Results 41 to 50 of about 8,959,692 (295)

Practical approaches to improve vancomycin-related patient outcomes in pediatrics- an alternative strategy when AUC/MIC is not feasible

BMC Pharmacology and Toxicology, 2022
Background Anecdotal experience and studies have shown that most pediatric patients fail to reach target therapeutic vancomycin trough levels (VTLs) and required higher total daily doses (TDD).
Kashif Hussain, Muhammad Sohail Salat, Shahzad Rauf, Manoj Rathi, Midhat Khan, Fizzah Naz, Wasif Ahmed Khan, Rahila Ikram, Gul Ambreen   +8 more
doaj   +1 more source

Assessment of serum flecainide trough levels in patients with tachyarrhythmia

Journal of Pharmacy and Pharmacology, 2005
Abstract The reported therapeutic range for trough flecainide concentration is 200–1000 ng mL−1. Severe adverse events, such as ventricular arrhythmias, have occurred occasionally in patients whose serum flecainide exceeded 1000 ng mL−1. However, the lower limit remains controversial.
Masato, Homma, Keisuke, Kuga, Kosuke, Doki, Kumi, Katori, Iwao, Yamaguchi, Kenji, Sugibayashi, Yukinao, Kohda   +6 more
openaire   +2 more sources

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Laboratory Tests in Inflammatory Bowel Disease: An Evidence-Based Approach to Daily Practice

Biomedicines
Inflammatory bowel diseases (IBDs) comprise a group of chronic gastrointestinal disorders characterized by periods of relapse and remission. The mainstay of treatment is medical, involving medications such as steroids, immune modulators, monoclonal ...
Katelin Durham, Tyler Atagozli, David E. Elliott, M. Nedim Ince   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Therapeutic drug monitoring of daptomycin in a critically ill patient cohort

Frontiers in Medicine
BackgroundPharmacokinetics of antimicrobial agents are altered in critically ill patients. Therefore, therapeutic drug monitoring (TDM) has gained much attention in recent years.
Rubi Stephani Hellwege, Mattia Müller, Rolf Erlebach, Onur Sazpinar, Alix Buhlmann, Reto A. Schuepbach, Sascha David, Sascha David, Daniel A. Hofmaenner   +8 more
doaj   +1 more source

Analysis of synoptic situation and environmental parameters of thunderstorm gales in Hainan

暴雨灾害, 2022
In this study we analyzed the intensity, temporal and spatial distribution, circulation situation and environmental parameters of thunderstorm gale during 2014-2018 in Hainan using regional encrypted automatic station data and sounding data at Haikou ...
Yuanhui KE, Mingming MA, Yan ZHENG, Wen FENG   +3 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Navigating Vancomycin and Acute Kidney Injury: AUC- vs. Trough-Guided Monitoring in Initial and Steady-State Therapy

Antibiotics
Background/Objectives: Vancomycin, a glycopeptide antibiotic used for gram-positive infections, is associated with acute kidney injury (AKI). Therapeutic drug monitoring (TDM) is recommended to minimize this risk while ensuring therapeutic efficacy. This
Astrid Marovič, Tomaž Vovk, Maja Petre
doaj   +1 more source

Plasma apixaban levels in Chinese patients with chronic kidney disease—Relationship with renal function and bleeding complications

Frontiers in Pharmacology, 2022
Introduction: Accumulation of apixaban in plasma is a major concern in patients with chronic kidney disease (CKD). Studies that investigated plasma apixaban level in CKD patients and its association with clinically significant events are scarce.Methods ...
Chun-fung Sin, Ka-ping Wong, Ka-ping Wong, Tsz-fu Wong, Chung-wah Siu, Desmond Y. H. Yap   +5 more
doaj   +1 more source