Results 121 to 130 of about 176,809 (302)

Magnetic interactions in copper model systems Cu2+:Gly-Trp and Cu2+: Trp-Gly

, 2008
Derivados metálicos de aminoácidos são sistemas modelo simples para o estudo de íons metálicos em estruturas que simulam proteínas. O principal objetivo dessas investigações é avaliar as magnitudes dos parâmetros de acoplamento por interação de troca e ...
Costa Filho, Antonio José da
core   +1 more source

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Microbial modulation of tryptophan metabolism links gut microbiota to disease and its treatment

Pharmacological Research
Emerging studies have demonstrated that tryptophan (Trp) metabolism plays a critical role in maintaining intestinal and systemic homeostasis. Trp metabolism is involved in diseases such as metabolic syndrome, gastrointestinal cancers, neurological ...
Pengfei Zhao, Yuqi Chen, Shuyu Zhou, Fei Li   +3 more
doaj   +1 more source

TRP and TRPL channels in Drosophila visual system.

, 2012
Confocal immunofluorescence images of TRP and TRPL in wt brain slices. (A) Single confocal optical sections showing TRP distribution (red) in the retina (R) and lamina (L) detected with a monoclonal α-TRP antibody. Nuclei stained with TOPRO (blue) (left).
Magdalena Sanhueza (138259), Guadalupe Astorga (138251), Steffen Härtel (138256), Juan Bacigalupo (138263)   +3 more
core   +1 more source

Recurrent Neurodevelopmental Disorder Associated With a Dominant‐Negative TOP2B H63Y Variant

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT We describe a 7 year‐old boy with severe neurodevelopmental disorder, medically‐refractory epileptic encephalopathy, hyperkinetic movement disorder, hypotonia, cerebral and cerebellar atrophy and hypomyelination who was found to have a heterozygous de novo TOP2B NM_001330700.2:c.187C>T, p.(His63Tyr) variant.
Zong Yi Ha, Leticia Dinatto, Kirsten Meagher, Colleen Guimond, Jan M. Friedman, Peter C. Stirling, Millan S. Patel   +6 more
wiley   +1 more source

Effect of Tryptophan Supplementation Levels on the Cecal Microbial Composition, Growth Performance, Immune Function and Antioxidant Capacity in Broilers

Metabolites
Background: Tryptophan (Trp) is a limiting amino acid in poultry nutrition. Dietary supplementation of Trp not only enhances production performance, but also supports intestinal barrier integrity, alleviates stress, and boosts immunity, in which the ...
Xuelan Liu, Chunyan Fu, Qingtao Gao, Heng Zhang, Tianhong Shi, Guiming Li, Yunchao Wang, Yan Shang   +7 more
doaj   +1 more source

The Role of Glutamatergic and Dopaminergic Genes in Resistant Schizophrenia: A Systematic Review

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Psychosis is a heterogeneous disorder, with approximately one‐third of patients experiencing treatment resistance, predominantly among individuals diagnosed with Schizophrenia. Treatment‐resistant schizophrenia (TRS) may stem from a distinct biological signature, involving abnormalities in the dopaminergic and glutamatergic systems.
Maria Teresa Moreno‐Calle, Silvia Iñiguez‐Barrio, Maria Aurora Arrue, Leire Erkoreka   +3 more
wiley   +1 more source

TRP Is Cracked but Is CRAC TRP? [PDF]

Neuron, 1996
openaire   +2 more sources

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

Transition-Relevance Place (TRP)

The notion of a transition-relevance place (TRP) was introduced by Sacks, Schegloff and Jefferson (1974) to explain how a current speaker and a next speaker coordinate turn-transitions in an orderly manner.
Shimako Iwasaki
core   +1 more source