Results 91 to 100 of about 163,766 (299)

SuFEx‐Enabled Reprogramming of Flavonoids for Selective α‐Glucosidase Covalent Inhibition

Advanced Science, EarlyView.
Selective inhibition of intestinal α‐glucosidase remains limited by poor enzyme specificity and off‐target metabolic effects. Here, SuFEx click chemistry is used to reprogram natural flavonoids into covalent inhibitors with enhanced α‐glucosidase selectivity and controlled reactivity. This strategy enables effective regulation of carbohydrate digestion
Fengyu Guo, Liwei Zhang, Minlong Wang, Yanjin Du, Tianyu Zhang, Hao Chen, Jiazeng Sun, Yang Yu, Zude He, Jie An, Xiaoxu Zhang, Weilin Lin, Fazheng Ren, Pengjie Wang, Ping Liu   +14 more
wiley   +1 more source

Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism

Frontiers in Cellular and Infection Microbiology, 2018
The gut microbiota influences the health of the host, especially with regard to gut immune homeostasis and the intestinal immune response. In addition to serving as a nutrient enhancer, L-tryptophan (Trp) plays crucial roles in the balance between ...
Jing Gao, Jing Gao, Jing Gao, Kang Xu, Kang Xu, Hongnan Liu, Hongnan Liu, Gang Liu, Gang Liu, Miaomiao Bai, Miaomiao Bai, Can Peng, Can Peng, Tiejun Li, Tiejun Li, Yulong Yin, Yulong Yin, Yulong Yin, Yulong Yin   +18 more
doaj   +1 more source

Putting the temporal resolution power (TRP) hypothesis to a critical test: Is the TRP-g relationship still more fundamental than an optimized relationship between speed of information processing and g?

, 2018
The present study investigated whether the relationship between temporal resolution power (TRP) and general intelligence (g) is more fundamental than the relationship between speed of information processing (SIP) and g when a) TRP and SIP are assessed ...
Pahud, Olivier, Rammsayer, Thomas H., Troche, Stefan J.   +2 more
core   +1 more source

Histone Modification Complex JMJ704‐HDA709 Negatively Regulates Salinity Tolerance in Rice

Advanced Science, EarlyView.
This study reveals that the rice histone demethylase JMJ704 interacts with HDA709―a H3K9ac deacetylase characterized herein―to form a chromatin‐modifying complex. Under salt stress, OsWRKY72 recruits this complex through interaction with JMJ704 to target loci, repressing the expression of oxidative stress and salt‐responsive genes via removal of ...
Jing Wang, Zhengting Chen, Pengxiang Bai, Biao Liu, Lingling Meng, Jian Zhang, Xu Li, Dao‐Xiu Zhou, Xuan Ma, Yu Zhao   +9 more
wiley   +1 more source

Activation of the kynurenine pathway is associated with poor outcome in Pneumocystis pneumonia patients infected with HIV: results of 2 months cohort study

BMC Infectious Diseases, 2019
Background Indoleamine 2, 3-dioxygenase (IDO) is a key enzyme in the degradation of tryptophan (Trp) to kynurenine (Kyn). We measured IDO activity as the Kyn to Trp ratio, and investigated whether IDO could be used to assess prognosis of acquired immune ...
Mengyan Wang, Xiaotian Dong, Ying Huang, Junwei Su, Xiahong Dai, Yongzheng Guo, Caiqin Hu, Qihui Zhou, Biao Zhu   +8 more
doaj   +1 more source

A TRP among the astrocytes

The Journal of Physiology, 2012
Abstract TRP channels were first identified as membrane proteins mediating phototransduction in fruit flies. Astrocytes were initially referred to as the silent elements of the nervous system. At the time these discoveries were made, few would have suspected TRP channels and astrocytes could contribute significantly to our understanding of brain ...
openaire   +3 more sources

TRP channels and pain

, 2007
Since the molecular identification of the capsaicin receptor, now known as TRPV1, transient receptor potential (TRP) channels have occupied an important place in the understanding of sensory nerve function in the context of pain.
Cortright, Daniel N., Broom, Daniel C., Krause, James E.   +2 more
core   +1 more source

A moderate inflammation caused by the deterioration of housing conditions modifies Trp metabolism but not Trp requirement for growth of post-weaned piglets

Animal, 2010
Deterioration of the environment in which piglets are housed after weaning induces a moderate inflammatory response and modifies tryptophan (Trp) metabolism that can, in turn, decrease Trp availability for growth.
N. Le Floc’h, J.J. Matte, D. Melchior, J. van Milgen, B. Sève   +4 more
doaj   +1 more source

Structure−Activity Relationships of the Melanocortin Tetrapeptide Ac-His-DPhe-Arg-Trp-NH₂ at the Mouse Melanocortin Receptors:  Part 2 Modifications at the Phe Position

, 2016
The melanocortin pathway is an important participant in skin pigmentation, steroidogenesis, obesity, energy homeostasis and exocrine gland function.
Jerry Ryan Holder (2401027), Rayna M. Bauzo (2684014), Zhimin Xiang (2719438), Carrie Haskell-Luevano (1322436)   +3 more
core   +1 more source

AI‐Designed Cyclic Peptides Enable Controllable Modulation of the CD28 Immune Checkpoint

Advanced Science, EarlyView.
AI‐designed cyclic peptides enable controllable modulation of the CD28 immune checkpoint through reversible disruption of CD28‐CD80/CD86 interactions. The lead peptide, CIP‐3, suppresses T‐cell activation without intrinsic agonist activity, demonstrates dose‐dependent efficacy in a murine colitis model, and attenuates inflammatory cytokine production ...
Katarzyna Kuncewicz, Saurabh Upadhyay, Renjie Zhu, Hongliang Duan, Moustafa T. Gabr   +4 more
wiley   +1 more source