Results 131 to 140 of about 176,809 (302)
Activation of recombinant trp by thapsigargin in Sf9 insect cells
, 1994 The mammalian protein responsible for Ca2+ release-activated current (Icrac) may be homologous to the Drosophila protein designated trp. Thus the activity of trp, and another Drosophila protein designated trp-like or trpl, may be linked to depletion of ...
W. G. Sinkins +4 more
core +1 more source
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 This review attempts to provide an overview of the current knowledge of TRP proteins and their possible role in bladder function and disease. At present, there are 28 transient receptor potential (TRP) channels (subdivided into 7 categories or families) which are involved in a number of functions [G.A.
openaire +3 more sources
, 2013 Users can represent the TRP channel PPI data as a network using the Cytoscape program. (A) The PPI network consists of the relations between TRP channels and their interacting proteins.
Soo-Yong Shin (303252) +8 more
core +1 more source
Angewandte Chemie, EarlyView.Strategic incorporation of unnatural amino acids transforms macrocyclic peptides into drug‐like molecules capable of engaging challenging targets. These building blocks enhance stability, permeability, and bioavailability, accelerating the development of next‐generation peptide therapeutics.
Krishna K. Sharma +5 more
wiley +1 more source
Tryptophan As a New Member of RNA‐Induced Silencing Complexes Prevents Colon Cancer Liver Metastasis
Advanced ScienceEssential amino acids (EAA) and microRNAs (miRs) control biological activity of a cell. Whether EAA regulates the activity of miR has never been demonstrated. Here, as proof‐of‐concept, a tryptophan (Trp, an EAA) complex containing Argonaute 2 (Ago2) and
Fangyi Xu +11 more
doaj +1 more source
Transient receptor potential (TRP) channels: a metabolic TR(i)P to obesity prevention and therapy
, 2018 Cellular transport of ions, especially by ion channels, regulates physiological function. The transient receptor potential (TRP) channels, with 30 identified so far, are cation channels with high calcium permeability.
Bishnoi, M. +15 more
core +1 more source
Atroposelektiver Zugang zu Bizyklischen Peptiden Durch Eine Amid‐Photocaging‐Strategie
Angewandte Chemie, EarlyView.Ansamere sind eine atypische Klasse von Atropisomeren (Pansa/Mansa) deren stereoselektive Synthese ihrer beiden Konformationsisomere anspruchsvoll ist. Wir stellen eine Strategie mit photogeschützten Amiden vor: Photolabile Gruppen in Monozyklen modulieren reversibel die Amidgeometrie und lenken die Macrolaktamisierung selektiv zu Pansa oder Mansa ...
Haijian Yang +7 more
wiley +1 more source
Angewandte Chemie, EarlyView.Sun et al. proposed an axial boron coordination strategy to reconstruct the stereostructure of Cu SAzymes and enable them to serve as efficient laccase mimics for high‐throughput smart sensor array detection of phenolic pollutants in water phases. ABSTRACT Developing single‐atom nanozymes with stereoconfigurations is a new paradigm for biomimetic ...
Qijun Sun +8 more
wiley +1 more source
Ac-D-Trp-PheNH2 AND Ac-D-Trp-Phe-GlyNH2 - A NEW CLASS OF UNUSUAL OPIOID PEPTIDES
, 2010 In the last few years we discovered and investigated novel cyclic opioid peptides, c[Tyr-Xaa-D-Trp- Phe-Yaa], based on the sequence of EM-1. These peptides, deprived of a protonable amino group, bind and activate the MOR receptor mainly through the ...
SPAMPINATO, SANTI MARIO +5 more
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Angewandte Chemie, EarlyView.A meso‐carboxamide‐substituted BODIPY fluorescent probe reports myeloperoxidase (MPO) activity via electrophilic chlorination by MPO‐derived HOCl, generating a highly emissive chlorinated product with a ca. 40 nm bathochromic shift. Applications in quantitative MPO assays, cellular imaging of MPO‐derived HOCl, redox‐dependent discrimination of cancer ...
Siyoung Cho +3 more
wiley +1 more source