Results 111 to 120 of about 19,854,960 (401)

Plant proteases and anti-bacterial substances in Allium sativum L. varieties

Foods and Raw Materials
Allium sativum L. protease still remains largely understudied although new varieties of garlic appear quite often, e.g., lanang garlic. This study tested the antibacterial effect of garlic and the effectiveness of various A.
Budianto Budianto, Muh Jaenal Arifin, Naryani Naryani, Endah Sukmawati, Suwaji Suwaji, Tri Handoko Moedji Wibowo, Syahilla Vanda Luviana, Lia Dekryt Vergiana Putri   +7 more
doaj   +1 more source

Coarse-Grained Modeling of Peptide Docking Associated with Large Conformation Transitions of the Binding Protein: Troponin I Fragment–Troponin C System

Molecules, 2015
Most of the current docking procedures are focused on fine conformational adjustments of assembled complexes and fail to reproduce large-scale protein motion. In this paper, we test a new modeling approach developed to address this problem.
Jacek Wabik, Mateusz Kurcinski, Andrzej Kolinski   +2 more
doaj   +1 more source

Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C. [PDF]

Int J Mol Sci, 2023
Tikunova SB, Thuma J, Davis JP.
europepmc   +1 more source

DCM troponin C mutant Gly159Asp blunts the response to troponin phosphorylation

Biochemical and Biophysical Research Communications, 2007
Dilated cardiomyopathy (DCM) can be caused by a Gly159Asp mutation in cardiac troponin C (cTnC). Our previous work found that partial replacement of endogenous troponin in skinned muscle fibres with human cardiac troponin containing Gly159Asp cTnC had no significant effect on maximum force generation, Ca(2+)-sensitivity or cooperativity, but halved the
Preston, L, Ashley, C, Redwood, C
openaire   +4 more sources

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Association of Troponin, C-Reactive protein, Albumin and C-Reactive protein/Albumin Ratios with Mortality in Intensive Care Unit Patients with Community-acquired Pneumonia

Acta Medica Alanya
Aim: Parameters used to determine prognosis in community-acquired pneumonia (CAP) patients often have limited clinical value. This study aims to examine the efficacy of CRP, albumin, CRP/albumin ratio and troponin elevation in predicting 30-day mortality
Halil İbrahim Doru, Furkan Akpınar, Şenol Arslan, Nazım Onur Can   +3 more
doaj   +1 more source

YTnC2, an improved genetically encoded green calcium indicator based on toadfish troponin C. [PDF]

FEBS Open Bio, 2023
Subach OM, Vlaskina AV, Agapova YK, Nikolaeva AY, Varizhuk AM, Podgorny OV, Piatkevich KD, Patrushev MV, Boyko KM, Subach FV.   +9 more
europepmc   +1 more source

The combinational effect of cardiac and biochemical markers in diabetic patients with cardiovascular disease [PDF]

, 2011
Background: Clinicopathological correlations, as well as several angiographic studies, suggest that diabetic patients have more extensive atherosclerotic disease, affecting the coronary arteries in particular.
Palanisamy Pasupathi, YY Rao, Farook J, Sathiyamoorthy Subramaniyam, Babu Shankar Ponnusha, Athimoolam Ambika, Int J Cur Bio Med Sci.
core  

Tuning Cellular Perception in Pluripotent Stem Cells through Topography, Stiffness, and Patterning

Advanced NanoBiomed Research, EarlyView.
Micro‐ and nanotopographical cues, substrate stiffness, and mechanical patterning synergistically direct pluripotent stem cell fate and function by tuning cellular perception at the biointerface. Pluripotent stem cells (PSCs), comprised of embryonic stem cells and induced PSCs, hold tremendous therapeutic potential.
Yuan Jiang, Jann Harberts, Yaping Chen, Richard J. Williams, Wei Duan, Rasika M. Samarasinghe, Nicolas H. Voelcker, Roey Elnathan   +7 more
wiley   +1 more source

Steric blocking upside down: a different way of thinking about the competition between myosin and tropomyosin

Frontiers in Physics
At low free Ca2+, the actin binding proteins tropomyosin, troponin I, troponin T and troponin C inhibit contraction in striated muscles. Ca2+ activation alters the position of tropomyosin on actin to uncover binding sites for high affinity forms of ...
Joseph M. Chalovich
doaj   +1 more source