The enthalpy titration of troponin C with calcium
Biochimica et Biophysica Acta (BBA) - Protein Structure, 1978 Microcalorimetric titrations have been used to study the binding of Ca2+ to troponin C, the Ca-binding component of troponin. Troponin C was extracted from rabbit skeletal muscle and Ca2+ was added to Ca-free troponin C in the presence of 1 mM Mg2+ at pH 8.83 at 10 degrees C.
Kazuhiro Yamada
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Troponin Variants as Markers of Skeletal Muscle Health and Diseases
Frontiers in Physiology, 2021 Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric myofilament proteins are essential players in the contraction of striated muscles.
Monica Rasmussen +2 more
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The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus. [PDF]
PLoS ONE, 2015 Hibernation is an adaptive strategy used by various mammals to survive the winter under situations of low ambient temperatures and limited or no food availability.
Bryan E Luu +3 more
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The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]
Biochemistry, 2002 We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
Paul R. Rosevear +4 more
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The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation. [PDF]
J Biol Chem, 2019 Aberrant regulation of myocardial force production represents an early biomechanical defect associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly defined. Here, we evaluated the pathogenicity of a previously unreported sarcomeric gene variant identified in a pediatric patient with sporadic dilated cardiomyopathy, and ...
Johnston JR +13 more
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Interaction of bepridil with the cardiac troponin C/troponin I complex [PDF]
FEBS Letters, 2001 We have investigated the binding of bepridil to calcium‐saturated cardiac troponin C in a cardiac troponin C/troponin I complex. Nuclear magnetic resonance spectroscopy and [15N,2H]cardiac troponin C permitted the mapping of bepridil‐induced amide proton chemical shifts. A single bepridil‐binding site in the regulatory domain was found with an affinity
Ekram Abusamhadneh +5 more
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Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils
Frontiers in Physiology, 2011 Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber ...
Sean C Little +4 more
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Effects of temperature and method of heat treatment on myofibrillar proteins of pork [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2014 During the tests in this paper, meat processing was carried out at different temperatures between the range of 51°C to 100°C. The meat was processed by dry heat (roasting) and wet heat treatments (cooking) in water at atmospheric pressure. After
Vujadinović Dragan +3 more
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The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery [PDF]
Brazilian Journal of Cardiovascular Surgery, 2019 Objective: To evaluate the effect of high-dose vitamin C on cardiac reperfusion injury and plasma levels of creatine kinase-muscle/brain (CK-MB), troponin I, and lactate dehydrogenase (LDH) in patients undergoing coronary artery bypass grafting (CABG ...
Nafiseh Emadi +3 more
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Clinics, 2015 Elevated serum levels of cardiac troponin and C-reactive protein are associated with all-cause and cardiovascular mortality in patients with end-stage renal disease.
Wei-Jie Li +6 more
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