Results 51 to 60 of about 176,809 (302)

RNAi in the Rhizarian Phytopathogen Plasmodiophora brassicae: The Causal Agent of Clubroot Disease in Cruciferous Crops

Advanced Science, EarlyView.
This study uncovers an unusual RNAi pathway in the rhizarian pathogen Plasmodiophora brassicae. In the absence of Dicer, a Drosha‐like RNase III protein supports the biogenesis of predominant 21‐nt small RNAs, and two Argonaute proteins mediate small RNA‐guided silencing.
Xiong Zhang, Yupo Wu, Jiachang Hou, Lixia Gao, Longqi Pan, Cuicui Shen, Chuanji Zhao, Feng Gao, Yi Zhang, Li Ren, Xiaoping Fang, Xiaoling Dun, Shengyi Liu, Lijiang Liu   +13 more
wiley   +1 more source

A successive framework for brain tumor interpretation using Yolo variants

Scientific Reports
Accurate identification and segmentation of brain tumors in Magnetic Resonance Imaging (MRI) images are critical for timely diagnosis and treatment. MRI is frequently used to diagnose these disorders; however medical professionals find it challenging to ...
S. Priyadharshini, Ramasubramanian Bhoopalan, D. Manikandan, Krishnaraj Ramaswamy   +3 more
doaj   +1 more source

Gut Microbiota Metabolite Indole Propionic Acid Targets Tryptophan Biosynthesis in Mycobacterium tuberculosis

mBio, 2019
Indole propionic acid (IPA), produced by the gut microbiota, is active against Mycobacterium tuberculosis in vitro and in vivo. However, its mechanism of action is unknown.
Dereje Abate Negatu, Yoshiyuki Yamada, Yu Xi, Mei Lin Go, Matthew Zimmerman, Uday Ganapathy, Véronique Dartois, Martin Gengenbacher, Thomas Dick   +8 more
doaj   +1 more source

Ac-Trp-DPhe(p-I)-Arg-Trp-NH₂, a 250-Fold Selective Melanocortin‑4 Receptor (MC4R) Antagonist over the Melanocortin‑3 Receptor (MC3R), Affects Energy Homeostasis in Male and Female Mice Differently

, 2016
The melanocortin-4 receptor (MC4R) has been indicated as a therapeutic target for metabolic disorders such as anorexia, cachexia, and obesity. The current study investigates the in vivo effects on energy homeostasis of a 15 nM MC4R antagonist SKY2-23-7 ...
Stacey L. Wilber (2886779), Amy Andreasen (2886776), Zhimin Xiang (2719438), Cody J. Lensing (2574229), Carrie Haskell-Luevano (1322436), Jay W. Schaub (2886773), Danielle N. Adank (2574226), Skye R. Doering (1374147)   +7 more
core   +1 more source

Organellar TRP channels [PDF]

Nature Structural & Molecular Biology, 2018
Mammalian transient receptor potential (TRP) channels mediate Ca2+ flux and voltage changes across membranes in response to environmental and cellular signals. At the plasma membrane, sensory TRPs act as neuronal detectors of physical and chemical environmental signals, and receptor-operated (metabotropic) TRPs decode extracellular neuroendocrine cues ...
Xiaoli Zhang, Meiqin Hu, Yexin Yang, Haoxing Xu   +3 more
openaire   +2 more sources

An Activity‐Reinforced P‐Modified Single‐Atom Cu Nanozyme Potentiates IDO Blockade‐Induced Tumor Radiotherapy

Advanced Science, EarlyView.
A phosphorus‐modified single‐atom copper nanozyme delivering the IDO1 inhibitor 1‐methyl‐tryptophan enhances breast cancer radioimmunotherapy by simultaneously relieving hypoxia and inducing immunogenic cell death through dual enzyme activities while blocking tryptophan metabolism to suppress regulatory T cell function.
Wei Zhao, Songliu Hu, Zhanggui Wang, Liqun Wang, Liming Zhang, Qi Li, Hua Tang, Yang Zhong, Zhongxian Zhang, Kelong Fan, Shipeng Ning, Xiyun Yan   +11 more
wiley   +1 more source

Optimized IoT protocol stack for seamless smart home communication using Random Forest-based interoperability analysis

Scientific Reports
This paper introduces an optimised and harmonised Internet of Things (IoT) protocol stack aimed at enabling seamless device communication in smart home settings, utilising a Random Forest-based interworking analysis framework.
A. Sriram, D. Manikandan, R. Venketesan, Krishnaraj Ramaswamy   +3 more
doaj   +1 more source

Sulfoxide-mediated Cys-Trp-selective bioconjugation that enables protein labeling and peptide heterodimerization [PDF]

A method was developed that enables the magnesium chloride (MgCl2)-activated S-acetamidomethyl cysteine sulfoxide (Cys(Acm)(O)) to induce the sp2(C−H) sulfenylation of the indole ring of Trp residues.
Kota, Hidaka, Harunori, Yoshikawa, Kento, Ohkawachi, Hidetaka, Kosako, Akira, Otaka, Wataru, Nomura, Kohei, Nishino, Tetsuro, Yoshimaru, Daishiro, Kobayashi, Junya, Hayashi, Kiyomi, Nigorikawa, Masaya, Deda, Yutaka, Kohmura, Naozumi, Ishimaru, Toyomasa, Katagiri, Takaaki, Tsunematsu   +15 more
core   +2 more sources

Calmodulin binds to Drosophila TRP with an unexpected mode [PDF]

, 2021
Drosophila TRP is a calcium-permeable cation channel essential for fly visual signal transduction. During phototransduction, Ca2+ mediates both positive and negative feedback regulation on TRP channel activity, possibly via binding to calmodulin (CaM ...
Asteriti, Sabrina, Sun, Ziling, Hardie, Roger C., Ye, Fei, Liu, Wei, Chen, Weidi, Wan, Jun, Chen, Zijing, Zhang, Mingjie, Shen, Zeyu, Montell, Craig, Hardie, Roger C, Mingjie Zhang, Weidi Chen, Craig Montell, Roger C. Hardie, Zijing Chen, Sabrina Asteriti, Fei Ye, Ziling Sun, Jun Wan, Wei Liu, Zeyu Shen   +22 more
core   +2 more sources

TED1 Promotes the Assembly of SCFD3‐D14‐D53 to Reinforce Strigolactone Signaling in Rice

Advanced Science, EarlyView.
This study identifies TED1 as a positive regulator of strigolactones (SL) signaling in rice. The ted1 mutants display dwarfism and increased tillering with significantly reduced SLs sensitivity. Through its longer C‐terminal region, TED1 interacts with D53 and D14 to promote the assembly of SCFD3‐D14‐D53, thereby facilitating the efficient ...
Sheng Luo, Chuanyin Wu, Miao Feng, Wenfan Luo, Rong Miao, Jinsheng Qian, Fan Wang, Chunlei Zhou, Bojuan Liu, Jiale Shao, Ziqi Xun, Yehui Xiong, Zhichao Zhao, Cailin Lei, Shanshan Zhu, Yulong Ren, Xin Wang, Xiuping Guo, Haiyang Wang, Zichao Li, Zhijun Cheng, Qibing Lin, Jianmin Wan   +22 more
wiley   +1 more source