Results 51 to 60 of about 8,959,692 (295)
Serial trough and peak amikacin levels in plasma as predictors of nephrotoxicity [PDF]
Antimicrobial Agents and Chemotherapy, 1989 We studied 113 patients treated with intravenous amikacin to determine the value of determining serial trough and peak amikacin levels in plasma for predicting nephrotoxicity. Thirteen patients (11.5%) developed renal toxicity, with significant increases from 48 to 96 h in both peak and trough amikacin levels (6.7 +/- 4.7 [standard deviation] days ...
A M, Contreras +9 more
openaire +2 more sources
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Frontiers in PediatricsBackgroundLiterature on the association between high infliximab (IFX) trough levels and perianal fistula response in pediatric patients with perianal fistulizing Crohn's disease (PFCD) is limited.
Joonhyuk Son +9 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Comparative System Analysis of Parabolic Trough Power Plants with DSG and Oil using Integrated Thermal Energy Storage [PDF]
, 2011 In addition to the commercial parabolic trough power plants using synthetic oil, the direct steam generation (DSG) is one option for future trough plants.
Laing, Doerte +6 more
core
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Heat Loss Measurements on Parabolic Trough Receivers [PDF]
, 2010 A measurement set-up to determine the heat losses of single parabolic trough receiver components at steady state conditions has been developed at Schott.
Pernpeintner, Johannes +8 more
core
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
SOLAR TROUGH MIRROR SHAPE SPECIFICATIONS [PDF]
, 2009 The performance of concentrating solar collectors depends to a significant amount on the shape accuracy of the mirrors reflecting the sunlight onto the absorber.
Lüpfert, Eckhard, Ulmer, Steffen
core
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source