Results 61 to 70 of about 176,809 (302)

Chlamydia Exploit the Mammalian Tryptophan-Depletion Defense Strategy as a Counter-Defensive Cue to Trigger a Survival State of Persistence.

open access: yesFrontiers in Cellular and Infection Microbiology, 2014
We previously proposed that in Chlamydiaceae rapid vegetative growth and a quiescent state of survival (persistence) depend upon alternative protein translational profiles dictated by host tryptophan (Trp) availability.
Carol A Bonner   +2 more
doaj   +1 more source

Englerin A selectivity against TRP family and non-TRP family ion channels.

open access: yes, 2015
Englerin A selectivity against TRP family and non-TRP family ion channels.
Lei Xu (78676)   +31 more
core   +1 more source

Sensing with TRP channels [PDF]

open access: yes, 2005
Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photoreceptors.
Bernd Nilius   +7 more
core   +1 more source

MEC-4 and TRP-4 act in parallel to mediate ultrasound-evoked behavioral changes.

open access: yes, 2022
Frequency of large reversals (more than two head bends) in strains ectopically expressing TRP-4. Large reversal frequency with (A) AWC::trp-4 and (B) ASH::trp-4 in different backgrounds at different peak negative pressures are quantified.
Connor Weiss (12506633)   +5 more
core   +1 more source

Computationally Evidence‐Grounded Sequence‐First Design of Peptide Binders

open access: yesAdvanced Science, EarlyView.
BOND‐PEP enables controllable, sequence‐first peptide binder design by grounding generation in binding evidence retrieved for each target. It uses topology‐conditioned message passing to integrate relevant peptide examples with the target protein sequence, forming a residue‐level representation that guides the generation of diverse, target‐specific ...
Wenze Ding
wiley   +1 more source

Formation and Characterization of a Single Trp-Trp Cross-link in Indolicidin That Confers Protease Stability without Altering Antimicrobial Activity* [PDF]

open access: yes, 2000
Indolicidin is a 13-residue cationic, antimicrobial peptide-amide isolated from the cytoplasmic granules of bovine neutrophils. The unique composition of indolicidin distinguishes it from alpha-helical and beta-structured cationic peptides, because five ...
Henschen, Agnes H   +5 more
core   +1 more source

Dual‐Responsive Hydrogels Integrate Bioelectrical Stimulation and Piezo‐Photocatalysis for Regenerative Treatment of Infected Wounds

open access: yesAdvanced Science, EarlyView.
A wireless, dual‐responsive hydrogel (PVA/(PVDF‐TrFE)/BiOClBr@PDA) is developed to promote efficient regeneration of infected wounds by integrating piezoelectric stimulation with piezo‐photocatalytic pathways. Under simultaneous light and ultrasonic stimulation, the hydrogel generates therapeutic electrical cues and reactive oxygen species, disrupting ...
Baoying Dai   +15 more
wiley   +1 more source

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

open access: yesOncoImmunology, 2018
Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction.
Isabell Adam   +13 more
doaj   +1 more source

OsCPK12‐OsATPD1 Module Regulates Photosynthetic Acclimation to Light Stress in Rice

open access: yesAdvanced Science, EarlyView.
OsCPK12 interacts and phosphorylates OsAtpD1 at Ser8 in its transit peptide. This phosphorylation promote its chloroplast translocation, thereby maintaining ATP synthase activity and proton gradient (ΔpH) homeostasis and regulating photosynthetic acclimation, photoprotection, and repair under light stress.
Beifang Wang   +17 more
wiley   +1 more source

Reconstitution of lysosomal NAADP-TRP-ML1 signaling pathway and its function in TRP-ML1−/−cells

open access: yes, 2011
It is well known that the mutation of TRP-ML1 (transient receptor potential-mucolipin-1) causes mucolipidosis IV, a lysosomal storage disease. Given that lysosomal nicotinic acid adenine dinucleotide phosphate (NAADP)-Ca2+release channel activity is ...
Ming Xu   +3 more
core   +1 more source

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