Results 51 to 60 of about 18,693,880 (254)

Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain.

PLoS ONE, 2020
BackgroundDespite the use of high-sensitive cardiac troponin there remains a group of high-sensitive cardiac troponin negative patients with unstable angina with a non-neglectable risk for future adverse cardiovascular events, emphasising the need for ...
Mirthe Dekker, Farahnaz Waissi, Joelle van Bennekom, Max J M Silvis, Nathalie Timmerman, Arjan H Schoneveld, Diederick E Grobbee, Robbert J de Winter, Arend Mosterd, Leo Timmers, Dominique P V de Kleijn   +10 more
doaj   +1 more source

Microfluidic Droplet Plate Preserving Single Human Induced Pluripotent Stem Cell‐Derived Cardiomyocytes Morphology and Function

Advanced Materials Technologies, EarlyView.
We introduce a novel method combining microfluidics, optogenetics, and human induced pluripotent stem cell (iPSC) technology to encapsulate single iPSC‐derived cardiomyocytes (iPSC‐CMs) in an optimal environment for functional characterization. This method enables direct genotype‐phenotype correlation for genetic studies and high‐throughput screening ...
Xiao‐Ting Wang, Rachel P. White, Yashasvi Tharani, Michael A. Finocchiaro, Leona M. Ripple, Maksymilian Prondzynski, Tania Konry, Vassilios J. Bezzerides   +7 more
wiley   +1 more source

Blood C‐peptide concentration as a proxy marker of cardiovascular disease: An observational cross‐sectional study

Health Science Reports, 2023
Background and Aims Cardiovascular diseases (CVDs) are among the leading causes of disability and early death in sub‐Saharan Africa. Most of the current blood tests for CVD diagnosis involve performing about three test profiles; often at additional cost ...
Laurinda Adusu‐Donkor, Emmanuel Kwaku Ofori, Fleischer C. N. Kotey, Francis Kwaku Dogodzi, Wormenor Dziedzorm, Alfred Buabeng, Segla Kwame Bernard, Seth K. Amponsah, Henry Asare‐Anane   +8 more
doaj   +1 more source

Mouse Models of Cardiomyopathies Caused by Mutations in Troponin C

, 2023
Cardiac muscle contraction is regulated via Ca2+ exchange with the hetero-trimeric troponin complex located on the thin filament. Binding of Ca2+ to cardiac troponin C, a Ca2+ sensing subunit within the troponin complex, results in a series of ...
Jonathan P. Davis, Svetlana B. Tikunova, Jenna Thuma   +2 more
core   +1 more source

Release and Clearance Mechanisms of Cardiac Troponin [PDF]

, 2020
Myocardial infarction (MI) is often suspected when a patient presents with chest pain. MI is defined as cardiac necrosis due to ischemia, most often mediated through impaired coronary perfusion.
Karin, Starnberg
core   +1 more source

ZER1 Restrains Pressure Overload‐Induced Cardiac Remodeling by Targeting DVL2 for Gly/N‐Degron‐Dependent Degradation

Advanced Science, EarlyView.
Pressure overload suppresses cardiomyocyte ZER1, weakening CRL2Zer1‐mediated DVL2 degradation and allowing DVL2 accumulation. Elevated DVL2 activates CaMKII‐HDAC4‐MEF2C signaling, drives fetal gene reactivation, and promotes pathological remodeling.
Mingchao Jiang, Zhehao Lin, Lu Chen, Ying Ni, Jun Zhou, Wenjuan Zhang, Huilin Wang, Peifeng Ying, Xiu Lu, Kai Wang, Qingran Kong, Naxin Xu, Dingsheng Zhao, Jianwei Li, Guohui Zhong, Xingchen Meng, Sarkawt Hamad, Junmeng Zheng, Yuan Fu, Rongjiang Qin, Xuran Chu, Shangxuan Li, Youyou Li, Yili Wu, Yi Wang, Weihong Song, Yingxian Li, Shukuan Ling   +27 more
wiley   +1 more source

The HEART score has less utility with high sensitivity troponin

Frontiers in Cardiovascular Medicine
BackgroundClinical risk scores for acute chest pain evaluation were largely validated using older troponin assays. We sought to analyze the HEART score and clinical decision pathways utilizing high sensitivity troponin.MethodsThis was a retrospective ...
Austin Harris, Kory Heier, Jeffrey F. Spindel, Weston McCowan, Emily Slade, Mansi Parekh, Dealla Samadi, Vedant Gupta   +7 more
doaj   +1 more source

The importance of intrinsically disordered segments of cardiac troponin in modulating function by phosphorylation and disease-causing mutations

Frontiers in Physiology, 2016
Troponin plays a central role in regulation of muscle contraction. It is the Ca2+ switch of striated muscles including the heart and in the cardiac muscle is physiologically modulated by PKA-dependent phosphorylation at Ser22 and 23.
Maria Papadaki, Steven Baxter Marston
doaj   +1 more source

Single‐Cell and Spatial Transcriptomics Unveil Key Regulators Governing Cell Differentiation for Schistosoma japonicum Sexual Development

Advanced Science, EarlyView.
Using single‐cell and spatial transcriptomics, we identified key regulators that govern cell differentiation involved in parasite development and egg laying in Schistosoma japonicum. This comprehensive study establishes a foundational resource for understanding schistosome biology, deciphers the regulatory programs underlying cell differentiation and ...
Zhigang Lu, Xiaoxu Wang, Shun Li, Xuxin Li, Pengfei Du, Yameng Zheng, Lu Liu, Yanyan Zhang, Omri Wurtzel, Guofeng Cheng   +9 more
wiley   +1 more source

Serum troponin, D‐dimer, and CRP level in severe coronavirus (COVID‐19) patients

Immunity, Inflammation and Disease, 2022
Background Abnormal inflammation coagulation biomarker levels of troponin, C‐reactive protein (CRP), and D‐dimer levels in serum have been demonstrated to be associated and involved in the disease progression of coronavirus disease 2019 (COVID‐19 ...
Ayad M. Ali, Hassan M. Rostam, Mohammed H. Fatah, Chalak M. Noori, Kameran M. Ali, Hassan M. Tawfeeq   +5 more
doaj   +1 more source