Results 141 to 150 of about 176,809 (302)

Biokatalysatoren für die Geranylierung von Peptiden mit Linearen und Zyklischen Prenylgruppen

Angewandte Chemie, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids ...
Sarolt Magyari, Leon F. Schwarz, Luca Schlautmann, Kai Schließmann, Christopher Slotman, Nina von Felten, Claus‐Michael Lehr, Rolf Müller, Alexander F. Kiefer, Jörn Piel, Florian Hubrich   +10 more
wiley   +1 more source

Prenatal Poly I:C exposure affects tryptophan-kynurenine metabolism associated with intestinal microbiome in female juvenile rats

Frontiers in Immunology
BackgroundEmerging evidence suggests that disrupted tryptophan (TRP) metabolism may contribute to an increased risk of neurodevelopmental disorders (NDDs) in the context of maternal inflammation, with gut microbiota playing a pivotal role in regulating ...
Lirong Yang, Lirong Yang, Huiyu Chen, Huiyu Chen, Menglu Zeng, Menglu Zeng, Yanfang Lu, Yanfang Lu, Chen Xu, Chen Xu, Zhenju Cao, Zhenju Cao, Fuchun Zhong, Fuchun Zhong, Xinyu Yang, Xinyu Yang, Anying Shen, Anying Shen, Yueqing Su, Yueqing Su, Yueqing Su, Chao Deng, Hua Cao, Hua Cao, Hua Cao   +24 more
doaj   +1 more source

Analyzing the Tourism Risk Perception (TRP) of Bangladesh [PDF]

Tourism Risk Perception (TRP) is a crucial factor that shapes the overall experience and satisfaction of visitors to a particular destination. The overall objective of this study was to analyze the TRP of Bangladesh.
Islam, Mohibul, Islam, Muttakin, Ahmed, Ahsanul, Hasan, Mir Md Mehedi, Sardar, Sazu, Sobhan, Sanjana, Islam, Md. Mazharul   +6 more
core   +1 more source

Pharmaceutical composition comprising trp-1 and trp-2 genes or proteins for the prevention or treatment of gait abnormality associated disease

, 2020
본 발명은 trp-1 및 trp-2 유전자 또는 상기 유전자로부터 코딩되는 단백질을 포함하는 보행이상 관련 증후군 예방 또는 치료용 약학적 조성물에 관한 것이며, 또한 상기 trp-1 또는 trp-2의 돌연변이 유전자 또는 이의 단백질을 보행이상 관련 증후군의 진단 마커로의 용도에 관한 것이다.
연지혜, 김규형, 김진만
core  

Magnetic interactions in copper model systems Cu2+:Gly-Trp and Cu2+: Trp-Gly

, 1997
Derivados metálicos de aminoácidos são sistemas modelo simples para o estudo de íons metálicos em estruturas que simulam proteínas. O principal objetivo dessas investigações é avaliar as magnitudes dos parâmetros de acoplamento por interação de troca e ...
Costa Filho, Antonio José da, Antonio José da Costa Filho   +1 more
core  

Assessment of pneumonitis in patients with lung cancer undergoing radioimmunotherapy and immune checkpoint inhibitor rechallenge

Communications Medicine
Background: The combination of immune checkpoint inhibitors (ICIs) with radiotherapy (RT) has improved survival in patients with advanced lung cancer, yet treatment-related pneumonitis (TRP) is highly toxic.
Yingchen Ruan, Minjie Ruan, Zhishen Fang, Zhihua Sun, Kuimao Zhuang, Zenan Wu, Chuanyun Yu, Zhaoguo Liu, Dehua Wu, Zhongyi Dong, Wei Wei   +10 more
doaj   +1 more source

Atroposelective Access to Bicyclic Peptides via an Amide Photocaging Strategy

Angewandte Chemie International Edition, EarlyView.
Ansamers are an atypical class of atropisomers (Pansa/Mansa) and stereoselective synthesis of its two conformational isomers is challenging. We introduce a photocaged amide protection strategy: photolabile groups in monocycles reversibly modulate amide geometry, biasing macrolactamization to selectively give Pansa or Mansa.
Haijian Yang, Joseph De Luna, Hui Pan, Jiyong Park, Wu Su, Mu‐Hyun Baik, Roderich D. Süssmuth, Guiyang Yao   +7 more
wiley   +1 more source

Biocatalysts for Peptide Geranylation With Linear and Cyclic Prenyl Groups

Angewandte Chemie International Edition, EarlyView.
A combination of genome mining, synthetic biology, and biocatalytic assays revealed enzymes that install linear and cyclized prenyl moieties on ribosomally or chemically synthesized peptides. The promiscuity of both enzymes, while being specific for modification of C‐terminal tryptophans, enables enzymatic access to peptide terpenoid hybrids.
Sarolt Magyari, Leon F. Schwarz, Luca Schlautmann, Kai Schließmann, Christopher Slotman, Nina von Felten, Claus‐Michael Lehr, Rolf Müller, Alexander F. Kiefer, Jörn Piel, Florian Hubrich   +10 more
wiley   +1 more source

Peak Serum Vancomycin Levels Are Achieved Between 6 and 24 Hours After Implantation of Vancomycin‐Soaked Anterior Cruciate Ligament Grafts

Arthroscopy, EarlyView.
Purpose To examine systemic exposure and elution characteristics of liquid vancomycin‐soaked anterior cruciate ligament (ACL) grafts in vivo by assessing serum vancomycin levels over 48 hours after ACL reconstruction and comparing the resulting concentrations with the toxic threshold of 15 to 20 μg/mL.
Swen Witteveen, Steffen T. Ubl, Sophia Krombholz, Daniel Guenther, Carolin Flieser, Arasch Wafaisade, Bertil Bouillon, Mario Thevis, Thomas R. Pfeiffer   +8 more
wiley   +1 more source

Enhancing Meat Quality Through Dietary Fiber: Insights Into the Gut Microbiota‐Derived Short‐Chain Fatty Acids‐Muscle Axis

Animal Research and One Health, EarlyView.
Dietary fiber (DF) modulates meat quality through the gut‐muscle axis by reshaping gut microbiota, improving intestinal integrity, reducing inflammation, and regulating muscle metabolism. These mechanisms influence muscle fiber characteristics and post‐mortem biochemistry, thereby enhancing tenderness, juiciness, color, flavor, and nutritional value of
Zeshan Zulfiqar, Muhammad Arslan Asif, Layla Al‐Mitib, Nabeela Ashiq, Haojie Wang, Yalei Cui, Boshuai Liu, Shucheng Huang, Yinghua Shi   +8 more
wiley   +1 more source