Results 31 to 40 of about 173,869 (207)

Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol

eLife, 2019
The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek, Brett Boonen, Alejandro López-Requena, Ariel Talavera, Yeranddy A Alpizar, Debapriya Ghosh, Nele Van Ranst, Bernd Nilius, Thomas Voets, Karel Talavera   +9 more
doaj   +1 more source

Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries. [PDF]

PLoS ONE, 2010
BACKGROUND: As tumor antigen-specific CD4+ T cells can mediate strong therapeutic anti-tumor responses in melanoma patients we set out to establish a comprehensive screening strategy for the identification of tumor-specific CD4+ T cell epitopes suitable ...
Wolfram Osen, Sabine Soltek, Mingxia Song, Barbara Leuchs, Julia Steitz, Thomas Tüting, Stefan B Eichmüller, Xuan-Duc Nguyen, Dirk Schadendorf, Annette Paschen   +9 more
doaj   +1 more source

Trp

, 2022
Decoding Trp regulatory ...
Guoji Guo (1374606)
core   +1 more source

A novel approach for the segmentation of retinal images by integration K-means clustering algorithm with graph cut for image segmentation

Scientific Reports
Diabetic retinopathy (DR) is a foremost cause of vision impairment, characterized by the presence of microaneurysms, exudates, and other intricate retinal lesions.
Ramasubramanian Bhoopalan, S. Priyadharshini   +1 more
doaj   +1 more source

Pan-cancer analyses reveal the genetic and pharmacogenomic landscape of transient receptor potential channels

npj Genomic Medicine, 2022
Transient-receptor potential (TRP) channels comprise a diverse family of ion channels, which play important roles in regulation of intracellular calcium.
Tao Pan, Yueying Gao, Gang Xu, Ping Zhou, Si Li, Jing Guo, Haozhe Zou, Qi Xu, Xiaoyan Huang, Juan Xu, Yongsheng Li   +10 more
doaj   +1 more source

Pan-Cancer Analysis of the TRP Family, Especially TRPV4 and TRPC4, and Its Expression Correlated with Prognosis, Tumor Microenvironment, and Treatment Sensitivity

Biomolecules, 2023
Background: Transient receptor potential (TRP) channels are involved in various physiological, pathological, and tumorigenesis-related processes. However, only a few studies have comprehensively analyzed TRP family members and their association with ...
Zhenghao Chen, Youquan Zhao, Ye Tian, Rui Cao, Donghao Shang   +4 more
doaj   +1 more source

Trp-rich sequence motifs in the gp41 region of Env.

, 2019
The figure was generated using the AnalyzeAlign database of the Los Alamos National Laboratory (http://www.hiv.lanl.gov/) based on the curated alignment of 6636 sequences.
Mark Sullivan (459776), Mark E. Dumont (1640836), Hong Zhu (109912), Elizabeth Mathew (5870612), Jeffrey Zuber (1640839), James J. Kobie (7365761), Michael S. Piepenbrink (7365758), Sara M. Connelly (1640833)   +7 more
core   +1 more source

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH₂ versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH₂: A Bivalent Advantage

, 2017
Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro; however, studies of their functional in vivo effects have been limited.
Sathya M. Schnell (2574232), Katie T. Freeman (3644092), Stacey L. Wilber (2886779), Adam T. Zarth (1368882), Cody J. Lensing (2574229), Robert C. Speth (605293), Carrie Haskell-Luevano (1322436), Danielle N. Adank (2574226)   +7 more
core   +1 more source

TRP channels at a glance [PDF]

Journal of Cell Science, 2004
The t ransient r eceptor p otential (TRP) superfamily consists of a diverse set of proteins whose primary function is to regulate the plasma membrane permeability of animal cells to a variety of ions.
Raghu, Padinjat, Simon, Andrews
openaire   +2 more sources

AAV9-Mediated Overexpression of TRPM4 Increases the Incidence of Stress-Induced Ventricular Arrhythmias in Mice

Frontiers in Physiology, 2019
Ca2+ activated non-selective (CAN) cation channels have been described in cardiomyocytes since the advent of the patch clamp technique. It has been hypothesized that this type of ion channel contributes to the triggering of cardiac arrhythmias.
Andy Pironet, Ninda Syam, Frone Vandewiele, Chris Van den Haute, Sara Kerselaers, Silvia Pinto, Greetje Vande Velde, Rik Gijsbers, Rudi Vennekens   +8 more
doaj   +1 more source