Results 11 to 20 of about 164,112 (301)
Ψ and χ Angle Constrains at the C‑Terminus Trp Position of the Melanotropin Tetrapeptide Ac-His‑d‑Phe-Arg-Trp-NH2 Lead to Potent and Selective Agonists at hMC1R and hMC4R [PDF]
, 2023 Melanocortin receptors (MCRs) are a family of G protein-coupled receptors that regulate important physiological functions. Yet, drug development targeting MCRs is hindered by potential side effects due to a lack of receptor subtype-selective ligands with
Yang Zhou (65942) +4 more
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TRP channels in hypertension [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Pulmonary and systemic arterial hypertension are associated with profound alterations in Ca(2+) homeostasis and smooth muscle cell proliferation. A novel class of non-selective cation channels, the transient receptor potential (TRP) channels, have emerged at the forefront of research into hypertensive disease states.
Firth, Amy L. +2 more
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Neuron, 2005 Transient receptor potential (TRP) ion channels are molecular gateways in sensory systems, an interface between the environment and the nervous system. Several TRPs transduce thermal, chemical, and mechanical stimuli into inward currents, an essential first step for eliciting thermal and pain sensations.
Wang, Haibin, Woolf, Clifford J.
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Annual Review of Biochemistry, 2007 The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains.
Kartik, Venkatachalam, Craig, Montell
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Current Biology, 2008 In the last decade, studies of transient receptor potential (TRP) channels, a superfamily of cation-conducting membrane proteins, have significantly extended our knowledge about the molecular basis of sensory perception in animals. Due to their distinct activation mechanisms and biophysical properties, TRP channels are highly suited to function in ...
Damann, Nils +2 more
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TRP-1 and TRP-2 are required for head steering locomotion. [PDF]
, 2018 (A) Schematic of the SMD neurons in C. elegans and the values analyzed during forward movement. (B) A phylogenetic tree of the TRPC subfamily channels. (C) The genomic locations (above) and structures (below) of the trp-1 and trp-2 genes.
Jinmahn Kim (787021) +9 more
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TRP-1 and TRP-2 are stretch-sensitive proprioceptive receptors. [PDF]
, 2018 (A) Heat maps and the average turning angle for indicated genotypes. n = 20 for each genotype. (B) Average wave width of the indicated genotypes. n = 50 for each genotype.
Jinmahn Kim (787021) +9 more
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TRP Channels in Digestive Tract Cancers. [PDF]
, 2020 Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis.
Borgström, Anna +7 more
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Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]
, 2007 The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J +4 more
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