Results 101 to 110 of about 86,589 (350)

Infantile restrictive cardiomyopathy: cTnI-R170G/W impair the interplay of sarcomeric proteins and the integrity of thin filaments.

PLoS ONE, 2020
TNNI3 encoding cTnI, the inhibitory subunit of the troponin complex, is the main target for mutations leading to restrictive cardiomyopathy (RCM). Here we investigate two cTnI-R170G/W amino acid replacements, identified in infantile RCM patients, which ...
Diana Cimiotti, Setsuko Fujita-Becker, Desirée Möhner, Natalia Smolina, Heidi Budde, Aline Wies, Lisa Morgenstern, Alexandra Gudkova, Thomas Sejersen, Gunnar Sjöberg, Andreas Mügge, Marc M Nowaczyk, Peter Reusch, Gabriele Pfitzer, Robert Stehle, Rasmus R Schröder, Hans G Mannherz, Anna Kostareva, Kornelia Jaquet   +18 more
doaj   +1 more source

Probabilistic classification of acute myocardial infarction from multiple cardiac markers [PDF]

, 2008
Logistic regression and Gaussian mixture model (GMM) classifiers have been trained to estimate the probability of acute myocardial infarction (AMI) in patients based upon the concentrations of a panel of cardiac markers.
C Bishop, F Dombal de, F Fesmire, F Fesmire, George W. Irwin, H Selker, J Ellenuis, J Habbema, J Habbema, J Habbema, J Hanley, J Hilden, J Hilden, John V. Lamont, L Goldman, L Goldman, M Pozen, Paul C. Wilson, Robert F. Harrison, T Groth, W Tierney   +20 more
core   +1 more source

Muscle Organoids Reveal Exercise‐Like Contractions Rapidly Promote Muscle Health Via Lamtor1's Signaling to Both AMPK and mTOR

Advanced Science, EarlyView.
This study develops a novel 3D human skeletal muscle organoid platform to study the immediate molecular effects of exercise‐like contractions. The model uncovers rapid proteomic and transcriptomic responses, resolving a fundamental paradox by demonstrating how exercise‐induced Lamtor1 coordinately activates both AMPK and mTORC1. Lamtor1 is a compelling
Ziyue Yao, Zongmin Jiang, Xupeng Liu, Liping Zhang, Siyu Guo, Yu Chen, Lanfang Luo, Shilin Ma, Peng Wang, Ng Shyh‐Chang   +9 more
wiley   +1 more source

Age- and activity-related differences in the abundance of Myosin essential and regulatory light chains in human muscle [PDF]

, 2016
Traditional methods for phenotyping skeletal muscle (e.g., immunohistochemistry) are labor-intensive and ill-suited to multixplex analysis, i.e., assays must be performed in a series. Addressing these concerns represents a largely unmet research need but
Burniston, Jatin G., Close, Graeme L., Cobley, James N., Edwards, Ben J., Malik, Zulezwan Ab., Morton, James P.   +5 more
core   +4 more sources

FMO2 Promotes Angiogenesis via Regulation of N‐Acetylornithine

Advanced Science, EarlyView.
This study identifies flavin‐containing monooxygenase 2 (FMO2) as a novel proangiogenic regulator in endothelial cells. Targeted FMO2 ablation impairs vessel sprouting, whereas its compensation potently enhances angiogenesis. Metabolomics and single‐cell sequencing reveal that FMO2 drives vascular growth via the N‐acetylornithine/ATF3/NOTCH1 axis ...
Jingyi Wang, Yinghui Xu, Xianpeng Wu, Mo Li, Changchen Xiao, Zaiyang Fu, Yongjian Chen, Qingju Li, Yating Ruan, Jing Zhao, Zhiwei Zhong, Jinghai Chen, Wei Zhu, Jinliang Nan, Cheng Ni, Xinyang Hu   +15 more
wiley   +1 more source

Potentiality in Biology [PDF]

, 2018
We take the potentialities that are studied in the biological sciences (e.g., totipotency) to be an important subtype of biological dispositions. The goal of this paper is twofold: first, we want to provide a detailed understanding of what biological ...
A Bird, A Hüttemann, A Hüttemann, AC Love, B Alberts, CF Craver, CF Craver, CF Craver, CR Townsend, D Lewis, DH Mellor, E Prior, G Molnar, J Frydman, J Mackie, J McKitrick, J Woodward, KF Schaffner, L Darden, L Darden, M Kirschner, N Cartwright, NA Campbell, P Machamer, R Carnap, RN Brandon, RN Brandon, S Glennan, S Mumford, S Mumford, SC Stearns, SD Mitchell, SD Mitchell, SF Gilbert, SK Mills, T Handfield, W Bechtel, W Bechtel   +37 more
core   +1 more source

Inhibition of Macrophage ARID3A Alleviates Myocardial Ischemia‐Reperfusion Injury After Heart Transplantation by Reducing THBS1/CD47 Signaling‐Mediated Neutrophil Extracellular Traps Formation

Advanced Science, EarlyView.
This study reveals that ARID3A in macrophages can transcriptionally regulate the THBS1‐CD47 axis after heart transplantation (HT), thereby inducing activated neutrophils to release NETs through the p38 MAPK signaling pathway. The itaconate derivative 4‐OI can inhibit ARID3A in macrophages and promote the accumulation of antioxidant factors, thereby ...
Hao Tian, Yonghong Xiong, Junbiao Zhan, Zhikun Lu, Yuxi Zhang, Yan Leng, Qin Huang, Zhongyuan Xia   +7 more
wiley   +1 more source

Logistic Regression and Machine Learning Algorithms for the Risk Prediction of Perioperative Adverse Cardiovascular Events in Elderly Patients

AGING MEDICINE, EarlyView.
This manuscript focused on developing and validating prediction models for PACEs in elderly patients undergoing noncardiac surgery in China, utilizing routine laboratory examination findings. Logistic regression and machine learning algorithms were employed to construct these models.
Xiao Yan Li, Guang You Duan, Lin Li, Yi Yuan Gao, Li Wen Sun, Silin Zhu, Xiyezi Diao, Ning Wang, He Huang   +8 more
wiley   +1 more source

CLINICAL FEATURES AND DIAGNOSTIC ALGORITHMS OF CARDIOMYOPATHIES WITH RESTRICTIVE PHENOTYPE CAUSED BY CARDIAC TROPONIN I AND DESMIN GENES MUTATIONS

Педиатрическая фармакология, 2011
The authors are citing the literature data and share their own experiences of observation of two patients with cardiomyopathy associated with restrictive phenotype caused by mutations in defined genes encoding the synthesis of cardiac troponin I and ...
M.V. Tural'chuk, G.A. Novik, A.Ya. Gudkova   +2 more
doaj   +2 more sources

Dephosphorylation specificities of protein phosphatase for cardiac troponin I, troponin T, and sites within troponin T

International Journal of Biological Sciences, 2006
Protein dephosphorylation by protein phosphatase 1 (PP1), acting in concert with protein kinase C (PKC) and protein kinase A (PKA), is a pivotal regulatory mechanism of protein phosphorylation.
doaj