Definition of two agonist types at the mammalian cold-activated channel TRPM8
eLife, 2016 Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood.
Annelies Janssens +8 more
doaj +1 more source
Very short peptides with stable folds: Building on the interrelationship of Trp/Trp, Trp/cation, and Trp/backbone–amide interaction geometries [PDF]
Proteins: Structure, Function, and Bioinformatics, 2008 AbstractBy combining a favorable turn sequence with a turn flanking Trp/Trp interaction and a C‐terminal H‐bonding interaction between a backbone amide and an i‐2 Trp ring, a particularly stable (ΔGU > 7 kJ/mol) truncated hairpin, Ac‐WI‐(D‐Pro‐D‐Asn)‐KWTG‐NH2, results.
Lisa, Eidenschink +3 more
openaire +2 more sources
Non-invasive skin sampling of tryptophan/kynurenine ratio in vitro towards a skin cancer biomarker
Scientific Reports, 2021 The tryptophan to kynurenine ratio (Trp/Kyn) has been proposed as a cancer biomarker. Non-invasive topical sampling of Trp/Kyn can therefore serve as a promising concept for skin cancer diagnostics.
Skaidre Jankovskaja +5 more
doaj +1 more source
Intestinal tryptophan metabolism in disease prevention and swine production
Animal Nutrition, 2023 Tryptophan (Trp) is an essential amino acid that cannot be synthesized by animals. It has been characterized into two different isomers, levorotation-Trp (L-Trp) and dextrorotation-Trp (D-Trp), based on their distinct molecule orientation.
Zhenguo Hu +6 more
doaj +1 more source
VAMP7 regulates constitutive membrane incorporation of the cold-activated channel TRPM8
Nature Communications, 2016 The temperature-sensitive TRPM8 channel is essential for cold sensing and has been linked to pathological cold hypersensitivity. Here, the authors find TRPM8 insertion in the cell membrane is mediated by VAMP7 following atypical LAMP1-containing vesicle ...
Debapriya Ghosh +12 more
doaj +1 more source
Screening of human tumor antigens for CD4 T cell epitopes by combination of HLA-transgenic mice, recombinant adenovirus and antigen peptide libraries. [PDF]
PLoS ONE, 2010 BACKGROUND: As tumor antigen-specific CD4+ T cells can mediate strong therapeutic anti-tumor responses in melanoma patients we set out to establish a comprehensive screening strategy for the identification of tumor-specific CD4+ T cell epitopes suitable ...
Wolfram Osen +9 more
doaj +1 more source
TRP-1 and TRP-2 are required for head steering locomotion.
, 2018 (A) Schematic of the SMD neurons in C. elegans and the values analyzed during forward movement. (B) A phylogenetic tree of the TRPC subfamily channels. (C) The genomic locations (above) and structures (below) of the trp-1 and trp-2 genes.
Jinmahn Kim (787021) +9 more
core +1 more source
Journal of Materials Research and Technology, 2019 Non-destructive testing is one part of the function of quality control and is complementary to other long-established methods. By definition, non-destructive testing is the testing of materials, for surface or internal flaws or metallurgical condition ...
A. Bovas Herbert Bejaxhin +2 more
doaj +1 more source
Mouse TRPA1 function and membrane localization are modulated by direct interactions with cholesterol
eLife, 2019 The cation channel TRPA1 transduces a myriad of noxious chemical stimuli into nociceptor electrical excitation and neuropeptide release, leading to pain and neurogenic inflammation.
Justyna B Startek +9 more
doaj +1 more source
TRP-1 and TRP-2 are stretch-sensitive proprioceptive receptors.
, 2018 (A) Heat maps and the average turning angle for indicated genotypes. n = 20 for each genotype. (B) Average wave width of the indicated genotypes. n = 50 for each genotype.
Jinmahn Kim (787021) +9 more
core +1 more source