Results 51 to 60 of about 11,892 (197)
The Impact of Environmental Pollution and Climate Change on Allergic Rhinitis and Lung Diseases
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Environmental pollution and climate change seriously affect human health, leading to the onset and exacerbation of chronic respiratory diseases, such as allergic rhinitis and lung diseases. Over the past several decades, increasing air pollution and environmental exposure owing to global urbanization, industrialization, and rapid economic ...
Xin‐Yan Liu +4 more
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Research Progress on Upper Airway Cough Syndrome
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Upper airway cough syndrome (UACS) has been identified as a significant contributor to chronic cough in various national guidelines. However, the complexity of its pathogenesis, the lack of clarity surrounding its diagnostic criteria, and its overlap with other etiologies of chronic cough present considerable challenges in both diagnosis and ...
Wan‐Ting Huang, Jia Chen
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Frontiers in Physiology, 2016 The transient receptor potential cation channel, subfamily A, member 1 (TRPA1) is conserved between many arthropods, and in some has been shown to function as a chemosensor for noxious compounds.
Guangda Peng +5 more
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Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
TRPA1 modulators in preclinical development
Expert Opinion on Therapeutic Patents, 2009 Transient receptor potential ankyrin 1 (TRPA1) has been revealed as a pivotal molecular entity in sensory biology, especially as a sensor of chemical irritants present in foods, atmospheric pollutants and neurotoxic compounds. In addition, this channel appears responsible for detecting physical signals such as noxious cold and mechanical forces.There ...
Viana, Félix, Ferrer-Montiel, Antonio
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British Journal of Pharmacology, EarlyView.Abstract Background and Purpose Chemotherapy‐induced peripheral neuropathy (CIPN) is a prevalent and treatment‐resistant side effect of platinum‐based chemotherapy, characterised by mechanical allodynia. Cannabigerol (CBG), a non‐psychoactive cannabinoid, has shown antinociceptive potential, but its site and mechanism of action remain unclear.
Quinn W. Wade +7 more
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TRPA1 channels in the vasculature [PDF]
British Journal of Pharmacology, 2012 This review is focused on the role of the ankyrin (A) transient receptor potential (TRP) channel TRPA1 in vascular regulation. TRPA1 is activated by environmental irritants, pungent compounds found in foods such as garlic, mustard and cinnamon, as well as metabolites produced during oxidative stress. The structure of the channel is distinguished by the
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Cancer Science, EarlyView.Small cell lung cancer (SCLC) actively exports ATP through PANX1 channels, triggering P2RX7‐mediated autocrine signaling and promoting tumor proliferation. Inhibition of PANX1 or P2RX7 disrupts this loop and suppresses tumor growth. ABSTRACT Small cell lung cancer (SCLC) is an aggressive malignancy with a 5‐year survival rate of less than 7%.
Takeshi Tsuruda +2 more
wiley +1 more source
TRPA1 is a polyunsaturated fatty acid sensor in mammals.
PLoS ONE, 2012 Fatty acids can act as important signaling molecules regulating diverse physiological processes. Our understanding, however, of fatty acid signaling mechanisms and receptor targets remains incomplete.
Arianne L Motter, Gerard P Ahern
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The TRPA1 Channel Amplifies the Oxidative Stress Signal in Melanoma
Cells, 2021 Macrophages (MΦs) and reactive oxygen species (ROS) are implicated in carcinogenesis. The oxidative stress sensor, transient receptor potential ankyrin 1 (TRPA1), activated by ROS, appears to contribute to lung and breast cancer progression.
Francesco De Logu +11 more
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