Frontiers in Physiology, 2022 Small molecule cardiac troponin activators could potentially enhance cardiac muscle contraction in the treatment of systolic heart failure. We designed a small molecule, RPI-194, to bind cardiac/slow skeletal muscle troponin (Cardiac muscle and slow ...
Zabed Mahmud +13 more
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Troponin Variants as Markers of Skeletal Muscle Health and Diseases
Frontiers in Physiology, 2021 Ca2+-regulated contractility is a key determinant of the quality of muscles. The sarcomeric myofilament proteins are essential players in the contraction of striated muscles.
Monica Rasmussen +2 more
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The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]
Biochemistry, 2002 We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
William T, Heller +4 more
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The regulation of troponins I, C and ANP by GATA4 and Nkx2-5 in heart of hibernating thirteen-lined ground squirrels, Ictidomys tridecemlineatus. [PDF]
PLoS ONE, 2015 Hibernation is an adaptive strategy used by various mammals to survive the winter under situations of low ambient temperatures and limited or no food availability.
Bryan E Luu +3 more
doaj +1 more source
Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: The role of the C- and N-terminal extensions [PDF]
, 2007 The aim of this study is to investigate the function of the C-terminal extension of three troponin I isoforms, that are unique to the body wall muscles of Caenorhabditis elegans and to understand the molecular interactions within the TN complex between ...
al-Hillawi +35 more
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Effects of temperature and method of heat treatment on myofibrillar proteins of pork [PDF]
Chemical Industry and Chemical Engineering Quarterly, 2014 During the tests in this paper, meat processing was carried out at different temperatures between the range of 51°C to 100°C. The meat was processed by dry heat (roasting) and wet heat treatments (cooking) in water at atmospheric pressure. After
Vujadinović Dragan +3 more
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Drug Binding to Cardiac Troponin C [PDF]
Journal of Biological Chemistry, 1999 Compounds that sensitize cardiac muscle to Ca(2+) by intervening at the level of regulatory thin filament proteins would have potential therapeutic benefit in the treatment of myocardial infarctions. Two putative Ca(2+) sensitizers, EMD 57033 and levosimendan, are reported to bind to cardiac troponin C (cTnC).
Q, Kleerekoper, J A, Putkey
openaire +2 more sources
Clinics, 2015 Elevated serum levels of cardiac troponin and C-reactive protein are associated with all-cause and cardiovascular mortality in patients with end-stage renal disease.
Wei-Jie Li +6 more
doaj +1 more source
The Effect of High-Dose Vitamin C on Biochemical Markers of Myocardial Injury in Coronary Artery Bypass Surgery [PDF]
Brazilian Journal of Cardiovascular Surgery, 2019 Objective: To evaluate the effect of high-dose vitamin C on cardiac reperfusion injury and plasma levels of creatine kinase-muscle/brain (CK-MB), troponin I, and lactate dehydrogenase (LDH) in patients undergoing coronary artery bypass grafting (CABG ...
Nafiseh Emadi +3 more
doaj +1 more source
Biomarkers in acute coronary syndromes and their role in diabetic patients [PDF]
, 2005 Diabetic patients with acute coronary syndromes are at high risk for cardiovascular complications but risk stratification in these patients remains challenging.
Christopher Heeschen +5 more
core +1 more source