Results 101 to 110 of about 176,809 (302)

Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study

BMC Infectious Diseases, 2019
Background Indoleamine 2, 3-dioxygenase (IDO) is a key enzyme in the degradation of tryptophan (Trp) to kynurenine (Kyn). We measured IDO activity as the Kyn to Trp ratio, and investigated whether IDO could be used to assess prognosis of acquired immune ...
Mengyan Wang, Xiaotian Dong, Ying Huang, Junwei Su, Xiahong Dai, Yongzheng Guo, Caiqin Hu, Qihui Zhou, Biao Zhu   +8 more
doaj   +1 more source

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars, Anthony J Ricci, Grimm, Christian, Heller, Stefan, Anthony J. Ricci (212303), Ricci, Anthony J., Stefan Heller, Lars Becker (358879), Zhaohua Guo (383295), Zhaohua Guo, Stefan Heller (36641), Guo, Zhaohua, Lars Becker, Christian Grimm, Christian Grimm (84987), Heller Stefan, Ricci Anthony J., Becker Lars, Grimm Christian, Guo Zhaohua   +19 more
core   +2 more sources

Low‐Intensity Ultrasound‐Triggered Microbubble Cavitation Attenuates Diabetic Kidney Injury Partially by Reversing Endothelial Dysfunction

Advanced Science, EarlyView.
Non‐invasive low‐intensity pulsed ultrasound ‐triggered cavitation of clinically approved diagnostic‐grade microbubbles delivers favorable mechanical stimuli to renal microvasculature. This intervention restores renal microvascular homeostasis, alleviates DKD‐associated histological and functional damage, and suppresses inflammatory and fibrotic ...
Yubo Lai, Liang Zhang, Wenxin Tao, Jieyuan An, Lantian Wang, Zhaoyou Liu, Guodong Yang, Pengying Wu, Lijun Yuan   +8 more
wiley   +1 more source

Trp-Cage Folding on Organic Surfaces

, 2015
Trp-cage is an artificial miniprotein that is small, stable, and fast folding due to concerted hydrophobic shielding of a Trp residue by polyproline helices.
Sean A. Fischer (1339596), Zachary A. Levine (1337193), Joan-Emma Shea (1235013), Jim Pfaendtner (515248)   +3 more
core   +1 more source

Blue Light Receptor PHR2‐Mediated Spectrum Antiviral Immunity

Advanced Science, EarlyView.
Blue light suppresses RBSDV through the blue‐light receptor ZmPHR2, which interacts with ZmISP in chloroplasts to trigger ROS burst and antiviral defense. The viral effector P6 enhances ZmPHR2–ZmISP interaction, alters their distribution, and suppresses ROS.
Runyi Chen, Yuxin Tai, Xinyu Wang, Chunhua Mu, Xia Liu, Gongjian Li, Jiayi Liu, Xin Lu, Duo Shi, Zhiqiang Zhou, Jienan Han, Zhuanfang Hao, Mingshun Li, Degui Zhang, Hongjun Yong, Zhennan Xu, Jianfeng Weng, Xinhai Li   +17 more
wiley   +1 more source

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Frontiers in Cellular and Infection Microbiology, 2018
The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between ...
Jing Gao, Jing Gao, Jing Gao, Kang Xu, Kang Xu, Hongnan Liu, Hongnan Liu, Gang Liu, Gang Liu, Miaomiao Bai, Miaomiao Bai, Can Peng, Can Peng, Tiejun Li, Tiejun Li, Yulong Yin, Yulong Yin, Yulong Yin, Yulong Yin   +18 more
doaj   +1 more source

A TRP among the astrocytes

The Journal of Physiology, 2012
Abstract TRP channels were first identified as membrane proteins mediating phototransduction in fruit flies. Astrocytes were initially referred to as the silent elements of the nervous system. At the time these discoveries were made, few would have suspected TRP channels and astrocytes could contribute significantly to our understanding of brain ...
openaire   +3 more sources

Yoda1‐Functionalized Nanozymes Coordinate Piezo1 Activation and Mitochondrial Protection to Reprogram the Diabetic Osteoimmune Micromilieu and Promote Vascularized Bone Repair

Advanced Science, EarlyView.
Diabetic bone defects remain a critical clinical challenge. A 3D‐printed BCPG‐MF@Y scaffold, embedding Yoda1‐functionalized manganese dioxide‐ferritin nanozymes, scavenges mtROS, suppresses the cGAS–STING pathway, and reverses cellular senescence, while Yoda1 activates Piezo1 to direct BMSCs fate to synergistically reprogram the osteoimmune ...
Qing‐Song Deng, Ang Wang, Ren Zhang, Xu‐Ran Li, Po‐Lin Liu, Shu‐Hang He, Zi‐Yin Han, Zhi‐Han Shen, Zhan‐Ying Wei, Chang‐Ru Zhang, Fei Wang, Helen Dawes, Jian Lu, Tong‐He Zhu, Jin‐Zhong Zhao, Shang‐Chun Guo, Shi‐Cong Tao   +16 more
wiley   +1 more source

Serum tryptophan-kynurenine metabolites served as biomarkers of disease activity in rheumatoid arthritis and linked to immune imbalance

Arthritis Research & Therapy
Background Immune imbalance caused by imbalanced helper T(Th)17/regulatory T (Treg) and follicular helper T (Tfh)/follicular regulatory T (Tfr) cells drives the onset of rheumatoid arthritis (RA) fundamentally.
Ruihe Wu, Baochen Li, Rui Su, Xiaoyang Liu, Anqi Gao, Jing Luo, Chong Gao, Xiaofeng Li, Caihong Wang   +8 more
doaj   +1 more source

Bioengineered Stroma‐Camouflaged Nanovesicles Disrupt the IDO1/CD276 Immunosuppressive Circuit to Reinvigorate Antitumor Immunity

Advanced Science, EarlyView.
Bioengineered stroma‐camouflaged nanovesicles (AM@UIO‐BMS/DOX) convert the immunosuppressive tumor niche into an immunoresponsive milieu by disrupting the IDO1/CD276 circuit. Anti‐CD276 membrane camouflage guides tumor accumulation and deep penetration, enabling controlled co‐delivery of DOX and the IDO1 inhibitor BMS‐986205.
Ziqi Zhang, Jing Luo, Mengdi Zhang, Jingying Zhuang, Yating Zheng, Yang Zhang, Zhihong Huang, Xinhua Lin, Shuzhen Xu, Hong Yao, Gang Liu, Bing Chen   +11 more
wiley   +1 more source