Results 91 to 100 of about 11,892 (197)

Roux-en-Y gastric bypass enhances insulin secretion in type 2 diabetes via FXR-mediated TRPA1 expression

Molecular Metabolism, 2019
Objective: Roux-en-Y gastric bypass surgery (RYGB) improves the first phase of glucose-stimulated insulin secretion (GSIS) in patients with type 2 diabetes. How it does so remains unclear.
Xiangchen Kong, Yifan Tu, Bingfeng Li, Longmei Zhang, Linxian Feng, Lixiang Wang, Lin Zhang, Huarong Zhou, Xianxin Hua, Xiaosong Ma   +9 more
doaj   +1 more source

Mechanosensitive Ion Channel PIEZO1 Suppresses BMP2‐Induced Ossification of the Annulus Fibrosus Cells

JOR SPINE, Volume 9, Issue 1, March 2026.
This study aimed to elucidate the function of PIEZO1in AF cells under mechanical stimulation. Low‐magnitude cyclictensile strain (CTS, 2%) suppressed osteogenic marker expression. Pharmacological activation of PIEZO1 using Yoda1 mimics the effects oflow‐strain CTS.
Hisakazu Shitozawa, Ryo Nakamichi, Aki Yoshida, Masataka Ueda, Taichi Saito, Koji Uotani, Yoshiaki Oda, Ryo Takatori, Kazutaka Yamashita, Toshifumi Ozaki   +9 more
wiley   +1 more source

TrpA1 Regulates Thermal Nociception in Drosophila

PLoS ONE, 2011
Pain is a significant medical concern and represents a major unmet clinical need. The ability to perceive and react to tissue-damaging stimuli is essential in order to maintain bodily integrity in the face of environmental danger. To prevent damage the systems that detect noxious stimuli are therefore under strict evolutionary pressure.
Neely GG, Keene AC, Duchek P, Chang EC, Wang QP, Aksoy YA, Rosenzweig M, Costigan M, Woolf CJ, Garrity PA, Penninger JM   +10 more
openaire   +4 more sources

TRPA1 Ion Channel Determines Beneficial and Detrimental Effects of GYY4137 in Murine Serum-Transfer Arthritis

Frontiers in Pharmacology, 2019
Modulation of nociception and inflammation by sulfide in rheumatoid arthritis and activation of transient receptor potential ankyrin 1 (TRPA1) ion channels by sulfide compounds are well documented.
István Z. Bátai, Cecília Pápainé Sár, Ádám Horváth, Éva Borbély, Kata Bölcskei, Ágnes Kemény, Ágnes Kemény, Zoltán Sándor, Balázs Nemes, Zsuzsanna Helyes, Anikó Perkecz, Attila Mócsai, Attila Mócsai, Gábor Pozsgai, Erika Pintér   +14 more
doaj   +1 more source

Hypotonicity-induced cell swelling activates TRPA1

The Journal of Physiological Sciences, 2018
Hypotonic solutions can cause painful sensations in nasal and ocular mucosa through molecular mechanisms that are not entirely understood. We clarified the ability of human TRPA1 (hTRPA1) to respond to physical stimulus, and evaluated the response of hTRPA1 to cell swelling under hypotonic conditions.
Fujita, Fumitaka, Uchida, Kunitoshi, Takayama, Yasunori, Suzuki, Yoshiro, Takaishi, Masayuki, Tominaga, Makoto   +5 more
openaire   +2 more sources

Blocking TRPA1 in Respiratory Disorders: Does It Hold a Promise?

Pharmaceuticals, 2016
Transient Receptor Potential Ankyrin 1 (TRPA1) ion channel is expressed abundantly on the C fibers that innervate almost entire respiratory tract starting from oral cavity and oropharynx, conducting airways in the trachea, bronchi, terminal bronchioles ...
Indranil Mukhopadhyay, Abhay Kulkarni, Neelima Khairatkar-Joshi   +2 more
doaj   +1 more source

Dermal Fibroblasts, Not Keratinocytes, Dominate IL‐17A/TNF‐Driven Inflammation

Experimental Dermatology, Volume 35, Issue 3, March 2026.
ABSTRACT Chronic inflammatory skin diseases such as psoriasis and hidradenitis suppurativa are driven by cytokines, including IL‐17A and TNF. Although biologics targeting these cytokines have transformed therapy, the transcriptional contributions of individual skin‐resident cell types remain unclear, and dermal fibroblasts have been largely overlooked ...
Lejla Svraka, Hakim Ben Abdallah, Trine Bertelsen, Christian Vestergaard, Claus Johansen   +4 more
wiley   +1 more source

TRPM3 activation causes CGRP release in trigeminal neurons: Implications for migraine mechanisms

Headache: The Journal of Head and Face Pain, Volume 66, Issue 3, Page 672-687, March 2026.
Abstract Background The transient receptor potential melastatin 3 (TRPM3) ion channel has been implicated in sensory modulation and pain transmission and may contribute to migraine pathophysiology through calcitonin gene‐related peptide (CGRP) release in the trigeminovascular system. This study aimed to investigate TRPM3 activation and its role in CGRP
Philip V. Reducha, Lukas K. S. Nielsen, Mette N. Jensen, Jacob C. A. Edvinsson, Spyridoula Kazantzi, Sofia L. Wæver, Tanja Lylloff, Connar S. J. Westgate, Lars Edvinsson, Kristian A. Haanes   +9 more
wiley   +1 more source

The exposomal imprint on rosacea: More than skin deep

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 387-403, March 2026.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki, Daniella Bakoli Sgourou, Alexandros Maniatis, Efstathia Pasmatzi   +3 more
wiley   +1 more source

The Contact Allergen Methylisothiazolinone (MIT) is a Potent Activator of the TRPA1 Ion Channel

Pharmacology Research & Perspectives
Methylisothiazolinone (MIT) is a known inducer of allergic contact dermatitis that is used as a preservative and a biocide in consumer products. Transient receptor potential ankyrin 1 (TRPA1) is a non‐selective cation channel expressed in neurons and in ...
Ilari Mäki‐Opas, Samu Luostarinen, Mari Hämäläinen, Katsuhiko Muraki, Eeva Moilanen   +4 more
doaj   +1 more source