Results 261 to 270 of about 1,264,013 (289)
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2010
Ion channels and notably TRP channels play a crucial role in a variety of physiological functions and in addition these channels have been also shown associated with several diseases including cancer. The process of cancer initiation and progression involves the altered expression of one or more of TRP proteins, depending on the nature of the cancer ...
Lehen’kyi, V’yacheslav +1 more
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Ion channels and notably TRP channels play a crucial role in a variety of physiological functions and in addition these channels have been also shown associated with several diseases including cancer. The process of cancer initiation and progression involves the altered expression of one or more of TRP proteins, depending on the nature of the cancer ...
Lehen’kyi, V’yacheslav +1 more
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Thermosensation and TRP Channels
Somatosensory neurons can sense external temperature by converting sensation of temperature information to neural activity via afferent input to the central nervous system. Various populations of somatosensory neurons have specialized gene expression, including expression of thermosensitive transient receptor potential (TRP) ion channels ...Makoto, Tominaga, Makiko, Kashio
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Endogenous Modulators of TRP Channels
Current Topics in Medicinal Chemistry, 2013The transient receptor potential (TRP) superfamily consists of a large number of cation channels permeable to both monovalent and divalent cations. The 28 mammalian TRP channels can be divided into seven subfamilies: the TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPP (polycystin), TRPML (mucolipin), TRPN (no mechanopotential, NOMP) and the
PALAZZO, Enza +3 more
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Pflügers Archiv - European Journal of Physiology, 2005
The transient receptor potential (TRP) superfamily comprises a large group of related cation channels that display surprising diversity in the specific modes of activation and cation selectivities. However, a unifying theme is that many TRP channels play important roles in sensory physiology.
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The transient receptor potential (TRP) superfamily comprises a large group of related cation channels that display surprising diversity in the specific modes of activation and cation selectivities. However, a unifying theme is that many TRP channels play important roles in sensory physiology.
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2010
In the normal human body pancreatic β-cells spend most of the time in a READY mode rather than in an OFF mode. When in the READY mode, normal β-cells can be easily SWITCHED ON by a variety of apparently trivial stimuli. In the READY mode β-cells are highly excitable because of their high input resistance.
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In the normal human body pancreatic β-cells spend most of the time in a READY mode rather than in an OFF mode. When in the READY mode, normal β-cells can be easily SWITCHED ON by a variety of apparently trivial stimuli. In the READY mode β-cells are highly excitable because of their high input resistance.
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2007
Pain is initiated when noxious stimuli excite the peripheral terminals of specialized primary afferent neurons called nociceptors. Many molecules are involved in conversion of the noxious stimuli to the electrical signals in the nociceptor endings. Among them, TRP channels play important roles in detecting noxious stimuli.
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Pain is initiated when noxious stimuli excite the peripheral terminals of specialized primary afferent neurons called nociceptors. Many molecules are involved in conversion of the noxious stimuli to the electrical signals in the nociceptor endings. Among them, TRP channels play important roles in detecting noxious stimuli.
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Advances in TRP channel drug discovery: from target validation to clinical studies
Nature Reviews Drug Discovery, 2021Arpad Szallasi +2 more
exaly
The light-activated TRP channel: the founding member of the TRP channel superfamily
Journal of Neurogenetics, 2022William L Pak
exaly
Proceedings of the National Academy of Sciences of the United States of America, 2015
Andriy Anishkin +2 more
exaly
Andriy Anishkin +2 more
exaly
Pregnenolone Sulfate: From Steroid Metabolite to TRP Channel Ligand
Molecules, 2013Christian Harteneck
exaly