Results 21 to 30 of about 164,112 (301)

Trp-rich sequence motifs in the gp41 region of Env. [PDF]

, 2019
The figure was generated using the AnalyzeAlign database of the Los Alamos National Laboratory (http://www.hiv.lanl.gov/) based on the curated alignment of 6636 sequences.
Mark Sullivan (459776), Mark E. Dumont (1640836), Hong Zhu (109912), Elizabeth Mathew (5870612), Jeffrey Zuber (1640839), James J. Kobie (7365761), Michael S. Piepenbrink (7365758), Sara M. Connelly (1640833)   +7 more
core   +1 more source

A Direct in Vivo Comparison of the Melanocortin Monovalent Agonist Ac-His-DPhe-Arg-Trp-NH₂ versus the Bivalent Agonist Ac-His-DPhe-Arg-Trp-PEDG20-His-DPhe-Arg-Trp-NH₂: A Bivalent Advantage [PDF]

, 2017
Bivalent ligands targeting putative melanocortin receptor dimers have been developed and characterized in vitro; however, studies of their functional in vivo effects have been limited.
Sathya M. Schnell (2574232), Katie T. Freeman (3644092), Stacey L. Wilber (2886779), Adam T. Zarth (1368882), Cody J. Lensing (2574229), Robert C. Speth (605293), Carrie Haskell-Luevano (1322436), Danielle N. Adank (2574226)   +7 more
core   +1 more source

Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]

, 1994
The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Strasburger, Christian J., Renner, U., Müller, O., Stalla, G., Brockmeier, S., Schopohl, Jochen, Strasburger, C., Müller, Otto-Albrecht, Schopohl, J., Strasburger, C. J., Werder, K., Lange, M., Werder, K. von, Stalla, G. K., Müller, O. A.   +14 more
core   +1 more source

Fluorine induced conformational switching and modulation in photophysical properties of 7-fluorotryptophan: Spectroscopic, quantum chemical calculation and molecular dynamics simulation studies

Journal of Photochemistry and Photobiology, 2020
7-Fluorotryptophan (7F-Trp) is an important noncanonical derivative of tryptophan (Trp) amino acid which depicts high in vivo stability for the positron emission tomography imaging of Trp metabolism.
Tonima Nandy, Saptarsi Mondal, Prashant Chandra Singh   +2 more
doaj   +1 more source

Drosophila TRPM channel is essential for the control of extracellular magnesium levels [PDF]

, 2010
The TRPM group of cation channels plays diverse roles ranging from sensory signaling to Mg2+ homeostasis. In most metazoan organisms the TRPM subfamily is comprised of multiple members, including eight in humans. However, the Drosophila TRPM subfamily is
Vladimir Chubanov, Craig Montell, Chen, Xiaodi, Xiaodi Chen, Anna S Dietz, Dietz, Anna S., Anna S. Dietz, Chubanov, Vladimir, Thomas Hofmann, Thomas Gudermann, Chen Xiaodi, Hofmann Thomas, Chubanov Vladimir, Dietz Anna S., Montell Craig, Gudermann, Thomas, Gudermann Thomas, Montell, Craig, Hofmann, Thomas   +18 more
core   +1 more source

Evaluation of tryptophan biomass as an alternative to conventional crystalline tryptophan in broiler diets

Journal of Applied Poultry Research, 2023
SUMMARY: The current experiment was conducted to evaluate tryptophan (Trp) biomass as an alternative to conventional crystalline Trp in broiler diets. In a growth trial, a total of 288 eight-day-old chicks were randomly allotted to 1 of 3 treatments with
J.H. Lee, C.H. Kwon, S.Y. Won, H.W. Kim, D.Y. Kil   +4 more
doaj   +1 more source

Definition of two agonist types at the mammalian cold-activated channel TRPM8

eLife, 2016
Various TRP channels act as polymodal sensors of thermal and chemical stimuli, but the mechanisms whereby chemical ligands impact on TRP channel gating are poorly understood.
Annelies Janssens, Maarten Gees, Balazs Istvan Toth, Debapriya Ghosh, Marie Mulier, Rudi Vennekens, Joris Vriens, Karel Talavera, Thomas Voets   +8 more
doaj   +1 more source

Very short peptides with stable folds: Building on the interrelationship of Trp/Trp, Trp/cation, and Trp/backbone–amide interaction geometries [PDF]

Proteins: Structure, Function, and Bioinformatics, 2008
AbstractBy combining a favorable turn sequence with a turn flanking Trp/Trp interaction and a C‐terminal H‐bonding interaction between a backbone amide and an i‐2 Trp ring, a particularly stable (ΔGU > 7 kJ/mol) truncated hairpin, Ac‐WI‐(D‐Pro‐D‐Asn)‐KWTG‐NH2, results.
Lisa, Eidenschink, Brandon L, Kier, Kelly N L, Huggins, Niels H, Andersen   +3 more
openaire   +2 more sources

Ac-Trp-DPhe(p-I)-Arg-Trp-NH₂, a 250-Fold Selective Melanocortin‑4 Receptor (MC4R) Antagonist over the Melanocortin‑3 Receptor (MC3R), Affects Energy Homeostasis in Male and Female Mice Differently [PDF]

, 2016
The melanocortin-4 receptor (MC4R) has been indicated as a therapeutic target for metabolic disorders such as anorexia, cachexia, and obesity. The current study investigates the in vivo effects on energy homeostasis of a 15 nM MC4R antagonist SKY2-23-7 ...
Stacey L. Wilber (2886779), Amy Andreasen (2886776), Zhimin Xiang (2719438), Cody J. Lensing (2574229), Carrie Haskell-Luevano (1322436), Jay W. Schaub (2886773), Danielle N. Adank (2574226), Skye R. Doering (1374147)   +7 more
core   +1 more source

Intestinal tryptophan metabolism in disease prevention and swine production

Animal Nutrition, 2023
Tryptophan (Trp) is an essential amino acid that cannot be synthesized by animals. It has been characterized into two different isomers, levorotation-Trp (L-Trp) and dextrorotation-Trp (D-Trp), based on their distinct molecule orientation.
Zhenguo Hu, Luya Feng, Qian Jiang, Wenliang Wang, Bi'e Tan, Xiongzhuo Tang, Yulong Yin   +6 more
doaj   +1 more source