Results 21 to 30 of about 18,693,880 (254)

Disease-related cardiac troponins alter thin filament Ca2+ association and dissociation rates. [PDF]

PLoS ONE, 2012
The contractile response of the heart can be altered by disease-related protein modifications to numerous contractile proteins. By utilizing an IAANS labeled fluorescent troponin C, [Formula: see text], we examined the effects of ten disease-related ...
Bin Liu, Svetlana B Tikunova, Kristopher P Kline, Jalal K Siddiqui, Jonathan P Davis   +4 more
doaj   +1 more source

False-positive troponin elevation due to an immunoglobulin-G-cardiac troponin T complex: a case report [PDF]

, 2020
Background Troponin is a crucial biomarker for the diagnosis of an acute coronary syndrome (ACS). It rises in response to myocardial injury from significant acute myocardial ischaemia caused by obstructive coronary artery disease [‘classical’ myocardial
Firoozi, S, Akhtar, Z., Shanmugam, N, Dargan, J, Gaze, D.C., Dargan, J., Collinson, P., Shanmugam, N., Akhtar, Z, Collinson, P, Gaze, D, Firoozi, S.   +11 more
core   +1 more source

Genetically Encoded Calcium Indicators Based on Troponin C and Fluorescent Proteins [PDF]

, 2005
Genetically encoded calcium probes allow the visualization and quantification of intracellular calcium dynamics with great specificity and sensitivity.
Heim, Nicola
core   +1 more source

Differentiation between myopericarditis and acute myocardial infarction on presentation in the emergency department using the admission C-reactive protein to troponin ratio.

PLoS ONE, 2021
BackgroundThe treatment of myopericarditis is different than that of acute myocardial infarction (AMI). However, since their clinical presentation is frequently similar it may be difficult to distinguish between these entities despite a disparate ...
Simcha R Meisel, Hamuda Nashed, Randa Natour, Rami Abu Fanne, Majdi Saada, Naama Amsalem, Carmel Levin, Ofer Kobo, Aaron Frimerman, Yaniv Levi, Jameel Mohsen, Avraham Shotan, Ariel Roguin, Michael Kleiner-Shochat   +13 more
doaj   +1 more source

Evaluation of troponin I and C in horses intoxicated by salinomycin

Pesquisa Veterinária Brasileira, 2023
: Ionophores are antibiotics frequently used in animals of production. The most common are monensin, salinomycin, narasin, and lasalocid. The equine species is highly susceptible to ionophores poisoning.
Camila B. Pohl, Bianca S. Cecco, Luan C. Henker, Marcele B. Bandinelli, Ronaldo M. Bianchi, Welden Panziera, Saulo P. Pavarini, David Driemeier   +7 more
doaj   +1 more source

High-sensitivity troponin I concentrations are a marker of an advanced hypertrophic response and adverse outcomes in patients with aortic stenosis [PDF]

, 2014
AIMS: High-sensitivity cardiac troponin I (cTnI) assays hold promise in detecting the transition from hypertrophy to heart failure in aortic stenosis.
Lang, Chim C., Langrish, Jeremy P, Langrish, Jeremy P., Newby, David E., Shah, Anoop, Dweck, Marc R, Alam, Shirjel, Mills, Nicholas L; id_orcid, McAllister, David A, Hunter, Amanda L., Cowell, S. Joanna, Boon, Nicholas A, Shah, Anoop S.V., Strachan, Fiona E, McAllister, David A., Maria Choy, Anna; id_orcid, Strachan, Fiona E., Boon, Nicholas A., Mills, Nicholas L., Dweck, Marc R., Shah, Anoop S. V., Newby, David E, Lang, Chim C.; id_orcid, Chin, Calvin W.L., Chin, Calvin W L, Chin, Calvin W. L., Joanna Cowell, S, Maria Choy, Anna, Walker, Simon, Lang, Chim C, Hunter, Amanda L   +30 more
core   +1 more source

Levosimendan in Cardiogenic Shock: A Review of Mechanisms, Clinical Evidence, and Therapeutic Use

Reviews in Cardiovascular Medicine
Levosimendan is a calcium-sensitizing inodilator that has attracted renewed attention for a potential role in the management of cardiogenic shock (CS).
Stefano Salvini, Valeria Trivelloni, Ilenia Monaco, Fatima Samet Bouhaik, Insaf Chouarfia, Iheb Guefrachi, Yassine Bencharef, Mounia Sedrati, Charaf Mouhand, Dario Bottigliero   +9 more
doaj   +1 more source

Rationally engineered Troponin C modulates in vivo cardiac function and performance in health and disease

Nature Communications, 2016
Heart contraction, which is decreased in disease, is determined by Ca2+binding to troponin C. Here, the authors combine a protein engineering approach with gene therapy to modulate heart contractility in mice with the use of rationally designed Troponin ...
Vikram Shettigar, Bo Zhang, Sean C. Little, Hussam E. Salhi, Brian J. Hansen, Ning Li, Jianchao Zhang, Steve R. Roof, Hsiang-Ting Ho, Lucia Brunello, Jessica K. Lerch, Noah Weisleder, Vadim V. Fedorov, Federica Accornero, Jill A. Rafael-Fortney, Sandor Gyorke, Paul M. L. Janssen, Brandon J. Biesiadecki, Mark T. Ziolo, Jonathan P. Davis   +19 more
doaj   +1 more source

Irisin regulates cardiac physiology in zebrafish.

PLoS ONE, 2017
Irisin is a myokine encoded in its precursor fibronectin type III domain containing 5 (FNDC5). It is abundantly expressed in cardiac and skeletal muscle, and is secreted upon the activation of peroxisome proliferator-activated receptor gamma coactivator ...
Lakshminarasimhan Sundarrajan, Chanel Yeung, Logan Hahn, Lynn P Weber, Suraj Unniappan   +4 more
doaj   +1 more source

Familial hypertrophic cardiomyopathy related cardiac troponin C L29Q mutation alters length-dependent activation and functional effects of phosphomimetic troponin I*. [PDF]

PLoS ONE, 2013
The Ca(2+) binding properties of the FHC-associated cardiac troponin C (cTnC) mutation L29Q were examined in isolated cTnC, troponin complexes, reconstituted thin filament preparations, and skinned cardiomyocytes. While higher Ca(2+) binding affinity was
Alison Y Li, Charles M Stevens, Bo Liang, Kaveh Rayani, Sean Little, Jonathan Davis, Glen F Tibbits   +6 more
doaj   +1 more source