Results 51 to 60 of about 173,869 (207)

Chlamydia Exploit the Mammalian Tryptophan-Depletion Defense Strategy as a Counter-Defensive Cue to Trigger a Survival State of Persistence.

open access: yesFrontiers in Cellular and Infection Microbiology, 2014
We previously proposed that in Chlamydiaceae rapid vegetative growth and a quiescent state of survival (persistence) depend upon alternative protein translational profiles dictated by host tryptophan (Trp) availability.
Carol A Bonner   +2 more
doaj   +1 more source

Sensing with TRP channels [PDF]

open access: yes, 2005
Drosophila melanogaster flies carrying the trp (transient receptor potential) mutation are rapidly blinded by bright light, because of the absence of a Ca2+-permeable ion channel in their photoreceptors.
Bernd Nilius   +7 more
core   +1 more source

Upregulation of tryptophanyl-tRNA synthethase adapts human cancer cells to nutritional stress caused by tryptophan degradation

open access: yesOncoImmunology, 2018
Tryptophan (Trp) metabolism is an important target in immuno-oncology as it represents a powerful immunosuppressive mechanism hijacked by tumors for protection against immune destruction.
Isabell Adam   +13 more
doaj   +1 more source

A novel ion channel formed by interaction of TRPML3 with TRPV5. [PDF]

open access: yes, 2013
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the pore
Becker, Lars   +14 more
core   +2 more sources

Sustainable and Intelligent Automation Framework for Aerospace Alloys Using Multi-Agent Deep Reinforcement Learning

open access: yesAutomation
Advanced aerospace alloys such as titanium alloy (Ti-6Al-4V) are widely employed in critical applications owing to their excellent strength-to-weight ratio and corrosion resistance.
Nagadeepan Anbazhagan   +2 more
doaj   +1 more source

Adaptive speed control of BLDC motors for enhanced electric vehicle performance using fuzzy logic

open access: yesScientific Reports
This study investigates the use of a closed-loop speed control approach based on fuzzy logic for brushless DC (BLDC) motors in Electric Vehicle (EV) applications.
R. Shenbagalakshmi   +5 more
doaj   +1 more source

Effects of tryptophan and probiotic supplementation on growth and behavior in quail

open access: yesPoultry Science, 2020
In laying hens, a diet supplemented with tryptophan (Trp) has been shown to affect their pecking behavior. However, unlike this positive effect, Trp is also involved in negative effects on behavior and stress through indolic pathways.
A. Yıldırım   +4 more
doaj   +1 more source

Phylogenetics Identifies Two Eumetazoan TRPM Clades and an Eighth TRP Family, TRP Soromelastatin (TRPS)

open access: yesMolecular Biology and Evolution, 2020
Abstract Transient receptor potential melastatins (TRPMs) are most well known as cold and menthol sensors, but are in fact broadly critical for life, from ion homeostasis to reproduction. Yet, the evolutionary relationship between TRPM channels remains largely unresolved, particularly with respect to the placement of several highly ...
Nathaniel J Himmel   +2 more
openaire   +2 more sources

Trp channels and itch [PDF]

open access: yesSeminars in Immunopathology, 2015
Itch is a unique sensation associated with the scratch reflex. Although the scratch reflex plays a protective role in daily life by removing irritants, chronic itch remains a clinical challenge. Despite urgent clinical need, itch has received relatively little research attention and its mechanisms have remained poorly understood until recently.
Shuohao, Sun, Xinzhong, Dong
openaire   +2 more sources

TRP channels in schistosomes

open access: yesInternational Journal for Parasitology: Drugs and Drug Resistance, 2016
Praziquantel (PZQ) is effectively the only drug currently available for treatment and control of schistosomiasis, a disease affecting hundreds of millions of people worldwide. Many anthelmintics, likely including PZQ, target ion channels, membrane protein complexes essential for normal functioning of the neuromusculature and other tissues. Despite this
Swarna Bais, Robert M. Greenberg
openaire   +3 more sources

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