Results 101 to 110 of about 164,112 (301)

Discriminator‐Guided Inverse Folding for Multi‐Property Protein Design

Advanced Science, EarlyView.
Discriminator‐Guided Inverse Folding (DGIF) integrates multiple property predictors trained from single‐property datasets to guide protein sequence generation from a backbone structure. DGIF enables simultaneous improvement of thermostability and solubility without requiring multi‐property annotated datasets and generates designs that move toward the ...
Yuchuan Zheng, Chuyi Liu, Zhaoming Liu, Mao Su, Chenyu Tang, Xiang Zheng, Hao Zhang, Jingyuan Li   +7 more
wiley   +1 more source

Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study

BMC Infectious Diseases, 2019
Background Indoleamine 2, 3-dioxygenase (IDO) is a key enzyme in the degradation of tryptophan (Trp) to kynurenine (Kyn). We measured IDO activity as the Kyn to Trp ratio, and investigated whether IDO could be used to assess prognosis of acquired immune ...
Mengyan Wang, Xiaotian Dong, Ying Huang, Junwei Su, Xiahong Dai, Yongzheng Guo, Caiqin Hu, Qihui Zhou, Biao Zhu   +8 more
doaj   +1 more source

Trp-Cage Folding on Organic Surfaces [PDF]

, 2015
Trp-cage is an artificial miniprotein that is small, stable, and fast folding due to concerted hydrophobic shielding of a Trp residue by polyproline helices.
Sean A. Fischer (1339596), Zachary A. Levine (1337193), Joan-Emma Shea (1235013), Jim Pfaendtner (515248)   +3 more
core   +1 more source

A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis

Advanced Science, EarlyView.
This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen, Yuchen Li, Liang Zhang, Xiaosong Ma, Chenyin Peng, Chunting Yuan, Yu Wu, Kaiyu Zhao, Sheng Zhao, Jiazhuo Guo, Run Li, Ziqian Yan, Shule Ren, Yige Han, Xin Lin, Xinyue Li, Ming Li, Pingfang Yang, Shiyong Song   +18 more
wiley   +1 more source

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Frontiers in Cellular and Infection Microbiology, 2018
The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between ...
Jing Gao, Jing Gao, Jing Gao, Kang Xu, Kang Xu, Hongnan Liu, Hongnan Liu, Gang Liu, Gang Liu, Miaomiao Bai, Miaomiao Bai, Can Peng, Can Peng, Tiejun Li, Tiejun Li, Yulong Yin, Yulong Yin, Yulong Yin, Yulong Yin   +18 more
doaj   +1 more source

A TRP among the astrocytes

The Journal of Physiology, 2012
Abstract TRP channels were first identified as membrane proteins mediating phototransduction in fruit flies. Astrocytes were initially referred to as the silent elements of the nervous system. At the time these discoveries were made, few would have suspected TRP channels and astrocytes could contribute significantly to our understanding of brain ...
openaire   +3 more sources

Binding Mode between Trp-Dy(III) Complex and Herring Sperm DNA [PDF]

, 2009
By means of UV and fluorescence spectra, the binding ratios between Dy(III)(Trp)(3) and DNA. in physiological pH environment(pH7.40) were determined as n(Dy(III)(Trp)),:n(DNA) = 2:1 and n(Dy(III)):n(Trp)=1:3.
Xu, Y, Pan, HZ, Wang, XM, SW Univ Sci & Technol, Dept Chem, Sch Mat Sci & Engn, Mianyang 621010, Sichuan, Taiwan., Ding, LS, Wang, XM, Zhao, N, Wang, D   +6 more
core  

XPORT-Dependent Transport of TRP and Rhodopsin [PDF]

, 2011
SummaryTRP channels have emerged as key biological sensors in vision, taste, olfaction, hearing, and touch. Despite their importance, virtually nothing is known about the folding and transport of TRP channels during biosynthesis. Here, we identify XPORT (
Vasiljevic, Eva, Hardie, Roger C., Kimberley S. Brehm, Eva Vasiljevic, Liu, Che-Hsiung, Nansi Jo Colley, Roger C. Hardie, Rosenbaum, Erica E., Brehm, Kimberley S., Colley, Nansi Jo, Erica E. Rosenbaum, Che-Hsiung Liu   +11 more
core   +1 more source

Circulating Amino Acid Network Remodeling Reveals Systemic Metabolic Reprogramming Predictive of Colorectal Cancer Recurrence and Metastasis

Advanced Science, EarlyView.
Blood‐based amino acid patterns measured by 19F NMR reveal hidden metabolic changes in colorectal cancer. By analyzing how these amino acids interact as a network, machine learning models identify patients at higher risk of recurrence and metastasis.
Ji‐Yeon Lee, Jumi Kim, Taehan Yoon, So Hyun Kwon, Su Chan Park, Dohyun Chun, Dohyeong Kim, Eun Jung Park, Hyunwoo Kim, Ji Min Lee   +9 more
wiley   +1 more source

Identification of a Nonribosomal Peptide Analog With Activity Against Multiple Gram‐Positive Bacteria via a Synthetic Bioinformatic Natural Product Discovery Approach

Advanced Science, EarlyView.
The genome of Rhodococcus erythropolis D‐1 was analyzed by bioinformatic tools to mine a novel nonribosomal peptide synthetase (NRPS) gene cluster. A nonribosomal peptide analog ZURJC5 associated with the NRPS was chemically synthesized. Through structure‐activity relationship studies, ZURJC28 was ultimately obtained and showed antibacterial activity ...
Keyi Chen, Jiayi Liang, Yujia Wu, Jianan Xu, Yi Liu, Wenguang Wang, Xinhang Jiang, Benjie Gao, Yueyue Wang, Hui Jiang   +9 more
wiley   +1 more source