Results 81 to 90 of about 164,112 (301)

TRP channels in schistosomes

International Journal for Parasitology: Drugs and Drug Resistance, 2016
Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this
Swarna Bais, Robert M. Greenberg
openaire   +3 more sources

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars, Anthony J Ricci, Grimm, Christian, Heller, Stefan, Anthony J. Ricci (212303), Ricci, Anthony J., Stefan Heller, Lars Becker (358879), Zhaohua Guo (383295), Zhaohua Guo, Stefan Heller (36641), Guo, Zhaohua, Lars Becker, Christian Grimm, Christian Grimm (84987)   +14 more
core   +1 more source

Redox‐Dependent Chaperoning of GBF1 Condensates Regulates Seed Germination in Arabidopsis

Advanced Science, EarlyView.
In dormant seeds (low ROS), GBF1 forms liquid condensates to repress the germination gene CathB3, and the chaperone GIP1 maintains condensate liquidity and repressive activity. Upon imbibition (high ROS), ROS oxidize GIP1 during germination, impairing its chaperone function.
Yunying Wang, Xiaofeng Fang
wiley   +1 more source

d-Trp in site 1. [PDF]

, 2016
Left: Part of the electron density map in site 2 with d-Trp bound. The model conformation for the α2bβ3-loop is in good agreement with the map (2Fo-Fc map contoured at 1.0 σ (blue mesh) and Fo-Fc omit map contoured at 3.0 σ (green mesh)).
Nicola J. Blackmore (2634682), Sebastian Reichau (2181230), Emily J. Parker (1397425), Wanting Jiao (1883032)   +3 more
core   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

Taguchi-based multi-response statistical optimization and performance assessment of high-strength concrete incorporating weathered crystalline rock fine aggregate

Scientific Reports
This study presents a detailed statistical optimization methodology for improving the performance of high-strength concrete through the strategic integration of weathered crystalline rock (WCR) fine aggregate. Utilizing Taguchi L5 orthogonal array design,
Shaji M. Jamal, C. Ramesh Kannan, D. Manikandan, Krishnaraj Ramaswamy   +3 more
doaj   +1 more source

Heterojunction‐Engineered Mass Spectrometry Platform for Deciphering Serum Metabolic Fingerprints in Diagnosis of Respiratory Diseases

Advanced Science, EarlyView.
Hollow Co3O4/TiO2 heterojunctions are engineered for high‐throughput laser desorption/ionization mass spectrometry. The built‐in electric field drives efficient charge separation and photothermal conversion, while the hierarchical mesoporous network enables robust salt and protein tolerance.
Junyu Chen, Chaoqi Wang, Xi Yu, Yuming Jiang, Yijiao Qu, Huihui Fu, Yuyin Bu, Xiaoyong Zhang, Zongxiu Nie   +8 more
wiley   +1 more source

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac‑d‑Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH₂ (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility [PDF]

, 2016
Metastin/kisspeptin is an endogenous ligand of KISS1 Receptor (KISS1R). Metastin and KISS1R are suggested to play crucial roles in regulating the secretion of gonadotropin-releasing hormone (GnRH), and continuous administration of metastin derivatives ...
Naoki Nishizawa (1773700), Shunichirou Tsutsumi (1920907), Junko Ban (1773709), Tetsuya Ohtaki (1773685), Masami Kusaka (1773703), Yukihiro Ikeda (1773718), Hisanori Matsui (1773688), Satoshi Kumano (3128166), Yoshihiro Takatsu (1773712), Taiji Asami (1773697), Shin-ichi Matsumoto (1773706), Masashi Yamaguchi (276947), Atsushi Kiba (1773691), Fumio Itoh (52795)   +13 more
core   +3 more sources

Tryptophan in the mouse diet is essential for embryo implantation and decidualization

Frontiers in Endocrinology
IntroductionNutritional deficiency occurs frequently during pregnancy and breastfeeding. Tryptophan (Trp), an essential amino acid which is critical for protein synthesis, serves as the precursor for serotonin, melatonin, and kynurenine (Kyn).
Si-Ting Chen, Si-Ting Chen, Feng Ran, Wen-Wen Shi, Cheng-Kan Liu, Peng-Chao Wang, Hui-Na Luo, Zeng-Ming Yang, Zeng-Ming Yang   +8 more
doaj   +1 more source