Nature Communications, 2016 Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin ...
Vikram Shettigar +19 more
doaj +2 more sources
Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils
Frontiers in Physiology, 2011 Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber ...
Sean C Little +4 more
doaj +2 more sources
Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study. [PDF]
Journal of Physical Chemistry B, 2012 Troponin C (TnC) is an important regulatory molecule in cardiomyocytes. Calcium binding to site II in TnC initiates a series of molecular events that result in muscle contraction.
Huber, Gary +4 more
core +3 more sources
Functional redundancy and nonredundancy between two Troponin C isoforms in Drosophila adult muscles. [PDF]
Mol Biol Cell, 2017 Knockout of either of two Drosophila Troponin C genes that are expressed in either the flight muscle or the jump muscle resulted in expansion of transcription of its paralogue into the affected muscle.
Chechenova MB +6 more
europepmc +2 more sources
Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation. [PDF]
Front Physiol, 2017 Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect Ca2+-regulation and function of slow skeletal muscle since the same gene is expressed ...
Veltri T +9 more
europepmc +2 more sources
Calmodulin-free skeletal-muscle troponin C prepared in the absence of urea [PDF]
Biochemical Journal, 1981 J A Cox, Michelle Comte, Eric A. Stein
openalex +2 more sources
Frontiers in Physiology, 2022 Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow ...
Zabed Mahmud +13 more
doaj +1 more source
Troponin Variants as Markers of Skeletal Muscle Health and Diseases
Frontiers in Physiology, 2021 Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric myofilament proteins are essential players in the contraction of striated muscles.
Monica Rasmussen +2 more
doaj +1 more source
The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus. [PDF]
PLoS ONE, 2015 Hibernation is an adaptive strategy used by various mammals to survive the winter under situations of low ambient temperatures and limited or no food availability.
Bryan E Luu +3 more
doaj +1 more source
The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]
Biochemistry, 2002 We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
Paul R. Rosevear +4 more
openaire +3 more sources