Results 11 to 20 of about 88,882 (294)

The enthalpy titration of troponin C with calcium

open access: bronzeBiochimica et Biophysica Acta (BBA) - Protein Structure, 1978
Microcalorimetric titrations have been used to study the binding of Ca2+ to troponin C, the Ca-binding component of troponin. Troponin C was extracted from rabbit skeletal muscle and Ca2+ was added to Ca-free troponin C in the presence of 1 mM Mg2+ at pH 8.83 at 10 degrees C.
Kazuhiro Yamada
openalex   +4 more sources

Troponin Variants as Markers of Skeletal Muscle Health and Diseases

open access: yesFrontiers in Physiology, 2021
Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric myofilament proteins are essential players in the contraction of striated muscles.
Monica Rasmussen   +2 more
doaj   +1 more source

The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus. [PDF]

open access: yesPLoS ONE, 2015
Hibernation is an adaptive strategy used by various mammals to survive the winter under situations of low ambient temperatures and limited or no food availability.
Bryan E Luu   +3 more
doaj   +1 more source

The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]

open access: yesBiochemistry, 2002
We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
Paul R. Rosevear   +4 more
openaire   +3 more sources

The intrinsically disordered C terminus of troponin T binds to troponin C to modulate myocardial force generation. [PDF]

open access: yesJ Biol Chem, 2019
Aberrant regulation of myocardial force production represents an early biomechanical defect associated with sarcomeric cardiomyopathies, but the molecular mechanisms remain poorly defined. Here, we evaluated the pathogenicity of a previously unreported sarcomeric gene variant identified in a pediatric patient with sporadic dilated cardiomyopathy, and ...
Johnston JR   +13 more
europepmc   +5 more sources

Interaction of bepridil with the cardiac troponin C/troponin I complex [PDF]

open access: yesFEBS Letters, 2001
We have investigated the binding of bepridil to calcium‐saturated cardiac troponin C in a cardiac troponin C/troponin I complex. Nuclear magnetic resonance spectroscopy and [15N,2H]cardiac troponin C permitted the mapping of bepridil‐induced amide proton chemical shifts. A single bepridil‐binding site in the regulatory domain was found with an affinity
Ekram Abusamhadneh   +5 more
openaire   +3 more sources

Measurement of Calcium Dissociation Rates from Troponin C in Rigor Skeletal Myofibrils

open access: yesFrontiers in Physiology, 2011
Ca2+ dissociation from the regulatory domain of troponin C may influence the rate of striated muscle relaxation. However, Ca2+ dissociation from troponin C has not been measured within the geometric and stoichiometric constraints of the muscle fiber ...
Sean C Little   +4 more
doaj   +1 more source

Effects of temperature and method of heat treatment on myofibrillar proteins of pork [PDF]

open access: yesChemical Industry and Chemical Engineering Quarterly, 2014
During the tests in this paper, meat processing was carried out at different temperatures between the range of 51°C to 100°C. The meat was processed by dry heat (roasting) and wet heat treatments (cooking) in water at atmospheric pressure. After
Vujadinović Dragan   +3 more
doaj   +1 more source

The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery [PDF]

open access: yesBrazilian Journal of Cardiovascular Surgery, 2019
Objective: To evaluate the effect of high-dose vitamin C on cardiac reperfusion injury and plasma levels of creatine kinase-muscle/brain (CK-MB), troponin I, and lactate dehydrogenase (LDH) in patients undergoing coronary artery bypass grafting (CABG ...
Nafiseh Emadi   +3 more
doaj   +1 more source

Cardiac troponin and C-reactive protein for predicting all-cause and cardiovascular mortality in patients with chronic kidney disease: A meta-analysis

open access: yesClinics, 2015
Elevated serum levels of cardiac troponin and C-reactive protein are associated with all-cause and cardiovascular mortality in patients with end-stage renal disease.
Wei-Jie Li   +6 more
doaj   +1 more source

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