Results 61 to 70 of about 166,646 (357)

A Systemic Selective Modified mRNA Delivery Platform for Preventing Chemotherapy‐Induced Cardiotoxicity

Advanced Science, EarlyView.
In Yoo and Mainkar et al., we present a minimally invasive, CM‐selective modRNA delivery system encapsulated in lipid nanoparticles for intravenous (IV) administration. This platform enables selective cardiac translation of therapeutic modRNA but suppresses expression in off‐target tissues, including tumors.
Jimeen Yoo, Gayatri Mainkar, Matteo Ghiringhelli, Bernardo Gindri Dos Santos, Magdalena M. Żak, Keerat Kaur, Ann Anu Kurian, Matthew Adjmi, Segev Sharon, Eftychia Markopoulou, Lucia Žigová, Daniela Hirsch, Sydney Pessin, Rachel Hanan, Juan Luis Escano Abreu, Niki Brisnovali, Nicole Dubois, Leigh Goedeke, Mengcheng Shen, Lior Zangi   +19 more
wiley   +1 more source

The importance of intrinsically disordered segments of cardiac troponin in modulating function by phosphorylation and disease-causing mutations

Frontiers in Physiology, 2016
Troponin plays a central role in regulation of muscle contraction. It is the Ca2+ switch of striated muscles including the heart and in the cardiac muscle is physiologically modulated by PKA-dependent phosphorylation at Ser22 and 23.
Maria Papadaki, Steven Baxter Marston
doaj   +1 more source

Extracellular Vesicle cystatin c is associated with unstable angina in troponin negative patients with acute chest pain.

PLoS ONE, 2020
BackgroundDespite the use of high-sensitive cardiac troponin there remains a group of high-sensitive cardiac troponin negative patients with unstable angina with a non-neglectable risk for future adverse cardiovascular events, emphasising the need for ...
Mirthe Dekker, Farahnaz Waissi, Joelle van Bennekom, Max J M Silvis, Nathalie Timmerman, Arjan H Schoneveld, Diederick E Grobbee, Robbert J de Winter, Arend Mosterd, Leo Timmers, Dominique P V de Kleijn   +10 more
doaj   +1 more source

Serum troponin, D‐dimer, and CRP level in severe coronavirus (COVID‐19) patients

Immunity, Inflammation and Disease, 2022
Background Abnormal inflammation coagulation biomarker levels of troponin, C‐reactive protein (CRP), and D‐dimer levels in serum have been demonstrated to be associated and involved in the disease progression of coronavirus disease 2019 (COVID‐19 ...
Ayad M. Ali, Hassan M. Rostam, Mohammed H. Fatah, Chalak M. Noori, Kameran M. Ali, Hassan M. Tawfeeq   +5 more
doaj   +1 more source

High-sensitivity cardiac troponin T and copeptin assays to improve diagnostic accuracy of exercise stress test in patients with suspected coronary artery disease [PDF]

, 2014
Background: The average diagnostic sensitivity of exercise stress tests (ESTs) is lower than that of other non-invasive cardiac stress tests. The aim of the study was to examine whether high-sensitivity cardiac troponin T (hs-cTnT) or copeptin ...
Dörr, Oliver, Gaede, Luise, Hamm, Christian W., Hoffmann, Jedrzej, Liebetrau, Christoph, Möllmann, Helge, Nef, Holger M., Rolf, Andreas, Weber, Michael, Wolter, Jan S.   +9 more
core   +1 more source

PARPi Combining Nanoparticle LIN28B siRNA for the Management of Malignant Ascites

Advanced Science, EarlyView.
This study demonstrates that co‐inhibition of LIN28B and PARP using siLin28b/DSSP@lip‐PEG‐FA nanoparticles in combination with the PARP inhibitor BMN673 effectively suppresses the accumulation of malignant ascites associated with advanced cancers.
Yan Fang, Qian Shen, Yao Lin, Jing Zhu, Xiaolan Zhu, Rui Huang, Yijia Wu, Feiyang Shen, Qian Li, Guopei Zheng, Zhe Zhang, Qian Chu, Junhao Hu, Jianfeng Shen   +13 more
wiley   +1 more source

Incidence and prognosis associated with troponin elevation after cardiac surgery: a prospective cohort study

BMJ Open, 2022
Objective Cardiac troponin is used as a prognostic biomarker after cardiac surgery. However, numerous confounding elements, such as inflammation, liver and renal function biomarkers, have been associated with troponin variations.
Arthur Clement, Lee S Nguyen, Anousone Daulasim, Magali Souibri   +3 more
doaj   +1 more source

Reprogramming the Myocardial Infarction Conductive Microenvironment with Superconductive Ionic Patch for Cardiac Function Repair

Advanced Science, EarlyView.
A super‐conductive ionic patch reprograms the post‐infarction microenvironment by enabling stable ionic migration and electrical signal transmission within damaged myocardium. The patch rapidly adheres to cardiac tissue, enhances conduction velocity, suppresses excitation‐contraction decoupling, and promotes structural and functional cardiac repair in ...
Changyong Wang, Zhuang Zhang, Qi Yin, Changgeng Xu, Linlin Liang, Siwei Li, Yuwei Zhao, Chunlan Wang, Jin Zhou   +8 more
wiley   +1 more source

Utility of B-type natriuretic peptide in predicting medium-term mortality in patients undergoing major non-cardiac surgery [PDF]

, 2007
We assessed the ability of pre-operative B-type natriuretic peptide (BNP) levels to predict medium-term mortality in patients undergoing major noncardiac surgery.
Amiri, Amir R., Brittenden, Julie, Croal, Bernard L., Cuthbertson, Brian, Hillis, Graham S., Rajagopalan, Sriram   +5 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source