The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation. [PDF]
J Biol Chem, 2019 Aberrant regulation of myocardial force production represents an early biomechanical defect associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly defined.
Johnston JR +13 more
europepmc +2 more sources
Functional redundancy and nonredundancy between two Troponin C isoforms in Drosophila adult muscles. [PDF]
Mol Biol Cell, 2017 Knockout of either of two Drosophila Troponin C genes that are expressed in either the flight muscle or the jump muscle resulted in expansion of transcription of its paralogue into the affected muscle.
Chechenova MB +6 more
europepmc +2 more sources
Hypertrophic Cardiomyopathy Cardiac Troponin C Mutations Differentially Affect Slow Skeletal and Cardiac Muscle Regulation. [PDF]
Front Physiol, 2017 Mutations in TNNC1—the gene encoding cardiac troponin C (cTnC)—that have been associated with hypertrophic cardiomyopathy (HCM) and cardiac dysfunction may also affect Ca2+-regulation and function of slow skeletal muscle since the same gene is expressed ...
Veltri T +9 more
europepmc +2 more sources
Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils [PDF]
Front. Physio., 2011 Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber ...
Davis, Jonathan P. +4 more
core +4 more sources
Troponin C Mutations Partially Stabilize the Active State of Regulated Actin and Fully Stabilize the Active State When Paired with Δ14 TnT. [PDF]
Biochemistry, 2017 Striated muscle contraction is regulated by the actin-associated proteins tropomyosin and troponin. The extent of activation of myosin ATPase activity is lowest in the absence of both Ca2+ and activating cross-bridges (i.e., S1-ADP or rigor S1).
Baxley T +3 more
europepmc +2 more sources
Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease. [PDF]
Nat Commun, 2016 Treatment for heart disease, the leading cause of death in the world, has progressed little for several decades. Here we develop a protein engineering approach to directly tune in vivo cardiac contractility by tailoring the ability of the heart to ...
Shettigar V +19 more
europepmc +2 more sources
Toward Understanding the Molecular Bases of Stretch Activation: A STRUCTURAL COMPARISON OF THE TWO TROPONIN C ISOFORMS OF LETHOCERUS. [PDF]
J Biol Chem, 2016 Muscles are usually activated by calcium binding to the calcium sensory protein troponin-C, which is one of the three components of the troponin complex.
Sanfelice D +4 more
europepmc +7 more sources
Dynamics and calcium association to the N-terminal regulatory domain of human cardiac troponin C: a multiscale computational study. [PDF]
Journal of Physical Chemistry B, 2012 Troponin C (TnC) is an important regulatory molecule in cardiomyocytes. Calcium binding to site II in TnC initiates a series of molecular events that result in muscle contraction.
Huber, Gary +4 more
core +3 more sources
FIM: A fatigued-injured muscle model based on the sliding filament theory [PDF]
Computers in Biology and Medicine, 2023, 164, pp.107367, 2023 Skeletal muscle modeling has a vital role in movement studies and the development of therapeutic approaches. In the current study, a Huxley-based model for skeletal muscle is proposed, which demonstrates the impact of impairments in muscle characteristics.
arxiv +1 more source
Amino Acid Changes at Arginine 204 of Troponin I Result in Increased Calcium Sensitivity of Force Development. [PDF]
, 2016 Mutations in human cardiac troponin I (cTnI) have been associated with restrictive, dilated, and hypertrophic cardiomyopathies. The most commonly occurring residue on cTnI associated with familial hypertrophic cardiomyopathy (FHC) is arginine (R), which ...
Cui, Ziyou +4 more
core +5 more sources