Results 251 to 260 of about 8,959,692 (295)

Comparison of trough concentration and area under the curve of vancomycin associated with the incidence of nephrotoxicity and predictors of a high trough level

Journal of Infection and Chemotherapy, 2021
A high vancomycin trough concentration during therapy is associated with increased nephrotoxicity, and the recent guidelines for therapeutic monitoring of vancomycin recommend target of the ratio of area under the curve (AUC) to minimum inhibitory concentration.
Ayako Suzuki, Yukihiro Hamada, Hirokazu Ikeda   +2 more
exaly   +3 more sources

Sirolimus for the treatment of kaposiform hemangioendothelioma: In a trough level‐dependent way

The Journal of Dermatology, 2021
AbstractWith the accumulation of clinical practice, sirolimus is now widely viewed as an effective agent in kaposiform hemangioendothelioma (KHE) treatment using a dose based on experience. Therefore, this retrospective research aimed to provide evidence‐based suggestions on the most appropriate dose and trough level of sirolimus.
Yuhua Shan, Ruicheng Tian, Honxiang Gao, Lei Zhang, Jingjing Li, Chenjie Xie, Yu Liang, Yiwei Chen, Jing Wang, Min Xu, Song Gu   +10 more
openaire   +2 more sources

Monitoring changes in cyclosporine dosage by trough level testing

Clinical Transplantation, 1995
The concept of a narrow therapeutic window has guided the management of transplant recipients on cyclosporine immunosuppression since its inception more than a decade ago. The need to maintain immunosuppression and avoid toxicity imposed the requirement of monitoring cyclosporine levels within a limited range.
M, Takasugi, J K, Takasugi, L, Barba
openaire   +2 more sources

Cyclosporin trough levels: is monitoring necessary during short-term treatment in psoriasis? A systematic review and clinical data on trough levels

British Journal of Dermatology, 2002
Cyclosporin is an effective treatment for severe plaque psoriasis. Unfortunately, its use may be limited by time- and dose-related nephrotoxicity. Serum trough levels may be useful for monitoring the risk of nephrotoxicity.To determine whether monitoring of trough levels is necessary in psoriasis patients undergoing short-term treatment with ...
V M R, Heydendael, P I, Spuls, I J M, Ten Berge, B C, Opmeer, J D, Bos, M A, de Rie   +5 more
openaire   +3 more sources

Failure of Traditional Trough Levels to Predict Tacrolimus Concentrations

Therapeutic Drug Monitoring, 2001
The objective of this study was to estimate tacrolimus population parameter values and to evaluate the ability of the maximum a posteriori probability (MAP) Bayesian fitting procedure to predict tacrolimus blood levels, using the traditional strategy of monitoring only trough levels, for dosage individualization in liver transplant patients.
M, Macchi-Andanson, B, Charpiat, R W, Jelliffe, C, Ducerf, N, Fourcade, J, Baulieux   +5 more
openaire   +2 more sources

Predicting the response to infliximab from trough serum levels

Gut, 2009
Optimal use of a drug implies the correct dosage, with the lowest level just before the periodically administered medicine is taken (trough level) being sufficiently high to exert the full effect of the drug. On the other hand, peak levels and average levels should not exceed concentrations which are associated with increased toxicity.
Paul, Rutgeerts, Severine, Vermeire, Gert, Van Assche   +2 more
openaire   +2 more sources

Serum levels of gentamicin at peak and trough in neonates and infants

The Indian Journal of Pediatrics, 1991
The peak and the trough levels of serum gentamicin were determined in 50 cases of neonates and infants by microbiological assay method. The peak levels in the neonates and the infants were 5.98 +/- 0.48 and 4.63 +/- 0.31 mcg/ml respectively. The trough levels in the corresponding group were 1.06 +/- 0.19 and 0.94 +/- 0.23 mcg/ml. The mean values of the
M, Shahidullah, M Q, Talukder, A K, Chowdhury, S, Ali, A, Rashid   +4 more
openaire   +2 more sources

Bactericidal effect of gentamicin trough concentration provides a rationale for administration of bolus doses and maintenance of trough levels

Journal of Antimicrobial Chemotherapy, 1994
An in-vitro study was made of the influence of trough gentamicin concentrations (Cmin) on the bactericidal effect of gentamicin against Escherichia coli NCTC 10418. Lag phase bacterial cells were exposed in vitro to gentamicin concentration versus time profiles which modelled profiles in patients up to 30 min after either an 80 mg iv bolus over 1 min ...
A J, McLean, E B, Bastone, L L, Ioannides-Demos, W J, Spicer   +3 more
openaire   +2 more sources

Clinical relevance of deferasirox trough levels in β‐thalassemia patients

Clinical and Experimental Pharmacology and Physiology, 2017
SummaryWe evaluated the role of deferasirox therapeutic drug monitoring in order to avoid toxicity or treatment failure. Plasma concentrations, measured between two consecutive liver iron determinations, were determined at the end of dosing interval. Fifty‐four β‐thalassemic adult patients were enrolled: 50% were males; median age was 32.3 years (IQR ...
Allegra, Sarah, Massano, Davide, De Francia, Silvia, Longo, Filomena, Piccione, Francesca, Pirro, Elisa, Cusato, Jessica, D'Avolio, Antonio, Piga, Antonio   +8 more
openaire   +3 more sources

Monitoring trough levels in cyclosporine for atopic dermatitis: A systematic review

Pediatric Dermatology, 2019
AbstractBackgroundCyclosporine is a useful immunosuppressive agent for achieving disease control in moderate to severe atopic dermatitis in children and adults. However, it carries the potential for nephrotoxicity. Monitoring of drug levels is performed in other patient groups, such as transplant recipients, but is not commonplace in the management of ...
Stephanie C. Blake, Dedee F. Murrell
openaire   +2 more sources