Results 171 to 180 of about 9,278 (208)

TRP channels and breast cancer: the role of TRPs in the pathophysiological development. [PDF]

Front Mol Biosci
Zhang Y, Yi Y, Shu Y, Ru X, He S.
europepmc   +1 more source

Hypergravity Enhances Stretch Sensitivity in Rat Cardiomyocytes via Increased Expression and Activity of Stretch-Activated Channels. [PDF]

Int J Mol Sci
Kamkin AG, Zolotarev VI, Kamkina O, Mitrokhin VM, Kazansky VE, Bilichenko A, Rodina AS, Zolotareva AD, Mladenov M.   +8 more
europepmc   +1 more source

The mutual interaction of TRPC5 channel with polycystin proteins. [PDF]

Korean J Physiol Pharmacol
Kwak M, Kang H, Kim J, Hong Y, Jeong B, Myeong J, So I.   +6 more
europepmc   +1 more source

(-)-Englerin A binds a conserved lipid site of TRPC5 and exposes a Met-aromatic motif in channel activation

Porav SA, Ptakova A, Bauer CC, Hammond KLR, Beech DJ, Vlachova V, Muench SP, Bon RS.   +7 more
europepmc   +1 more source

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TRPC1 exacerbate metastasis in gastric cancer via ciRS-7/miR-135a-5p/TRPC1 axis

Biochemical and Biophysical Research Communications, 2020
Metastasis is frequently occurred in end-stage GC. Nevertheless, the initiation and progression of metastasis in GC remains unclear. The transient receptor potential canonical (TRPC) has been confirmed to be crucial for metastasis in many kinds of tumors, including GC. However, the molecular mechanisms regulating TRPC1 is unclear.
Zhiyong, Zhang, Li, Ren, Qian, Zhao, Guifang, Lu, Mudan, Ren, Xinlan, Lu, Yan, Yin, Shuixiang, He, Cailin, Zhu   +8 more
exaly   +3 more sources

TRPC1: The housekeeper of the hippocampus

Cell Calcium
The non-selective cation channel TRPC1 is highly expressed in the brain. Recent research shows that neuronal TRPC1 forms heteromeric complexes with TRPC4 and TRPC5, with a small portion existing as homotetramers, primarily in the ER. Given that most studies have focused on the role of heteromeric TRPC1/4/5 complexes, it is crucial to investigate the ...
Thomas Stockner, Klaus Groschner, Oleksandra Tiapko   +2 more
exaly   +3 more sources

Function of TRPC1 in modulating hepatocellular carcinoma progression

Medical Oncology, 2023
The liver is the main organ of metabolism in the human body, and it is easy to suffer from hepatitis, cirrhosis, liver cancer, and other diseases, the most serious of which is liver cancer. Worldwide, liver cancer is the most common and deadly malignant tumor, the third leading cause of cancer death in the world.
Huimin Qi, Fengming Wu, Hongmei Wang
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TRPC1 Is Essential for In Vivo Angiogenesis in Zebrafish [PDF]

Circulation Research, 2010
Rationale : Wiring vascular and neural networks are known to share common molecular signaling pathways. Activation of transient receptor potential type C channels (TRPCs) has recently been shown to
Jiu-lin Du
exaly   +3 more sources

TRPC1 channels regulate directionality of migrating cells [PDF]

Pflugers Archiv European Journal of Physiology, 2008
Cell migration depends on the generation of structural asymmetry and on different steps: protrusion and adhesion at the front and traction and detachment at the rear part of the cell. The activity of Ca(2+) channels coordinate these steps by arranging intracellular Ca(2+) signals along the axis of movement.
Fabian, A., Fortmann, T., Dieterich, P., Riethmueller, C., Schoen, P., Mally, S., Nilius, Bernd, Schwab, A.   +7 more
exaly   +3 more sources

TRPC1 store-operated cationic channel subunit

Cell Calcium, 2003
TRPC1 is a membrane protein that is highly conserved in mammals, amphibians and birds. It is widely expressed in cells throughout the body including in the heart and nervous system. Amino acid sequence analysis and over-expression studies indicate it is an ion channel that allows the transmembrane flux of small cations including sodium and calcium.
D J, Beech, S Z, Xu, D, McHugh, R, Flemming   +3 more
openaire   +2 more sources