Results 91 to 100 of about 14,118 (233)

TrpA1 Regulates Thermal Nociception in Drosophila

PLoS ONE, 2011
Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger. To prevent damage the systems that detect noxious stimuli are therefore under strict evolutionary pressure.
Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM   +10 more
openaire   +4 more sources

Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?

Pharmaceuticals, 2016
Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is expressed abundantly on the C fibers that innervate almost entire respiratory tract starting from oral cavity and oropharynx, conducting airways in the trachea, bronchi, terminal bronchioles ...
Indranil Mukhopadhyay, Abhay Kulkarni, Neelima Khairatkar-Joshi   +2 more
doaj   +1 more source

Hypotonicity-induced cell swelling activates TRPA1

The Journal of Physiological Sciences, 2018
Hypotonic solutions can cause painful sensations in nasal and ocular mucosa through molecular mechanisms that are not entirely understood. We clarified the ability of human TRPA1 (hTRPA1) to respond to physical stimulus, and evaluated the response of hTRPA1 to cell swelling under hypotonic conditions.
Fujita, Fumitaka, Uchida, Kunitoshi, Takayama, Yasunori, Suzuki, Yoshiro, Takaishi, Masayuki, Tominaga, Makoto   +5 more
openaire   +2 more sources

The Contact Allergen Methylisothiazolinone (MIT) is a Potent Activator of the TRPA1 Ion Channel

Pharmacology Research & Perspectives
Methylisothiazolinone (MIT) is a known inducer of allergic contact dermatitis that is used as a preservative and a biocide in consumer products. Transient receptor potential ankyrin 1 (TRPA1) is a non‐selective cation channel expressed in neurons and in ...
Ilari Mäki‐Opas, Samu Luostarinen, Mari Hämäläinen, Katsuhiko Muraki, Eeva Moilanen   +4 more
doaj   +1 more source

TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in miceResearch in context

EBioMedicine, 2018
Background: Recent evidence has indicated that the transient receptor potential ankyrin 1 (TRPA1) is expressed in the cardiovascular system and implicated in the development and progression of several cardiovascular diseases.
Zhen Wang, Yao Xu, Menglong Wang, Jing Ye, Jianfang Liu, Huimin Jiang, Di Ye, Jun Wan   +7 more
doaj   +1 more source

Endothelium-Dependent Cerebral Artery Dilation Mediated by TRPA1 and Ca ²⁺ -Activated K ⁺ Channels [PDF]

, 2009
Scott Earley, Albert L. Gonzales, Rachael Crnich   +2 more
openalex   +1 more source

Brain endothelial cell TRPA1 channels initiate neurovascular coupling

, 2021
Pratish Thakore, Michael G. Alvarado, Sher Ali, Amreen Mughal, Paulo W. Pires, Evan Yamasaki, Harry A. T. Pritchard, Brant E. Isakson, Cam Ha T. Tran, Scott Earley   +9 more
openalex   +1 more source

Investigation of Cuprizone-Induced Demyelination in mGFAP-Driven Conditional Transient Receptor Potential Ankyrin 1 (TRPA1) Receptor Knockout Mice

Cells, 2019
Transient receptor potential ankyrin 1 (TRPA1) receptors are non-selective cation channels responsive to a variety of exogenous irritants and endogenous stimuli including products of oxidative stress.
Gábor Kriszta, Balázs Nemes, Zoltán Sándor, Péter Ács, Sámuel Komoly, Zoltán Berente, Kata Bölcskei, Erika Pintér   +7 more
doaj   +1 more source

TRPA1 induced in sensory neurons contributes to cold hyperalgesia after inflammation and nerve injury [PDF]

, 2010
Koichi Obata, Hirokazu Katsura, Toshiyuki Mizushima, Hiroki Yamanaka, Kimiko Kobayashi, Yi Dai, Tetsuo Fukuoka, Atsushi Tokunaga, Makoto Tominaga, Koichi Noguchi   +9 more
openalex   +1 more source

Spatial and temporal coordination of Duox/TrpA1/Dh31 and IMD pathways is required for the efficient elimination of pathogenic bacteria in the intestine of Drosophila larvae

eLife
Multiple gut antimicrobial mechanisms are coordinated in space and time to efficiently fight foodborne pathogens. In Drosophila melanogaster, production of reactive oxygen species (ROS) and antimicrobial peptides (AMPs) together with intestinal cell ...
Fatima Tleiss, Martina Montanari, Romane Milleville, Olivier Pierre, Julien Royet, Dani Osman, Armel Gallet, C Leopold Kurz   +7 more
doaj   +1 more source