Results 121 to 130 of about 19,854,960 (401)

Computational Exploration and Characterization of Potential Calcium Sensitizing Mutations in Cardiac Troponin C. [PDF]

J Chem Inf Model, 2022
Hantz ER, Lindert S.
europepmc   +1 more source

Contemporary NSTEMI management: the role of the hospitalist. [PDF]

, 2019
Non-ST-segment elevation myocardial infarction (NSTEMI) is defined as elevated cardiac biomarkers of necrosis in the absence of persistent ST-segment elevation in the setting of anginal symptoms or other acute event.
Amin, Alpesh, Cohen, Marc, Deitelzweig, Steven, DiLascia, Christopher, Fanikos, John, Kaatz, Scott, Pollack, Charles V, Slattery, David, Tuder, Regan, Wang, Tracy   +9 more
core   +1 more source

Effects of Spaceflight on Human Induced Pluripotent Stem Cell-Derived Cardiomyocyte Structure and Function. [PDF]

, 2019
With extended stays aboard the International Space Station (ISS) becoming commonplace, there is a need to better understand the effects of microgravity on cardiac function. We utilized human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs)
Agrawal, Azakie, Baio, Becker, Bergmann, Burridge, Camberos, Connor, Drosatos, Fermini, Fritsch-Yelle, Garrett-Bakelman, Gauthier, Huebsch, Hughson, Jha, Kim, Kwon, Oikonomopoulos, Perhonen, Rogers, Sharma, Sharma, Sharma, Sides, Spotnitz, Sun, Thomason, Wnorowski, Wu, Yu   +30 more
core   +1 more source

Structural Kinetics of Cardiac Troponin C Mutants Linked to Familial Hypertrophic and Dilated Cardiomyopathy in Troponin Complexes*

Journal of Biological Chemistry, 2008
The key events in regulating cardiac muscle contraction involve Ca2+ binding to and release from cTnC (troponin C) and structural changes in cTnC and other thin filament proteins triggered by Ca2+ movement.
W. Dong, J. Xing, Yexin Ouyang, J. An, H. Cheung   +4 more
semanticscholar   +1 more source

Noradrenergic and cholinergic innervation of the normal human heart and changes associated with cardiomyopathy

The Anatomical Record, EarlyView.
Abstract Autonomic nerves are crucial in cardiac function and pathology. However, data on the distribution of cholinergic and noradrenergic nerves in normal and pathologic human hearts is lacking. Nonfailing donor hearts were pressure‐perfusion fixed, imaged, and dissected. Left ventricular cardiomyopathy samples were also obtained.
Peter Hanna, Donald B. Hoover, Logan G. Kirkland, Elizabeth H. Smith, Megan D. Poston, Stanley G. Peirce, Chloe G. Garbe, Tasha K. Phillips, Steven Cha, Shumpei Mori, Jaclyn A. Brennan, John Andrew Armour, Eric Rytkin, Igor R. Efimov, Olujimi A. Ajijola, Jeffrey L. Ardell, Kalyanam Shivkumar   +16 more
wiley   +1 more source

cNTnC and fYTnC2, Genetically Encoded Green Calcium Indicators Based on Troponin C from Fast Animals. [PDF]

Int J Mol Sci, 2022
Subach OM, Vlaskina AV, Agapova YK, Korzhenevskiy DA, Nikolaeva AY, Varizhuk AM, Subach MF, Patrushev MV, Piatkevich KD, Boyko KM, Subach FV.   +10 more
europepmc   +1 more source

Muscle Fatigue from the Perspective of a Single Crossbridge [PDF]

, 2016
The repeated intense stimulation of skeletal muscle rapidly decreases its force- and motion-generating capacity. This type of fatigue can be temporally correlated with the accumulation of metabolic by-products, including phosphate (Pi) and protons (H ...
Debold, Edward Patrick, Fitts, Robert H., Nosek, Thomas M., Sundberg, Christopher W.   +3 more
core   +1 more source

B cells and systemic sclerosis interstitial lung disease

Arthritis &Rheumatology, Accepted Article.
Interstitial lung disease is an important complication of systemic sclerosis (SSc‐ILD) with high mortality and morbidity. Recent clinical studies in SSc‐ILD have led to FDA‐approved therapies in SSc‐ILD. Importantly, evidence from these studies has been extrapolated to guide management of interstitial lung diseases of other systemic autoimmune ...
Nina Goldman, Voon Ong, Christopher Denton   +2 more
wiley   +1 more source

The effect of Mg²⁺ on Ca²⁺ binding to cardiac troponin C in hypertrophic cardiomyopathy associated TNNC1 variants. [PDF]

FEBS J, 2022
Rayani K, Hantz ER, Haji-Ghassemi O, Li AY, Spuches AM, Van Petegem F, Solaro RJ, Lindert S, Tibbits GF.   +8 more
europepmc   +1 more source

Determining predictors of underlying etiology and clinical deterioration in patients with physiologic instability in the emergency department [PDF]

, 2013
Thesis (M.A.)--Boston UniversityShock is a critical state defined by inadequate oxygen delivery to tissues. It is well known in the critical care community that early diagnosis and treatment of shock are crucial to improving patient outcomes. However, in
Day, Danielle E.
core   +1 more source