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TRPA1 gene variants hurting our feelings
Pflügers Archiv - European Journal of Physiology, 2020TRPA1 is a Ca2+-permeable, non-selective cation channel that is activated by thermal and mechanical stimuli, an amazing variety of potentially noxious chemicals, and by endogenous molecules that signal tissue injury. The expression of this channel in nociceptive neurons and epithelial cells puts it at the first line of defense and makes it a key ...
Robbe Naert +3 more
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2019
Der „Transient Receptor Potential Ankyrin 1“ (TRPA1) Kanal zeichnet sich als Mitglied der TRP-Familie durch eine größere Zahl an sog. „Ankyrin-Repeats“ im Aminoterminus aus. Ansonsten besitzt er wie alle anderen TRP-Kanäle intrazelluläre Termini und sechs Transmembrandomänen mit einem Poren-bildenden Bereich zwischen der Domäne fünf und sechs.
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Der „Transient Receptor Potential Ankyrin 1“ (TRPA1) Kanal zeichnet sich als Mitglied der TRP-Familie durch eine größere Zahl an sog. „Ankyrin-Repeats“ im Aminoterminus aus. Ansonsten besitzt er wie alle anderen TRP-Kanäle intrazelluläre Termini und sechs Transmembrandomänen mit einem Poren-bildenden Bereich zwischen der Domäne fünf und sechs.
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Intracellular zinc irritates TRPA1
Nature Chemical Biology, 2009Exposure to zinc can cause pain and inflammation and can be harmful to human health. New evidence suggests that activation of the irritant receptor, TRPA1, which is expressed on pain-sensing neurons, may be responsible for some of these symptoms of zinc toxicity.
Banke, Tue G, Wickenden, Alan D
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NPPB structure-specifically activates TRPA1 channels
Biochemical Pharmacology, 2010TRPA1 channels have been found to play an important role in mammalian pain sensation, especially when the pain is caused by chemicals on site of inflammation. A large number of structurally diverse chemicals are found to activate TRPA1 channels, implicating a potential chemosensor in neuronal nociception.
Kun, Liu +4 more
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Cold sensitivity of recombinant TRPA1 channels
Brain Research, 2007TRPM8 and TRPA1, members of the transient receptor potential (TRP) channel family, are candidates for cooling-activated receptors. It is accepted that TRPM8 responds to moderate cooling, although it is controversial whether TRPA1 responds to deep cooling.
Yosuke, Sawada +4 more
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Imaging agent of a TRPA1 inhibitor
Journal of Labelled Compounds and Radiopharmaceuticals, 2013A method for the preparation of [3′‐3H]‐4‐(2′‐chloro‐6′‐hydroxyphenyl)‐2‐thioxo‐3,4‐dihydro‐1H‐indeno[1,2‐d]pyrimidin‐5(2H)‐one (1), a TRPA1 inhibitor, was developed for the evaluation of imaging properties of a class of TRPA1 inhibitors. 1 was prepared via tritiation of a protected benzaldehyde followed by a tetrachlorosilane catalyzed multicomponent ...
Jonas, Malmquist +2 more
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Skin- and airway-deliverable TRPA1 inhibitor
Bioorganic & Medicinal ChemistryThis study explored the potential of perfumery compounds as sources of transient receptor potential ankyrin 1 (TRPA1) inhibitors that could be formulated for effective delivery to the skin and airways. A highly potent, small, and selective TRPA1 inhibitor, 2-methyl-4-phenyl-1-pentanol (1), was discovered in perfumery compounds.
Tomohiro Shirai +5 more
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Sustained TRPA1 activation in vivo
Acta Physiologica, 2011AbstractTransient receptor potential A1 (TRPA1) is a calcium permeable non‐selective cation channel that is selectively localized to peptidergic C‐fibres in the pain pathway. TRPA1 is highly conserved across the animal kingdom and it is able to detect a wide range of potentially toxic environmental chemicals.
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