Results 71 to 80 of about 206,412 (354)

Home‐Based Tele‐tDCS in Amyotrophic Lateral Sclerosis: Feasibility, Safety, and Preliminary Efficacy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with limited treatment options. Transcranial direct current stimulation (tDCS) shows promise as a neuromodulatory intervention in various neurological disorders, but its application in ALS, particularly in a remote, home‐based format, remains underexplored.
Sangeetha Madhavan, Shravni Deshmukh, Mark Cummings, Aditi Doshi, Kourosh Rezania, Sally Freels, Gina Sawa   +6 more
wiley   +1 more source

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Liver parameters as part of a non-invasive model for prediction of all-cause mortality after myocardial infarction

Archives of Medical Science, 2019
Introduction Liver parameters are associated with cardiovascular disease risk and severity of stenosis. It is unclear whether liver parameters could predict the long-term outcome of patients after acute myocardial infarction (AMI).
Theodor Baars, Jan-Peter Sowa, Ursula Neumann, Stefanie Hendricks, Mona Jinawy, Julia Kälsch, Guido Gerken, Tienush Rassaf, Dominik Heider, Ali Canbay   +9 more
doaj   +1 more source

TRoponin of Unknown origin in STroke evaluated by multi-component cardiac Magnetic resonance Imaging – The TRUST-MI study

Frontiers in Cardiovascular Medicine, 2022
AimsIncreased high-sensitive cardiac troponin I (hs-cTnI) levels are common in patients with acute ischemic stroke. However, only a minority demonstrates culprit lesions on coronary angiography, suggesting other mechanisms, e.g., inflammation, as ...
Annerose Mengel, Lilyana Nenova, Karin A. L. Müller, Sven Poli, Markus C. Kowarik, Markus C. Kowarik, Katharina Feil, Lars Mizera, Tobias Geisler, Jens Kübler, Heiko Mahrholdt, Ulrike Ernemann, Florian Hennersdorf, Ulf Ziemann, Konstantin Nikolaou, Meinrad Gawaz, Patrick Krumm, Simon Greulich   +17 more
doaj   +1 more source

High sensitivity troponins and conventional troponins at the bedside

International Journal of Critical Illness and Injury Science, 2014
The continuing advances in the biochemical research for the discovering an ideal biomarker for diagnosing myocardial injury have led to discovery cardiac Troponin, a biochemical gold standard for myocardial necrosis. Further with advances in the immunoassay techniques, the 99th percentile cutoff value of cardiac troponin required for the diagnosis of ...
Sanjeev Bhoi, Pankaj Verma, Sameer Vankar, Sagar Galwankar   +3 more
openaire   +3 more sources

Physical limits on computation by assemblies of allosteric proteins [PDF]

, 2008
Assemblies of allosteric proteins, nano-scale Brownian computers, are the principle information processing devices in biology. The troponin C-troponin I (TnC-TnI) complex, the Ca$^{2+}$-sensitive regulatory switch of the heart, is a paradigm for Brownian computation.
arxiv   +1 more source

Biologically‐Inspired Melt Electrowriting for the Generation of Highly Biomimetic Functional Myocardium

Advanced Functional Materials, EarlyView.
In this work, melt electrowriting is used to fabricate a 3D printed scaffold design that generates engineered cardiac tissues with in‐plane contraction, mimicking natural myocardium. It is shown that these tissues display advanced maturation and functionality.
Olalla Iglesias‐García, María Flandes‐Iparraguirre, Pilar Montero‐Calle, Ricardo M. Rosales, Asier Ullate‐Agote, Andrea Sánchez‐Bueno, Eduardo Larequi, Ilazki Anaut‐Lusar, Nicolás Laita, Aida Oliván‐Viguera, Elena Iglesias, Gloria Abizanda, Patxi San Martín‐Úriz, Paula Aguirre‐Ruiz, Xabier L. Aranguren, Manuel García de Yébenes, Juan José Gavira, Miguel Ángel Martínez, Estefanía Peña, Manuel Doblaré, Elena M. de‐Juan‐Pardo, Esther Pueyo, Felipe Prosper, Manuel M. Mazo Vega   +23 more
wiley   +1 more source

Proximity mapping of troponin T and troponin I in cardiac troponin using molecular dynamics simulations [PDF]

Biophysical Journal, 2009
The intersite distances from cTnT residues 240, 276, and 288 to cTnI N-terminal residues 5, 17, 27, 40, and to the cTnI C-terminal residues 131, 145, 152, 160, and 167 in reconstituted cTn were determined in the presence of Mg2+ and Mg2+ plus Ca2+ using FRET.
Wen-Ji Dong, Herbert C. Cheung, John M. Robinson, Jun Xing, Jayant James Jayasundar   +4 more
openaire   +2 more sources

Deep learning-enhanced chemiluminescence vertical flow assay for high-sensitivity cardiac troponin I testing [PDF]

Small (2025)
Democratizing biomarker testing at the point-of-care requires innovations that match laboratory-grade sensitivity and precision in an accessible format. Here, we demonstrate high-sensitivity detection of cardiac troponin I (cTnI) through innovations in chemiluminescence-based sensing, imaging, and deep learning-driven analysis.
arxiv   +1 more source

Advanced Materials for Biological Field‐Effect Transistors (Bio‐FETs) in Precision Healthcare and Biosensing

Advanced Healthcare Materials, EarlyView.
This review explores how advanced materials enhance Bio‐FETs for precision healthcare and biosensing. It covers their working principles, surface functionalization, and ultra‐sensitive detection capabilities. The integration of flexible designs, AI, and IoT for real‐time monitoring is discussed, along with challenges like material reproducibility and ...
Minal Pandey, Manish Bhaiyya, Prakash Rewatkar, Jitendra B. Zalke, Nitin P. Narkhede, Hossam Haick   +5 more
wiley   +1 more source