Results 41 to 50 of about 176,809 (302)

The C‐terminal domain of yeast Arginyltransferase1 is essential for its catalytic activity

FEBS Open Bio, EarlyView.
Arginyltransferase 1 (Ate1), a eukaryotic enzyme, catalyses arginylation, transferring arginine from tRNA‐Arg to the amino terminus of the target protein. Overexpression of Ate1 in yeast is lethal and is dependent on arginylation. This study elucidates how mutations in the cofactor‐binding and active site of Ate1 and truncation of its structural ...
Vikas Kumar Yadav, Shweta Shweta, Manisha Malhotra, Vikash Maurya, Akhilesh Kumar   +4 more
wiley   +1 more source

Conformational Switching of Proteins on Material Surfaces Enabled by Peptide‐Oriented Adsorption

Advanced Functional Materials, EarlyView.
Responsive biointerfaces could be achieved using conformationally responsive proteins; however, their interconversion can be lost upon surface adsorption. Herein, we demonstrate that the incorporation a Au binding peptide into calmodulin allows for binding control on Au wherein the protein retains conformational switching. This capability was confirmed
Sakthirupini Ramamurthy, Kyle B. Meerbott, Lorenzo Travaglini, Garima S. Dobhal, Artur Sawicki, Marc R. Knecht, Tiffany R. Walsh, Dominic J. Glover   +7 more
wiley   +1 more source

A novel approach for the segmentation of retinal images by integration K-means clustering algorithm with graph cut for image segmentation

Scientific Reports
Diabetic retinopathy (DR) is a foremost cause of vision impairment, characterized by the presence of microaneurysms, exudates, and other intricate retinal lesions.
Ramasubramanian Bhoopalan, S. Priyadharshini   +1 more
doaj   +1 more source

AAV9-Mediated Overexpression of TRPM4 Increases the Incidence of Stress-Induced Ventricular Arrhythmias in Mice

Frontiers in Physiology, 2019
Ca2+ activated non-selective (CAN) cation channels have been described in cardiomyocytes since the advent of the patch clamp technique. It has been hypothesized that this type of ion channel contributes to the triggering of cardiac arrhythmias.
Andy Pironet, Ninda Syam, Frone Vandewiele, Chris Van den Haute, Sara Kerselaers, Silvia Pinto, Greetje Vande Velde, Rik Gijsbers, Rudi Vennekens   +8 more
doaj   +1 more source

TRP channels as biological sensors [PDF]

, 2008
TRP is the most recently discovered family of ion channels and display the largest structure and function diversity among ion channels. Most TRP channels are key elements in sensory cells, where they are involved in the response to a broad range of ...
Astorga, Guadalupe, Bacigalupo, Juan
core  

Gonadotropin‐Inhibitory Hormone (GnIH) and Its Receptor GPR147 Mediates Acute Stress‐Induced Activation of the Locus Coeruleus‐SAM Axis

Advanced Science, EarlyView.
ABSTRACT Gonadotropin‐inhibitory hormone (GnIH, also known as RFamide‐related peptide‐3, RFRP‐3) is a hypothalamic neuropeptide that regulates vertebrate reproduction via its receptor GPR147. Although GnIH is known to mediate stress‐induced reproductive suppression, its role in broader stress responses remains unclear.
Jiani Zhang, Hongyu Zhu, Wenqi Wang, Bingqian Shen, Yuanyuan Xin, Xingxing Song, Xuanyi Lu, Lixuan Li, Siting Chen, Xiaochen Zhang, Jialing Zeng, Haodong Zheng, Jianlong Lao, Ke Peng, Yixian Wei, Jiaming Zheng, Chuanhuo Hu, Xiaoye Wang, Xun Li   +18 more
wiley   +1 more source

High-precision non-destructive blade surface inspection via self learning transformer networks

Scientific Reports
Accurate identification of defects in Jet Engine Turbine and compressor blade surface plays a vital role in ensuring engine efficiency, safety and secure life.
Priyadharshini Kannusamy, D. Gayathri, S. Mirdula, Ramasubramanian Bhoopalan, D. Manikandan, Krishnaraj Ramaswamy   +5 more
doaj   +1 more source

TRP channels at a glance [PDF]

Journal of Cell Science, 2004
The t ransient r eceptor p otential (TRP) superfamily consists of a diverse set of proteins whose primary function is to regulate the plasma membrane permeability of animal cells to a variety of ions.
Raghu, Padinjat, Simon, Andrews
openaire   +2 more sources

Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte‐to‐DC Differentiation Via Microbiota‐Associated IAA

Advanced Science, EarlyView.
Lactiplantibacillus plantarum GUANKE remodels the indigenous gut microbiota and is associated with microbiota‐dependent restoration of circulating IAA. IAA treatment attenuates JAK3‐STAT3 and Jag1‐Notch4‐Hey1 signaling and reduces CX3CR1+Ly6C− monocytic precursor generation and pulmonary CD11b+ DC accumulation, together with reduced Th2 inflammation ...
Yujia He, Jielan Mi, Zhiping Zhao, Xiao Zhang, Zhihan Yang, Kun Yue, Yuanming Huang, Liqiong Song, Xiaoting Wen, Jianguo Xu, Zhihong Ren   +10 more
wiley   +1 more source

A self attention based deep learning framework for accurate and efficient dental disease detection in OPG radiographs

Scientific Reports
Oral diseases are increasing now-a-days and there is a high demand for the automatic diagnostic system that helps the clinician to detect these oral diseases with more accuracy and reduced human error.
Ramasubramanian Bhoopalan, S. Mirdula, Priyadharshini Kannusamy, D. Gayathri, D. Manikandan, Krishnaraj Ramaswamy   +5 more
doaj   +1 more source