Results 211 to 220 of about 5,264,822 (290)

Expression and Purification of mutant troponin complex

Seibutsu Butsuri, 2000
K. Murakami, Y. Matsumura, K. Saeki, T. Yasunaga, T. Wakabayashi   +4 more
openaire   +2 more sources

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Association of high-sensitivity troponin with advanced fibrosis in metabolic dysfunction-associated steatotic liver disease and the potential mediating role of inflammation: A cross-sectional study of NHANES, 1999 to 2004. [PDF]

Medicine (Baltimore)
Li CY, Wu YX, Zhang Q, Wang K.
europepmc   +1 more source

Mitral regurgitation and decompensated heart failure in a young pregnant pony mare: An aetiological challenge

Equine Veterinary Education, Volume 38, Issue 10, Page e676-e685, October 2026.
Summary A 4‐year‐old, 6‐month pregnant, Welsh pony mare presented with severe acute clinical signs including depression, anorexia, pale mucous membranes, tachycardia with a grade 4/6 holosystolic murmur and moderate expiratory dyspnoea with diffuse wheezes. There was no evidence of placentitis or fetal distress.
M. F. David, L. Cannon, A. Tortereau, A. Thomas‐Cancian, I. Desjardins   +4 more
wiley   +1 more source

Handling persistent cardiac troponin elevation in asymptomatic athletes: The role of macrocomplexes. [PDF]

Am Heart J Plus
Wernhart S, Halle M, Zenk S.
europepmc   +1 more source

Annexin A4 Deficient Ventricular Myocytes Display Advanced Hypertrophy and Electrical Remodeling With Chronic β‐Adrenoceptor Stimulation

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Annexin A4 (A4) inhibits adenylyl cyclase 5 and may protect the heart during chronic β‐adrenergic stress. After 7 days of isoprenaline, A4‐deficient mice showed greater cardiomyocyte hypertrophy, prolonged action potentials, reduced Ito, preserved ICaL with altered activation, increased NCX1, and enhanced acute cAMP responsiveness compared with wild ...
Florentina Pluteanu, Alexander Heinick, Manuel Domnik‐Lehnert, Frank U. Müller, Christina Hermes   +4 more
wiley   +1 more source

Beyond sarcomere genetics: proteomic insights into hypertrophic cardiomyopathy. [PDF]

Biophys Rev
Gregorich ZR, Gao Z, Rossler KJ, Ralphe JC, Kamp TJ, Ge Y.   +5 more
europepmc   +1 more source

Development of a Multi‐Organ Microphysiological (MPS) Model to Study Age‐Related Comorbidities

Advanced Biology, Volume 10, Issue 9, September 2026.
This study developed a human‐based organ‐on‐a‐chip model for the comorbidity of sarcopenia and hypertrophic cardiomyopathy (HCM). The microphysiological system (MPS) co‐cultured skeletal muscle of sarcopenia pathology, cardiomyocytes of HCM pathology, and healthy hepatocytes in a circulated serum‐free common medium.
Gaurav Srivastava, Aakash Patel, Alice Rodriguez‐Fuguet, Akanksh Jambagi, Himanshi Jangir, Ahmad Nawaz, Afeef Mahmud, Camden Dwelle, Xiufang Guo, James Hickman   +9 more
wiley   +1 more source

Asymptomatic extreme troponin elevation preceding fatal clinically suspected sintilimab-associated myocarditis: a case report. [PDF]

Front Oncol
Zhao S, Song Z, Lu W, Chang L.
europepmc   +1 more source

Leonurine Ameliorates Doxorubicin‐Induced Cardiotoxicity via STING/NF‐κB/NLRP3 Inflammasome Signaling Pathway

Advanced Science, Volume 13, Issue 49, 3 September 2026.
ABSTRACT Doxorubicin‐induced cardiomyopathy (DIC) remains a dose‐limiting clinical challenge. This study reveals that cardiac vascular endothelial cells (CVECs) act as initial sensors of doxorubicin cardiotoxicity: circulating doxorubicin activates the cGAS‑STING pathway in CVECs, triggering NLRP3 inflammasome‑mediated pyroptosis and release of ...
Wang Jun, Chen Xiaoyang, Xu Jianglin, Yang Zhi, Tao Meijiao, He Jiale, Zhao Jiangfeng, Hei Xuanding, Xu Xuegong, Wang Wei, Li Chun   +10 more
wiley   +1 more source