Results 61 to 70 of about 230,788 (365)

Tapered Pillar Design for High‐Precision Force Readout in Miniaturized Engineered Heart Tissues From Human Pluripotent Stem Cells

Advanced Healthcare Materials, EarlyView.
Engineered heart tissues (EHTs) are a valuable approach in capturing human cardiac physiology and drug responses in vitro. Here, a novel tapered pillar design is developed in an EHT platform to confine tissues in a predefined position‐ at the middle of the pillar height.
Milica Dostanić, Maury Wiendels, Laura M. Windt, Mervyn P.H. Mol, Francijna E. van den Hil, Richard P. Davis, Valeria Orlova, Berend J. van Meer, Massimo Mastrangeli, Christine L. Mummery   +9 more
wiley   +1 more source

Relationship Between Peak Troponin Values and Long‐Term Ischemic Events Among Medically Managed Patients With Acute Coronary Syndromes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundThe relationship between troponin level and outcomes among patients with non‐ST‐segment elevation ACS is established, but the relationship of troponin level with long‐term outcomes among medically managed non‐ST‐segment elevation ACS patients ...
Sarah A. Goldstein, L. Kristin Newby, Derek D. Cyr, Megan Neely, Thomas F. Lüscher, Eileen B. Brown, Harvey D. White, E. Magnus Ohman, Matthew T. Roe, Christian W. Hamm   +9 more
doaj   +1 more source

Aberrant Expression of Cardiac Troponin-T in Lung Cancer Tissues in Association With Pathological Severity

Frontiers in Cardiovascular Medicine, 2022
BackgroundCardiac troponin-T (TNNT2) is exclusively present in cardiac muscle. Measurement of TNNT2 is used for diagnosing acute coronary syndrome. However, its expression may not be limited in myocardium. This study aimed at evaluating the expression of
Toshihiro Tsuruda, Yuichiro Sato, Masaki Tomita, Hiroyuki Tanaka, Kinta Hatakeyama, Misa Otsu, Aya Kawano, Keiko Nagatomo, Naoki Yoshikawa, Ryuji Ikeda, Yujiro Asada, Koichi Kaikita   +11 more
doaj   +1 more source

Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study. [PDF]

, 2012
Troponin C (TnC) is an important regulatory molecule in cardiomyocytes. Calcium binding to site II in TnC initiates a series of molecular events that result in muscle contraction.
Huber, Gary, Kekenes-Huskey, Peter M, Lindert, Steffen, McCammon, J Andrew, Pierce, Levi   +4 more
core   +2 more sources

Robust pH Sensing Using a Graphene Oxide and Covalent Organic Frameworks Composite for Gastro‐esophageal Reflux Disease Diagnosis

Advanced Healthcare Materials, EarlyView.
A stable composite pH sensor is developed by coating graphene oxide (GO) nanosheets with covalent organic frameworks (COFs) to improve stability and sensitivity in acidic environments. The GO/COFs sensor demonstrates high selectivity, linearity, and biocompatibility, offering a promising strategy for continuous pH monitoring in gastro‐esophageal reflux
Ahmed H. M. Salem, Jianhui Zhang, Ashley Lam, Haowei Wang, Umber Cheema, Laurence B. Lovat, Manish K. Tiwari   +6 more
wiley   +1 more source

Evidence and Cost Effectiveness Requirements for Recommending New Biomarkers. [PDF]

, 2015
B-type natriuretic peptide (BNP) and NT-proBNP are widely used plasma biomarkers for the diagnosis of acute decompensated heart failure and prognosis for future cardiac disease.
Collinson, P
core   +4 more sources

Neurohormonal Blockade and Circulating Cardiovascular Biomarkers During Anthracycline Therapy in Breast Cancer Patients: Results From the PRADA (Prevention of Cardiac Dysfunction During Adjuvant Breast Cancer Therapy) Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundAnthracyclines are associated with cardiotoxic effects. Cardiovascular biomarkers may reflect myocardial injury, dysfunction, inflammation, and fibrosis and may precede and predict the development of left ventricular impairment. The aim of this
Geeta Gulati, Siri L. Heck, Helge Røsjø, Anne H. Ree, Pavel Hoffmann, Tor‐Arne Hagve, Jon Norseth, Berit Gravdehaug, Kjetil Steine, Jürgen Geisler, Torbjørn Omland   +10 more
doaj   +1 more source

Biosensors for cardiac biomarkers detection: a review [PDF]

, 2012
The cardiovascular disease (CVD) is considered as a major threat to global health. Therefore, there is a growing demand for a range of portable, rapid and low cost biosensing devices for the detection of CVD.
Gurbuz, Yasar, Gürbüz, Yaşar, Kolkar Mohammed, Javed Hussain Niazi, Qureshi, Anjum   +3 more
core   +1 more source

Measurement of cardiac troponins [PDF]

Annals of Clinical Biochemistry, 2001
The cardiac troponins form part of the regulatory mechanism for muscle contraction. Specific cardiac isoforms of cardiac troponin T and cardiac troponin I exist and commercially available immunoassay systems have been developed for their measurement. A large number of clinical and analytical studies have been performed and the measurement of cardiac ...
David Gaze, Frances Boa, Paul O. Collinson   +2 more
openaire   +3 more sources

Body Biofluids for Minimally‐Invasive Diagnostics: Insights, Challenges, Emerging Technologies, and Clinical Potential

Advanced Healthcare Materials, EarlyView.
Recent advances in diagnostics have accelerated the development of miniaturized wearable technologies for the continuous monitoring of diseases. This paradigm is shifting healthcare away from invasive, centralized blood tests toward decentralized monitoring, using alternative body biofluids.
Lanka Tata Rao, Chandan Kumar Mandal, Fernando Patolsky   +2 more
wiley   +1 more source