Results 11 to 20 of about 163,766 (299)
, 2023 Melanocortin receptors (MCRs) are a family of G protein-coupled receptors that regulate important physiological functions. Yet, drug development targeting MCRs is hindered by potential side effects due to a lack of receptor subtype-selective ligands with
Yang Zhou (65942) +4 more
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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Pulmonary and systemic arterial hypertension are associated with profound alterations in Ca(2+) homeostasis and smooth muscle cell proliferation. A novel class of non-selective cation channels, the transient receptor potential (TRP) channels, have emerged at the forefront of research into hypertensive disease states.
Firth, Amy L. +2 more
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Neuron, 2005 Transient receptor potential (TRP) ion channels are molecular gateways in sensory systems, an interface between the environment and the nervous system. Several TRPs transduce thermal, chemical, and mechanical stimuli into inward currents, an essential first step for eliciting thermal and pain sensations.
Wang, Haibin, Woolf, Clifford J.
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Annual Review of Biochemistry, 2007 The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains.
Kartik, Venkatachalam, Craig, Montell
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Current Biology, 2008 In the last decade, studies of transient receptor potential (TRP) channels, a superfamily of cation-conducting membrane proteins, have significantly extended our knowledge about the molecular basis of sensory perception in animals. Due to their distinct activation mechanisms and biophysical properties, TRP channels are highly suited to function in ...
Damann, Nils +2 more
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TRP Channels in Digestive Tract Cancers. [PDF]
, 2020 Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis.
Borgström, Anna +7 more
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Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]
, 1994 The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Strasburger, Christian J. +14 more
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Journal of Photochemistry and Photobiology, 2020 7-Fluorotryptophan (7F-Trp) is an important noncanonical derivative of tryptophan (Trp) amino acid which depicts high in vivo stability for the positron emission tomography imaging of Trp metabolism.
Tonima Nandy +2 more
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Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]
, 2010 The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov +18 more
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Journal of Applied Poultry Research, 2023 SUMMARY: The current experiment was conducted to evaluate tryptophan (Trp) biomass as an alternative to conventional crystalline Trp in broiler diets. In a growth trial, a total of 288 eight-day-old chicks were randomly allotted to 1 of 3 treatments with
J.H. Lee +4 more
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