Results 191 to 200 of about 9,278 (208)

TRPC1: a core component of store-operated calcium channels

Biochemical Society Transactions, 2007
The TRPC (transient receptor potential canonical) proteins are activated in response to agonist-stimulated PIP2 (phosphatidylinositol 4,5-bisphosphate) hydrolysis and have been suggested as candidate components of the elusive SOC (store-operated calcium channel). TRPC1 is currently the strongest candidate component of SOC.
openaire   +2 more sources

Cryo-EM structure of the heteromeric TRPC1/TRPC4 channel

Nature Structural & Molecular Biology
Transient receptor potential (TRP) ion channels have a crucial role as cellular sensors, mediating diverse physical and chemical stimuli. The formation of heteromeric structures expands the functionality of TRP channels; however, their molecular architecture remains largely unknown.
Jongdae Won, Jinhyeong Kim, Jinsung Kim, Juyeon Ko, Christine Haewon Park, Byeongseok Jeong, Sang-Eun Lee, Hyeongseop Jeong, Sun-Hong Kim, Hyunwoo Park, Insuk So, Hyung Ho Lee   +11 more
openaire   +2 more sources

TRPC1/4 heteromeric channel's current characteristic is unaffected by mutations in TRPC1 residues lining the pore region

Biophysical Journal, 2022
Christine Haewon Park, Jinsung Kim, Insuk So   +2 more
openaire   +1 more source

Function of the Porcine TRPC1 Gene in Myogenesis and Muscle Growth

Cells, 2021
, Ran Zhang
exaly  

TRPC1 inhibits the proliferation and migration of estrogen receptor-positive Breast cancer and gives a better prognosis by inhibiting the PI3K/AKT pathway

Breast Cancer Research and Treatment, 2020
Xiao-Long Wei
exaly  

Homer Binds TRPC Family Channels and Is Required for Gating of TRPC1 by IP3 Receptors

Cell, 2003
Kirill Kiselyov, Shin H Kang, Shmuel Muallem   +2 more
exaly  

Activation of the TRPC1 cation channel by metabotropic glutamate receptor mGluR1

Nature, 2003
Sang Jeong Kim, David J Linden
exaly  

Pressure-induced and store-operated cation influx in vascular smooth muscle cells is independent of TRPC1

Pflugers Archiv European Journal of Physiology, 2007
Alexander Dietrich, Galyna Dubrovska, Maik Gollasch   +2 more
exaly  

Calmodulin Regulates Ca2+-Dependent Feedback Inhibition of Store-Operated Ca2+ Influx by Interaction with a Site in the C Terminus of TrpC1

Molecular Cell, 2002
Xibao Liu, Indu S Ambudkar
exaly  

TRPC1 and TRPC5 Form a Novel Cation Channel in Mammalian Brain

Neuron, 2001
David E Clapham
exaly