Results 111 to 120 of about 164,112 (301)

Task optimized vision transformer for diabetic retinopathy detection and classification in resource constrained early diagnosis settings

Scientific Reports
Diabetic Retinopathy (DR) is a progressive complication of diabetes and a leading cause of preventable blindness worldwide. Early detection and accurate classification of DR severity are critical for timely intervention but remain challenging ...
Ramasubramanian Bhoopalan, Priyadharshini Sekar, N. Nagaprasad, Tadesse Regassa Mamo, Ramaswamy Krishnaraj   +4 more
doaj   +1 more source

A moderate inflammation caused by the deterioration of housing conditions modifies Trp metabolism but not Trp requirement for growth of post-weaned piglets

Animal, 2010
Deterioration of the environment in which piglets are housed after weaning induces a moderate inflammatory response and modifies tryptophan (Trp) metabolism that can, in turn, decrease Trp availability for growth.
N. Le Floc’h, J.J. Matte, D. Melchior, J. van Milgen, B. Sève   +4 more
doaj   +1 more source

TRP channels and pruritus [PDF]

, 2013
Itch (pruritus) is one of the most often seen sensory phenomena in clinical practice. Recent neurophysiological findings proposed the existence of a novel pruriceptive system which includes a multitude of pruritogenic (itch-inducing) peripheral mediators,
Tóth, Balázs István, Bíró, Tamás
core   +1 more source

De Novo Designed Minibinders Targeting the GDF15–GFRAL Axis Reverse Cancer Cachexia and Restore Anti‐Tumor Immunity

Advanced Science, EarlyView.
Tumor‐derived GDF15 drives cancer cachexia and suppresses antitumor immunity. Here, de novo designed minibinders targeting the GDF15–GFRAL interface achieve picomolar affinity and potent pathway blockade. The minibinders alleviate cachexia, restore CD8+ T‐cell infiltration, enhance anti–PD‐1 responsiveness, and provide survival benefits across tumor ...
Haitao Wang, Tianzhen Hua, Meiling Wang, Bingbing Meng, Yue Zhang, Chengxu Jiang, Yunhe Gao, Hongqi Yang, Jian Bo   +8 more
wiley   +1 more source

Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance

Arthritis Research & Therapy
Background Immune imbalance caused by imbalanced helper T(Th)17/regulatory T (Treg) and follicular helper T (Tfh)/follicular regulatory T (Tfr) cells drives the onset of rheumatoid arthritis (RA) fundamentally.
Ruihe Wu, Baochen Li, Rui Su, Xiaoyang Liu, Anqi Gao, Jing Luo, Chong Gao, Xiaofeng Li, Caihong Wang   +8 more
doaj   +1 more source

Sulfoxide-mediated Cys-Trp-selective bioconjugation that enables protein labeling and peptide heterodimerization [PDF]

A method was developed that enables the magnesium chloride (MgCl2)-activated S-acetamidomethyl cysteine sulfoxide (Cys(Acm)(O)) to induce the sp2(C−H) sulfenylation of the indole ring of Trp residues.
Kota, Hidaka, Harunori, Yoshikawa, Kento, Ohkawachi, Hidetaka, Kosako, Akira, Otaka, Wataru, Nomura, Kohei, Nishino, Tetsuro, Yoshimaru, Daishiro, Kobayashi, Junya, Hayashi, Kiyomi, Nigorikawa, Masaya, Deda, Yutaka, Kohmura, Naozumi, Ishimaru, Toyomasa, Katagiri, Takaaki, Tsunematsu   +15 more
core   +1 more source

Englerin A selectivity against TRP family and non-TRP family ion channels. [PDF]

, 2015
Englerin A selectivity against TRP family and non-TRP family ion channels.
Lei Xu (78676), Haisong Ju (758895), Jianmin Lao (758887), Giuliano Berellini (758901), Gül Erdemli (758904), Philipp Krastel (308339), Nathan T. Ross (758902), Adam Amaral (758891), Emily Thomas (758885), Jason Sarber (758890), Nicolette Miranda (758894), Jennifer Tullai (758883), Helen Pham (758893), Jian Ding (163402), Scott Bailey (700449), Hai-Ming Tang (418016), Simon M. Bushell (758903), Sarita Yeola (758886), Pamela Tranter (758896), Elizabeth George (287460), Jonathan M. Solomon (758905), Pichai Raman (758882), Andrew M. Schumacher (758899), Cheryl Carson (758881), J. Martin Verkuyl (124311), Nan Ji (758897), Martin Henault (758884), Mark McPate (758888), George Marsh (758889), Danuta Lubicka (758892), Joseph J. Loureiro (758900), Rishi K. Jain (758898)   +31 more
core   +1 more source

Natural Variation of COLD and CATECHINS REGULATOR 1 Coordinately Fine‐Tunes Cold Tolerance and Tea Quality in Tea Plants

Advanced Science, EarlyView.
Multi‐trait genome‐wide association mapping identifies a central hub regulator, COLD AND CATECHINS REGULATOR 1 (CCR1), and its excellent natural allele variation, coordinately enhancing cold tolerance and promoting catechins biosyntheis. CsCCR1 interacts with CsCBF1/3 and is transcriptionally activated by CsLUX and CsKUA1 to promote catechins ...
Yanli Wang, Wei Tong, Qiong Wu, Didi Wu, Yanrui Zhang, Qijuan Gao, Fangdong Li, Zhaoliang Zhang, Wenjie Wang, Chuankui Song, Enhua Xia   +10 more
wiley   +1 more source

TRP-1 and TPR-2 coordinate SMD neuronal activities with head bending and mediate head muscle contractions. [PDF]

, 2018
(A, C) Representative images showing GCaMP3 fluorescence in the SMD soma of a flp-22p-Δ4::GCaMP3 transgenic worm during dorsal and ventral head bending of the indicated genotypes. The head region (left) and a higher magnification of the boxed area (right)
Jinmahn Kim (787021), Jihye Yeon (787022), Hyunmin Kim (198364), Hyun-Ho Lim (111865), Do-Young Kim (3331455), Eun Jo Du (842125), KyeongJin Kang (2545660), Daewon Moon (5353358), Jungha Kim (5353355), Kyuhyung Kim (651731)   +9 more
core   +1 more source

AI‐Assisted Digital Single‐Molecule Activity Tracker for Decoupling Intrinsic Heterogeneity from Photo‐Oxidative Damage in High‐Photon‐Flux Enzymology

Advanced Science, EarlyView.
Employing a digital single‐molecule activity tracker (dSMAT), this research demonstrates that high‐photon‐flux irradiation drives progressive oxidative scarring in polymerases. Unlike simple thermal denaturation, real‐time kinetic tracking dynamically visualizes enzymes degrading into multiple impaired subpopulations.
Anran Zheng, Qi Yang, Jinze Li, Fuqiang Ma, Xuefeng Wang, Zhen Guo, Chuanyu Li, Dongshu Li, Jia Yao, Zhiqi Zhang, Wei Zhang, Lianqun Zhou   +11 more
wiley   +1 more source