Results 11 to 20 of about 173,869 (207)
TRP channels in hypertension [PDF]
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Pulmonary and systemic arterial hypertension are associated with profound alterations in Ca2+ homeostasis and smooth muscle cell proliferation. A novel class of non-selective cation channels, the transient receptor potential (TRP) channels, have emerged ...
Yuan, Jason X.-J. +2 more
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Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2007 Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels have occupied an important place in the understanding of sensory nerve function in the context of pain.
Cortright, Daniel N. +2 more
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, 2023 Melanocortin receptors (MCRs) are a family of G protein-coupled receptors that regulate important physiological functions. Yet, drug development targeting MCRs is hindered by potential side effects due to a lack of receptor subtype-selective ligands with
Yang Zhou (65942) +4 more
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Neuron, 2005 Transient receptor potential (TRP) ion channels are molecular gateways in sensory systems, an interface between the environment and the nervous system. Several TRPs transduce thermal, chemical, and mechanical stimuli into inward currents, an essential first step for eliciting thermal and pain sensations.
Wang, Haibin, Woolf, Clifford J.
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Annual Review of Biochemistry, 2007 The TRP (Transient Receptor Potential) superfamily of cation channels is remarkable in that it displays greater diversity in activation mechanisms and selectivities than any other group of ion channels. The domain organizations of some TRP proteins are also unusual, as they consist of linked channel and enzyme domains.
Kartik, Venkatachalam, Craig, Montell
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Current Biology, 2008 In the last decade, studies of transient receptor potential (TRP) channels, a superfamily of cation-conducting membrane proteins, have significantly extended our knowledge about the molecular basis of sensory perception in animals. Due to their distinct activation mechanisms and biophysical properties, TRP channels are highly suited to function in ...
Damann, Nils +2 more
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TRP Channels in Digestive Tract Cancers. [PDF]
, 2020 Cancers of the digestive tract are among the most prevalent types of cancer. These types of cancers are often diagnosed at a late stage, which results in a poor prognosis.
Borgström, Anna +7 more
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Emergence of functional sensory subtypes as defined by transient receptor potential channel expression [PDF]
, 2007 The existence of heterogeneous populations of dorsal root ganglion (DRG) neurons conveying different somatosensory information is the basis for the perception of touch, temperature, and pain. A differential expression of transient receptor potential (TRP)
Hjerling-Leffler, J +4 more
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Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]
, 1994 The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Strasburger, Christian J. +14 more
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Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]
, 2010 The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov +18 more
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