Results 61 to 70 of about 18,693,880 (254)

Cardiac troponin I inhibitory peptide: location of interaction sites on troponin C [PDF]

, 2000
Cardiac troponin I(129–149) binds to the calcium saturated cardiac troponin C/troponin I(1–80) complex at two distinct sites. Binding of the first equivalent of troponin I(129–149) was found to primarily affect amide proton chemical shifts in the ...
M.Bret Abbott, Alex Dvoretsky, Paul R Rosevear, Gaponenko, Vadim, Abbott, M.Bret, Rosevear, Paul R, Vadim Gaponenko, Dvoretsky, Alex   +7 more
core   +1 more source

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

False positive troponin: A true problem [PDF]

Journal of Medical Biochemistry, 2013
Cardiac troponins have a crucial role in diagnosing acute myocardial infarction, but have been considered by some authors to have a high false positive rate. Such opinions may decrease the confidence in troponin with important clinical consequences.
Koraćević Goran, Ćosić Vladan, Stojanović Ivana   +2 more
doaj  

Nucleoside‐Modified mRNA Encoding Alpha‐Galactosidase A Ameliorates Fabry Disease Phenotypes in Human IPSC‐Derived Cardiomyocytes

Advanced Science, EarlyView.
Human iPSC‐derived Fabry cardiomyocytes exhibited broad transcriptional dysregulation, apoptosis, mitochondrial dysfunction, impaired reactive oxygen species handling, altered contractility, and abnormal calcium transient decay, potentially mediated by phospholamban hyperphosphorylation.
Malte Juchem, Lea Oehlsen, Sedef Ersoy, Jia Li Ye, Natalie Weber, Elisa Mohr, Wilson Agyapong, Junqing Liu, Maximilian Fuchs, Ke Xiao, Christopher Jahn, Reto Eggenschwiler, Tobias Cantz, Julia Beimdiek, Falk F. R. Buettner, Theresia Kraft, Jan Hegermann, Ivonne J. Knorr, Lisa Ernst, Linda Feldbrügge, Resa Puffert, Kevin Schmidt, Christian Bär, Jeannine Hoepfner, Thomas Thum   +24 more
wiley   +1 more source

Study of Plasma Malondialdehyde, Troponin I and C - Reactive protein in Acute Coronary Syndromes Patients

پزشکی بالینی ابن سینا, 2006
Introduction & Objective: Ischemic injury of endothelium is associated with prostaglandin synthesis and platelet adhesion and aggregation, which may be associated with the release of aldehydes such as malondialdehyde (MDA). C-reactive protein and cardiac
Safar Shams, Mohammad Reza Safari, Mohsen Gharakhani, Mohammad Hosein Rahimi, Shahram Houmayonfar, Behshad Naghsh Tabrizi, Farzad Emami   +6 more
doaj  

Characteristics of Uremic Cardiomyopathy with Reversible Systolic Dysfunction [PDF]

, 2009
Background: There exists a sub group of patients with uremic cardiomyopathy who experience resolution of heart failure following hemodialysis.
Shamanna Iyengar, Srilakshmi Adhyapak
core  

CDK4/MERCs/PINK1 Axis Drives PFOA/HFPO‐TA‐Induced Cardiac Senescence via Mitophagy Defect and cGAS‐STING Activation: In Vitro Amelioration by Cycloastragenol

Advanced Science, EarlyView.
The present study demonstrated that PFOA and HFPO‐TA exposure suppressed CDK4, disrupted MERCs and impaired PINK1/Parkin‐mediated mitophagy, thereby accelerating cardiac senescence, whereas CAG effectively reversed these pathological changes in vitro. Our findings identify CDK4 as a critical regulator bridging mitophagy defects and cardiac senescence ...
Nuo‐Wa Li, Jun‐Ze Jiang, Ying‐Ying Liu, Tian‐Tian Zhang, Kanwar Kumar Malhi, Xin Yao, Jin‐Long Li   +6 more
wiley   +1 more source

Molecular dynamics simulations of the cardiac troponin complex performed with FRET distances as restraints. [PDF]

PLoS ONE, 2014
Cardiac troponin (cTn) is the Ca(2+)-sensitive molecular switch that controls cardiac muscle activation and relaxation. However, the molecular detail of the switching mechanism and how the Ca(2+) signal received at cardiac troponin C (cTnC) is ...
Jayant James Jayasundar, Jun Xing, John M Robinson, Herbert C Cheung, Wen-Ji Dong   +4 more
doaj   +1 more source

Macrophage PARP7 Alleviates Septic Cardiomyopathy by Interacting With TBK1 and Suppressing TBK1‐Driven Inflammatory Response

Advanced Science, EarlyView.
In septic cardiomyopathy, PARP7 directly binds TBK1 and mediates its ADP‐ribosylation, thereby repressing TBK1‐driven proinflammatory signaling in macrophages. ABSTRACT Septic cardiomyopathy is a life‐threatening complication of sepsis, and an uncontrolled inflammatory response represents a key pathogenic mechanism. PARP7 negatively regulates the IFN‐I
Jibo Han, Lintao Wang, Xin Zhong, Shenggang Zhao, Huihui Xie, Xue Han, Liming Lin, Yiting Lyu, Ke Xu, Jiajun Xu, Xiaowen Shi   +10 more
wiley   +1 more source

Medicolegal Use of Troponin C Expression to Identify Different Causes of Cardiac Deaths at Different Postmortem Intervals [PDF]

Zagazig Journal of Forensic Medicine and Toxicology, 2019
Identification of the exact cause and time of death are important questions that have to be answered by the forensic pathologist. Traumatic cardiac injuries is a leading cause of death.
Nermien Ibrahim
doaj   +1 more source