Results 71 to 80 of about 6,673,815 (394)

Phosphorylation of troponin and the effects of interactions between the components of the complex [PDF]

Biochemical Journal, 1974
1. The troponin complex from skeletal muscle contains approximately 1 mol of phosphate/80000g of complex, covalently bound to the troponin T component. 2. On prolonged incubation of the troponin complex or troponin T with phosphorylase kinase the phosphate content of troponin T was increased to approx. 3mol/mol. 3. On prolonged incubation of troponin I
S. V. Perry, H. A. Cole
openaire   +4 more sources

Prognostically Significant Myocardial Injury in Patients Undergoing Transcatheter Aortic Valve Replacement

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Troponin elevation occurs commonly in the setting of transcatheter aortic valve replacement (TAVR). There is a lack of information on the extent of troponin elevation post TAVR that is prognostically significant. We assessed the optimal cutoff
Vikram Sharma, Tanujit Dey, Kesavan Sankaramangalam, Shehab A. R. Alansari, Louis Williams, Stephanie Mick, Amar Krishnaswamy, Lars G. Svensson, Samir Kapadia   +8 more
doaj   +1 more source

Physical limits on computation by assemblies of allosteric proteins [PDF]

, 2008
Assemblies of allosteric proteins, nano-scale Brownian computers, are the principle information processing devices in biology. The troponin C-troponin I (TnC-TnI) complex, the Ca$^{2+}$-sensitive regulatory switch of the heart, is a paradigm for Brownian computation.
arxiv   +1 more source

Troponin T3 regulates nuclear localization of the calcium channel Cavβ1a subunit in skeletal muscle [PDF]

, 2015
The voltage-gated calcium channel (Cav) β1a subunit (Cavβ1a) plays an important role in excitation-contraction coupling (ECC), a process in the myoplasm that leads to muscle-force generation. Recently, we discovered that the Cavβ1a subunit travels to the
Delbono, Osvaldo, Hereñú, Claudia Beatriz, Jiang, Yang, Messi, Maria Laura, Pereyra, Andrea Soledad, Taylor, Jackson, Wang, Zhong Min, Zhang, Tan   +7 more
core   +2 more sources

The Solution Structure of a Cardiac Troponin C−Troponin I−Troponin T Complex Shows a Somewhat Compact Troponin C Interacting with an Extended Troponin I−Troponin T Component [PDF]

Biochemistry, 2002
We have investigated the structure of the cTnC-cTnI-cTnT(198-298) calcium-saturated, ternary cardiac troponin complex by small-angle scattering with contrast variation. Shape restoration was also applied to the scattering information resulting from the deuterated cTnC subunit, the unlabeled cTnI-cTnT(198-298) subunits, and the entire complex.
Paul R. Rosevear, William T. Heller, Jill Trewhella, Natosha Finley, Ekram Abusamhadneh   +4 more
openaire   +3 more sources

Abnormal elevation of myocardial necrosis biomarkers after coronary artery bypass grafting without established myocardial infarction assessed by cardiac magnetic resonance

Journal of Cardiothoracic Surgery, 2017
Background The diagnosis of peri-procedural myocardial infarction is complex, especially after the emergence of high-sensitivity markers of myocardial necrosis. Methods In this study, patients with normal baseline cardiac biomarkers and formal indication
Fernando Teiichi Costa Oikawa, Whady Hueb, Cesar Higa Nomura, Alexandre Ciappina Hueb, Alexandre Volney Villa, Leandro Menezes Alves da Costa, Rodrigo Morel Vieira de Melo, Paulo Cury Rezende, Carlos Alexandre Wainrober Segre, Cibele Larrosa Garzillo, Eduardo Gomes Lima, Jose Antonio Franchini Ramires, Roberto Kalil Filho   +12 more
doaj   +1 more source

Risk markers by sex for in-hospital mortality in patients with acute coronary syndrome: a machine learning approach [PDF]

arXiv, 2021
Background: Several studies have highlighted the importance of considering sex differences in the diagnosis and treatment of Acute Coronary Syndrome (ACS). However, the identification of sex-specific risk markers in ACS sub-populations has been scarcely studied.
arxiv  

Recombinant nanobodies detecting the human cardiac troponin proteins by ELISA [PDF]

, 2023
We tested the capacity of antibodies RB733, RB734, RB766, RB767, RB768, RB769, RB770, RB771, RB772 and RB773 to recognize by ELISA three different molecular forms of the human cardiac troponin T isoform 6 (cTnT): an N-terminal peptide (Nter-cTnT), the ...
Bollen Pinto, Bernardo, Hammel, Philippe, Hartley, Oliver, Paolini Bertrand, Marianne, Vuilleumier, Nicolas, Walder, Bernhard   +5 more
core   +1 more source

The value of troponin assays in modern medical practice [PDF]

, 2016
Cardiac troponins – C, I and T – form part of the troponin complex which is involved in the regulation of the calcium-mediated interaction of actin and myosin in myocytes. Each troponin has a different role in the above mentioned complex.
Cutajar, Karl
core  

Universal Proteomic Signature After Exercise‐Induced Muscle Injury in Muscular Dystrophies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Several neuromuscular disorders (NMDs) are characterized by progressive muscle damage and are marked by the elevation of circulating muscle proteins from activity‐related injury. Despite a diverse array of genetic drivers, many NMDs share similar patterns of exercise intolerance and higher concentrations of muscle injury proteins ...
Mads G. Stemmerik, Benjamin Barthel, Nanna R. Andersen, Sofie V. Skriver, Alan J. Russell, John Vissing   +5 more
wiley   +1 more source