The major myosin-binding domain of skeletal muscle MyBP-C (C protein) resides in the COOH-terminal, immunoglobulin C2 motif. [PDF]
, 1993 A common feature shared by myosin-binding proteins from a wide variety of species is the presence of a variable number of related internal motifs homologous to either the Ig C2 or the fibronectin (Fn) type III repeats.
Fischman, DA +5 more
core
ESC Heart Failure, EarlyView.This state‐of‐the‐art review outlines a practical, evidence‐based framework for early acute heart failure management to address critical gaps in current guidance and improve early treatment outcomes. Key components include early identification of co‐existing conditions, bedside haemodynamic profiling, a structured diagnostic approach incorporating both
Anika S. Naidu +22 more
wiley +1 more source
Complexation and calcium-induced conformational changes in the cardiac troponin complex monitored by hydrogen/deuterium exchange and FT-ICR mass spectrometry [PDF]
, 2010 George M. Bou-Assaf +4 more
openalex +1 more source
Structure of the Regulatory Domain of Human Cardiac Troponin C in Complex with the Switch Region of Cardiac Troponin I and the Drug W7: The Basis of W7 as an Inhibitor of Cardiac Muscle Contraction [PDF]
, 2010 Marta Oleszczuk +3 more
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A Comparison of Patient History- and EKG-based Cardiac Risk Scores. [PDF]
, 2019 Patient-specific risk scores are used to identify individuals at elevated risk for cardiovascular disease. Typically, risk scores are based on patient habits and medical history - age, sex, race, smoking behavior, and prior vital signs and diagnoses.
Miller, Andrew C +2 more
core
The emerging role of Nrf2 in heart failure: From cardioprotection to therapeutic approaches
ESC Heart Failure, EarlyView.Nrf2 signalling is impaired in heart failure, contributing to oxidative stress, mitochondrial dysfunction, and ferroptosis, which drive neurohormonal activation, inflammation, and ischaemia‐reperfusion injury. This loss of Nrf2 activity exacerbates hypertension, diabetic cardiomyopathy, and cardiotoxicity, accelerating progression to overt heart ...
Emiliano Fiori +9 more
wiley +1 more source
Effect of Calcium-Sensitizing Mutations on Calcium Binding and Exchange with Troponin C in Increasingly Complex Biochemical Systems [PDF]
, 2010 Svetlana B. Tikunova +6 more
openalex +1 more source
ESC Heart Failure, EarlyView.Abstract In the 2021 European Society of Cardiology (ESC) heart failure (HF) guidelines, sodium–glucose cotransporter 2 (SGLT2) inhibitors were recommended for the prevention of HF in patients with type 2 diabetes mellitus (T2DM) and for the treatment of HF with reduced ejection fraction (HFrEF).
Marco Metra +25 more
wiley +1 more source
Cooperative binding of myosin subfragment-1 to the actin-troponin-tropomyosin complex.
, 1980 Lois E. Greene, E Eisenberg
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Calcium-Induced Conformational Changes in the Cardiac Isoform of the Troponin Complex Monitored By Hydrogen/deuterium Exchange and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry [PDF]
, 2010 George M. Bou-Assaf +4 more
openalex +1 more source