Tacrolimus trough level and oxidative stress in Tunisian kidney transplanted patients [PDF]
Renal FailureBackground The effect of tacrolimus (TAC) on oxidative stress after kidney transplantation (KT) is unclear. This study aimed to evaluate the influence of TAC trough levels of oxidative stress status in Tunisian KT patients during the post-transplantation
Mariam Ammar +7 more
doaj +2 more sources
Changes in imatinib plasma trough level during long-term treatment in patients with intermediate- or high-risk gastrointestinal stromal tumors: Relationship between covariates and imatinib plasma trough level [PDF]
Frontiers in Surgery, 2023 BackgroundImatinib is the first-line adjuvant treatment for gastrointestinal stromal tumors (GISTs). Considering that some studies have suggested that imatinib (IM) plasma trough levels (Cmin) change with time, the aim of this study is to assess the ...
Xingye Wu +4 more
doaj +2 more sources
Vancomycin trough level and loading dose [PDF]
Infection and Drug Resistance, 2018 Felipe Francisco Tuon,1 Rudson Romero,2 Juliano Gasparetto,2 Juliette Cieslinski1 1Laboratory of Microbiology and Emerging Infectious Diseases, Pontifícia Universidade Católica do Paraná, Curitiba, Paraná, Brazil; 2School of ...
Tuon FF +3 more
doaj +2 more sources
Impact of IVIG vs. SCIG on IgG trough level and infection incidence in primary immunodeficiency diseases: A systematic review and meta-analysis of clinical studies [PDF]
World Allergy Organization Journal, 2019 Background: Monthly intravenous immunoglobulin (IVIG) and weekly subcutaneous immunoglobulin (SCIG) have been regarded as therapeutically equivalent treatments for primary immunodeficiency diseases (PIDD). Immunoglobulin G (IgG) trough level is used as a
Pragya Shrestha +4 more
doaj +2 more sources
Smartphone-measured tremor and tacrolimus trough levels in kidney transplant recipients: an exploratory prospective study [PDF]
Frontiers in TransplantationTacrolimus commonly causes tremor as a side effect, although the relationship between tremor and tacrolimus drug levels is not well established. This work presents the development of a smartphone-based tremor assessment to explore whether tremor features
Annudesh Liyanage +15 more
doaj +2 more sources
Biomedicines, 2023 Osimertinib is a standard treatment for patients with EGFR-mutated non-small cell lung carcinoma (NSCLC). We evaluated the relationship between plasma osimertinib concentrations and treatment outcome in patients with NSCLC for this cohort study.
Tatsuro Fukuhara +12 more
doaj +1 more source
Evaluation of the Association between Trough and Area Under the Curve to Minimum Inhibitory Concentration Ratio (AUC24/MIC) of Vancomycin in Infected Patients with Methicillin Resistant Staphylococcus aureus (MRSA) [PDF]
Pharmaceutical Sciences, 2021 Background: The recent studies emphasized on the correlation of vancomycin antibacterial effect with pharmacokinetics properties such as the area under the curve/minimum inhibitory concentration (AUC24/MIC) ≥400 and serum trough level 15-20 mg /L in the ...
Ayda Esmaeili +5 more
doaj +1 more source
Pharmaceutics, 2023 There are limited data on therapeutic drug monitoring (TDM) in inflammatory bowel disease (IBD) patients treated with vedolizumab (VDZ). Although an exposure–response relation has been demonstrated in the post-induction phase, this relationship is more ...
Merve Sivridaş +9 more
doaj +1 more source
Pharmaceuticals, 2021 Small molecule kinase inhibitors (SMKIs) are widely used in oncology. Therapeutic drug monitoring (TDM) for SMKIs could reduce underexposure or overexposure.
Ruben A. G. van Eerden +4 more
doaj +1 more source
Proactive versus Reactive Therapeutic Drug Monitoring: Why, When, and How?
Inflammatory Intestinal Diseases, 2021 Background: Up to a third of inflammatory bowel disease) patients show primary nonresponse to antitumor necrosis factor (anti-TNF) biological therapy, and of those who respond, up to 40% develop secondary loss of response (LOR).
Manar Shmais +2 more
doaj +1 more source