Infarction by the Joint ESC/ACCF/AHA/WHF Task Force, an increase in cardiac troponin (cTn) levels over the 99th percentile upper reference limit ...
Clerico, Aldo, Masotti, Silvia, Passino, Claudio, Plebani, Mario, Prontera, Concetta, Ripoli, Andrea, Zaninotto, Martina   +6 more
core   +1 more source

Predictive value of serum initial brain natriuretic peptide and troponin on functional prognosis in noncardiogenic patients with anterior and posterior circulation cerebral infarction

Arquivos de Neuro-Psiquiatria, 2022
Background Brain natriuretic peptide (BNP) and troponin have a close relationship with cardiogenic cerebral embolism (CCE), but their relationship with noncardiogenic patients with anterior circulation ischemia (ACI) and posterior circulation ischemia ...
Wan-Ting Lu, Wen-Ting Du, De-Sheng Lu, Jie You, Hong-yan Li   +4 more
doaj   +1 more source