Results 81 to 90 of about 176,809 (302)

Architecture of Nanoantioxidant Based on Mesoporous Organosilica Trp-Met-PMO with Dipeptide Skeleton

, 2023
A nanoantioxidant of mesoporous organosilica (Trp-Met-PMO) based on the framework of tryptophan–methionine dipeptide was first designed and constructed by condensation between self-created dipeptide organosilica precursor (Trp-Met-Si) and ...
Du, Yijing, Guo, Cheng, Cheng Guo, Wanli Zhou, Wang, Jianqiang, Jianqiang Wang, Yunqiao Dai, Haohua Ma, Dai, Yunqiao, Yijing Du, Zhou, Wanli, Ma, Haohua   +11 more
core   +1 more source

TRP channels in schistosomes

International Journal for Parasitology: Drugs and Drug Resistance, 2016
Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this
Swarna Bais, Robert M. Greenberg
openaire   +3 more sources

Chronic Stress Promotes Gastric Cancer Metastasis by Inducing Microbiota‐Associated Kynurenine Accumulation and Macrophage Remodeling

Advanced Science, EarlyView.
Chronic stress reshapes the gut microbiota and enriches Lactobacillus reuteri, promoting microbiota‐associated kynurenine accumulation through altered tryptophan metabolism. Kynurenine drives immunosuppressive remodeling of tumor‐associated macrophages through TNFR2–C/EBPβ signaling, thereby enhancing gastric cancer dissemination.
Sicheng Zhao, Zhiyuan Song, Jingcheng Zhang, Jiaheng Lou, Shuo Zhang, Boqiang Liu, Yunhai Wei, Fengmei Qiu, Tao Jiang, Guangji Zhang   +9 more
wiley   +1 more source

AI-enhanced operation and control of isolated AC micro-grids with renewable energy and energy storage systems

Discover Applied Sciences
The proposed control strategy aims to get the most power possible from a variety of energy sources in an isolated AC Microgrid by keeping a steady energy surplus without needing extra loads or special communication infrastructure. It uses the Microgrid’s
Sathishkumar Ramasamy, Sriram Anbalagan, D. Manikandan, Krishnaraj Ramaswamy   +3 more
doaj   +1 more source

Glu-Trp-ONa or its acylated analogue (R-Glu-Trp-ONa) administration enhances the wound healing in the model of chronic skin wounds in rabbits

, 2015
Maxim A Shevtsov,1,2 Larisa V Smagina,1 Tatiana A Kudriavtceva,3 Sergey V Petlenko,4 Irina V Voronkina1 1Institute of Cytology of the Russian Academy of Sciences (RAS), St Petersburg, Russia; 2IP Pavlov State Medical University of St  ...
Shevtsov MA, Smagina LV, Kudriavtceva TA, Petlenko SV, Voronkina IV   +4 more
core  

Tumor Mechanical Remodeling via Bidirectional Calcium Redistribution Enables Deep Photothermal‐Immunotherapy

Advanced Science, EarlyView.
A bidirectional calcium‑redistributing nanomodulator rewires intra‑extracellular calcium homeostasis to remodel tumor mechanical microenvironments. It softens tumor stroma to facilitate deep tissue penetration while stiffening tumor cells, evoking amplified immunogenic cell death and robust CTL infiltration, which achieves potent deep photothermal ...
Hongjuan Zhao, Jinpei Sun, Chenxi Zhao, Yuting Cang, Keyu Zong, Yuxin Guo, Yajing Wang, Di Meng, Qingling Song, Lei Wang   +9 more
wiley   +1 more source

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

Design and Synthesis of an Investigational Nonapeptide KISS1 Receptor (KISS1R) Agonist, Ac‑d‑Tyr-Hydroxyproline (Hyp)-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH₂ (TAK-448), with Highly Potent Testosterone-Suppressive Activity and Excellent Water Solubility

, 2016
Metastin/kisspeptin is an endogenous ligand of KISS1 Receptor (KISS1R). Metastin and KISS1R are suggested to play crucial roles in regulating the secretion of gonadotropin-releasing hormone (GnRH), and continuous administration of metastin derivatives ...
Naoki Nishizawa (1773700), Shunichirou Tsutsumi (1920907), Junko Ban (1773709), Tetsuya Ohtaki (1773685), Masami Kusaka (1773703), Yukihiro Ikeda (1773718), Hisanori Matsui (1773688), Satoshi Kumano (3128166), Yoshihiro Takatsu (1773712), Taiji Asami (1773697), Shin-ichi Matsumoto (1773706), Masashi Yamaguchi (276947), Atsushi Kiba (1773691), Fumio Itoh (52795)   +13 more
core   +2 more sources

Tryptophan in the mouse diet is essential for embryo implantation and decidualization

Frontiers in Endocrinology
IntroductionNutritional deficiency occurs frequently during pregnancy and breastfeeding. Tryptophan (Trp), an essential amino acid which is critical for protein synthesis, serves as the precursor for serotonin, melatonin, and kynurenine (Kyn).
Si-Ting Chen, Si-Ting Chen, Feng Ran, Wen-Wen Shi, Cheng-Kan Liu, Peng-Chao Wang, Hui-Na Luo, Zeng-Ming Yang, Zeng-Ming Yang   +8 more
doaj   +1 more source

Prolonged antinociceptive activity of pseudodipeptide analogues of Lys-Trp(Nps) and Trp(Nps)-Lys [PDF]

, 1992
Peptide bend susbstitution in the molecules of Lys-Trp(Nps) (LTN) and Trp-(Nps)Lys (TNL) by an aminomethylene and ketomethylene bond, respectively, afforded pseudodipeptides with analgesic activity.
López, A. E., González-Muñiz, R., Ceballos, María L. de, Gómez-Monterrey, Isabel, Bravo, A., Harto, J. R., García-López, M. Teresa, Río, Joaquín del, DEL RIO J., GARCIA LOPEZ M. T., LOPEZ A. L., BRAVO A., GOMEZ MONTERREY, ISABEL MARIA, HARTO J. R., GONZALEZ MUNIZ R., García-López, M. T., LOPEZ DE CEBALLOS M.   +16 more
core   +1 more source