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Function of TRPC1 in modulating hepatocellular carcinoma progression
Medical Oncology, 2023The liver is the main organ of metabolism in the human body, and it is easy to suffer from hepatitis, cirrhosis, liver cancer, and other diseases, the most serious of which is liver cancer. Worldwide, liver cancer is the most common and deadly malignant tumor, the third leading cause of cancer death in the world.
Huimin Qi, Fengming Wu, Hongmei Wang
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2014
The TRPC1 ion channel was the first mammalian TRP channel to be cloned. In humans, it is encoded by the TRPC1 gene located in chromosome 3. The protein is predicted to consist of six transmembrane segments with the N- and C-termini located in the cytoplasm.
Vasyl, Nesin, Leonidas, Tsiokas
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The TRPC1 ion channel was the first mammalian TRP channel to be cloned. In humans, it is encoded by the TRPC1 gene located in chromosome 3. The protein is predicted to consist of six transmembrane segments with the N- and C-termini located in the cytoplasm.
Vasyl, Nesin, Leonidas, Tsiokas
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TRPC1 and ORAI1 channels in colon cancer
Cell Calcium, 2019Colon cancer cells, like other types of cancer cells, undergo the remodeling of the intracellular Ca2+ homeostasis that contributes to cancer cell hallmarks including enhanced cell proliferation, migration, and survival. Colon cancer cells display enhanced store-operated Ca2+ entry (SOCE) compared with their non-cancer counterparts.
Villalobos, Carlos +3 more
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TRPC1 as a negative regulator for TRPC4 and TRPC5 channels
Pflügers Archiv - European Journal of Physiology, 2019Transient receptor potential canonical (TRPC) channels are calcium permeable, non-selective cation channels with wide tissue-specific distribution. Among 7 TRPC channels, TRPC 1/4/5 and TRPC3/6/7 are subdivided based on amino acid sequence homology.
Jinsung Kim +5 more
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Obligatory role for PKCδ in PIP2‐mediated activation of store‐operated TRPC1 channels in vascular smooth muscle cells [PDF]
Journal of Physiology, 2020 KEY POINTS: In vascular smooth muscle cells (VSMCs), activation of Ca2+ -permeable store-operated channels (SOCs) composed of canonical transient receptor potential channel 1 (TRPC1) subunits mediate Ca2+ entry pathways which regulate contraction ...
MIGUEL Martin-Aragon Baudel +2 more
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TRPC1 store-operated cationic channel subunit
Cell Calcium, 2003TRPC1 is a membrane protein that is highly conserved in mammals, amphibians and birds. It is widely expressed in cells throughout the body including in the heart and nervous system. Amino acid sequence analysis and over-expression studies indicate it is an ion channel that allows the transmembrane flux of small cations including sodium and calcium.
D J, Beech +3 more
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TRPC1: store-operated channel and more
Pflügers Archiv - European Journal of Physiology, 2005Transient receptor potential canonical 1 (TRPC1) is a transmembrane protein expressed in a range of vertebrate cells including smooth muscle, endothelium, neurones and salivary gland cells. It functions as an element of a mixed cationic Ca(2+)-permeable channel, probably commonly as part of a heterotetrameric assembly involving other related proteins ...
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Cell Calcium, 2008
While the role of members from the TRPC family of channels as receptor-operated channels (ROC) is well established and supported by numerous studies, the role of this family of channels as store-operated channels (SOC) has been the focus of a heated controversy over the last few years.
Sampieri, Alicia +4 more
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While the role of members from the TRPC family of channels as receptor-operated channels (ROC) is well established and supported by numerous studies, the role of this family of channels as store-operated channels (SOC) has been the focus of a heated controversy over the last few years.
Sampieri, Alicia +4 more
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TRPC1 is required for directed cell migration
The FASEB Journal, 2008Lamellipodial protrusion and directed cell migration depends on cellular asymmetry and the arrangement of forces generated in different regions of the cell. Fine‐tuned cytosolic Ca 2+ signals that are critical for coordinating theses forces originate among others from stretch‐activated Ca
Anke Fabian +6 more
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A mechanically activated TRPC1-like current in white adipocytes
Biochemical and Biophysical Research Communications, 2018Ca2+ impacts a large array of cellular processes in every known cell type. In the white adipocyte, Ca2+ is involved in regulation of metabolic processes such as lipolysis, glucose uptake and hormone secretion. Although the importance of Ca2+ in control of white adipocyte function is clear, knowledge is still lacking regarding the control of dynamic Ca2+
Mickaël F, El Hachmane +1 more
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