Results 161 to 170 of about 173,869 (207)
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2014
Hearing is a particularly sensitive form of mechanosensation that relies on dedicated ion channels transducing sound-induced vibrations that hardly exceed Brownian motion. Attempts to molecularly identify these auditory transduction channels have put the focus on TRPs in ears.
Damiano, Zanini, Martin C, Göpfert
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Hearing is a particularly sensitive form of mechanosensation that relies on dedicated ion channels transducing sound-induced vibrations that hardly exceed Brownian motion. Attempts to molecularly identify these auditory transduction channels have put the focus on TRPs in ears.
Damiano, Zanini, Martin C, Göpfert
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2012
The Transient receptor potential (TRP) family of cation channels is a large protein family, which is mainly structurally uniform. Proteins consist typically of six transmembrane domains and mostly four subunits are necessary to form a functional channel.
Rudi, Vennekens +2 more
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The Transient receptor potential (TRP) family of cation channels is a large protein family, which is mainly structurally uniform. Proteins consist typically of six transmembrane domains and mostly four subunits are necessary to form a functional channel.
Rudi, Vennekens +2 more
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Seminars in Immunopathology, 2015
Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cerebral cortex, where pain is finally
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Nociception is the process of transmission of painful signals by nociceptors in the primary afferent nerve fibers, which specifically respond to noxious stimuli. These noxious stimuli are detected by nociceptors and converted into electrical signals, which are then transmitted to the spinal cord, thalamus, and the cerebral cortex, where pain is finally
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Interaction of the trp repressor and RNA polymerase with the trp operon
Journal of Molecular Biology, 1975Abstract An in vitro transcription system for the tryptophan operon of Escherichia coli was used to determine the mechanism by which trp † repressor inhibits transcription of the operon. It was found that trp repressor-binding prevents binding of RNA polymerase to the operon. It was also observed that when polymerase is prebound to the trp promoter,
C L, Squires, F D, Lee, C, Yanofsky
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Interaction of the trp repressor with trp operator DNA fragments
European Biophysics Journal, 1993The interaction of the trp repressor with several trp operator DNA fragments has been examined by DNA gel retardation assays and by circular dichroism, in the absence and presence of the corepressor L-tryptophan. The holorepressor binds stoichiometrically to both the trpO and aroH operators, forming 1:1 complexes.
P, Beckmann, S R, Martin, A N, Lane
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Direct recognition of the trp operator by the trp holorepressor — a review
Gene, 1994Two different X-ray co-crystal structures of the Escherichia coli trp holorepressor complexed with DNA suggest that the TrpR protein recognizes specific DNA sequences primarily with a network of water-mediated H-bonds. However, the more recent nuclear magnetic resonance (NMR) solution structures of the holorepressor-operator complex show no long-lived,
P, Youderian, D N, Arvidson
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2014
The Drosophila "transient receptor potential" channel is the prototypical TRP channel, belonging to and defining the TRPC subfamily. Together with a second TRPC channel, trp-like (TRPL), TRP mediates the transducer current in the fly's photoreceptors. TRP and TRPL are also implicated in olfaction and Malpighian tubule function.
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The Drosophila "transient receptor potential" channel is the prototypical TRP channel, belonging to and defining the TRPC subfamily. Together with a second TRPC channel, trp-like (TRPL), TRP mediates the transducer current in the fly's photoreceptors. TRP and TRPL are also implicated in olfaction and Malpighian tubule function.
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2014
The mammalian olfactory system has become an excellent model system to understand the function of transient receptor potential (TRP) channels within their native cellular and circuit environment. The discovery that the canonical TRP channel TRPC2 is highly expressed in sensory neurons of the vomeronasal organ (VNO) has led to major advances in our ...
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The mammalian olfactory system has become an excellent model system to understand the function of transient receptor potential (TRP) channels within their native cellular and circuit environment. The discovery that the canonical TRP channel TRPC2 is highly expressed in sensory neurons of the vomeronasal organ (VNO) has led to major advances in our ...
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Current Pharmaceutical Design, 2009
Preclinical research has identified an array of ion channels in sensory neurons involved in the generation and transduction of pain as potential targets for pharmacological intervention. Paramount among these new targets is the family of thermosensitive transient receptor potential channels, referred to as "thermoTRPs".
Daniel N, Cortright, Arpad, Szallasi
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Preclinical research has identified an array of ion channels in sensory neurons involved in the generation and transduction of pain as potential targets for pharmacological intervention. Paramount among these new targets is the family of thermosensitive transient receptor potential channels, referred to as "thermoTRPs".
Daniel N, Cortright, Arpad, Szallasi
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Comprehensive Physiology, 2012
Abstract TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential ( trp ) locus in Drosophila .
Maarten, Gees +3 more
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Abstract TRP channels constitute a large superfamily of cation channel forming proteins, all related to the gene product of the transient receptor potential ( trp ) locus in Drosophila .
Maarten, Gees +3 more
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