Results 91 to 100 of about 4,899 (211)

Molecular alterations in high‐grade neuroendocrine tumors of the small intestine

The Journal of Pathology, Volume 268, Issue 2, Page 215-226, February 2026.
Abstract High‐grade neuroendocrine tumors of the small intestine are separated into two groups: well‐differentiated neuroendocrine tumors (NETs, high‐grade) and poorly differentiated neuroendocrine carcinomas (NECs). They represent very rare entities, with few molecular data available, and are very challenging to treat.
Agathe Hercent, Julien Masliah‐Planchon, David Cohen, Remy Nicolle, Jean‐Yves Scoazec, Philippe Ruszniewski, Ivan Bièche, Louis de Mestier, Anne Couvelard, Jerome Cros   +9 more
wiley   +1 more source

Corticolimbic expression of TRPC4 and TRPC5 channels in the rodent brain. [PDF]

PLoS ONE, 2007
The canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that are activated by increases in intracellular Ca(2+) and G(q)/phospholipase C-coupled receptors.
Melissa A Fowler, Kyriaki Sidiropoulou, Emin D Ozkan, Christopher W Phillips, Donald C Cooper   +4 more
doaj   +1 more source

Emerging Roles of Diacylglycerol-Sensitive TRPC4/5 Channels

Cells, 2018
Transient receptor potential classical or canonical 4 (TRPC4) and TRPC5 channels are members of the classical or canonical transient receptor potential (TRPC) channel family of non-selective cation channels.
Michael Mederos y Schnitzler, Thomas Gudermann, Ursula Storch   +2 more
doaj   +1 more source

Human TRPC5 structures reveal interaction of a xanthine-based TRPC1/4/5 inhibitor with a conserved lipid binding site

Communications Biology, 2020
Wright et al. report the first structure of a human TRPC1/4/5 channel in complex with a xanthine-based TRPC5 inhibitor Pico145. They find that Pico145 binds to a conserved lipid binding site of TRPC5, where it displaces a phospholipid.
David J. Wright, Katie J. Simmons, Rachel M. Johnson, David J. Beech, Stephen P. Muench, Robin S. Bon   +5 more
doaj   +1 more source

Using automated patch clamp electrophysiology platforms in pain-related ion channel research: insights from industry and academia [PDF]

, 2017
Automated patch clamp (APC) technology was first developed at the turn of the millennium. The increased throughput it afforded promised a new paradigm in ion channel recordings: it offered the potential to overcome the time-consuming, low-throughput ...
Alexander, Alexander, Alexander, Alexander, Alexandrou, Arias, Asmild, Bagal, Becker, Bridgland-Taylor, Brinkwirth, Brüggemann, Cao, Castle, Chambard, Chambers, Dale, Danker, Deuis, Dunlop, Dunlop, Enna, Estacion, Fertig, Finkel, Friis, Gilbert, Gillie, Golden, Hamill, Hao, Haraguchi, Haythornthwaite, Ji, Kahle, Kao, Kauthale, Klement, Klint, Knabl, Kornecook, Kumar, Kuryshev, Lepple-Wienhues, Lin, Mathes, Mathes, Mathie, Miller, Milligan, Obergrussberger, Obergrussberger, Papakosta, Payne, Perkel, Sakmann, Sauter, Scheel, Schroeder, Shcherbatko, Shcherbatko, Sorota, Southan, Southan, Spencer, Stannard, Stoelzle, Swensen, Tao, Terstappen, Tibbs, Trivedi, Vasilyev, Windley, Xie, Xu, Xu   +76 more
core   +1 more source

Implication of intracellular chloride channel in extracellular matrix remodeling in pressure‐overloaded mice and patients with dilated cardiomyopathy

Physiological Reports, Volume 14, Issue 1, January 2026.
Abstract Chloride intracellular channels (CLICs) are important in cardiac cellular physiology. We aimed to determine the pathophysiological roles of CLICs in the heart. For this, we analyzed CLIC expression in cardiomyocytes in a mouse transverse aortic constriction (TAC) model to induce cardiac hypertrophy and failure, as well as in ventricular ...
Gaku Oguri, Seitaro Nomura, Takafumi Nakajima, Hironobu Kikuchi, Syotaro Obi, Issei Komuro, Norihiko Takeda, Shigeru Toyoda, Toshiaki Nakajima   +8 more
wiley   +1 more source

Functional Cysteine Pair in TRPC5 Cation Channel

The FASEB Journal, 2008
Mammalian homologues of Drosophila TRP proteins form non‐selective cation channels in many cell types. One member of the canonical subfamily of TRP channels, TRPC5, is expressed in a range of tissues including parts of the brain and blood vessels.
Piruthivi Sukumar, Shang‐Zhong Xu, Fanning Zeng, Jing Li, Yahya M Bahnasi, Lin‐Hua Jiang, Asipu Sivaprasadarao, David J Beech   +7 more
openaire   +1 more source

TRPC channels regulate Ca2+-signaling and short-term plasticity of fast glutamatergic synapses.

PLoS Biology, 2019
Transient receptor potential (TRP) proteins form Ca2+-permeable, nonselective cation channels, but their role in neuronal Ca2+ homeostasis is elusive. In the present paper, we show that TRPC channels potently regulate synaptic plasticity by changing the ...
Yvonne Schwarz, Katharina Oleinikov, Barbara Schindeldecker, Amanda Wyatt, Petra Weißgerber, Veit Flockerzi, Ulrich Boehm, Marc Freichel, Dieter Bruns   +8 more
doaj   +1 more source

Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives

ChemPlusChem, Volume 90, Issue 12, December 10, 2025.
Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley   +1 more source

Development and Validation of Operant Cocaine Self-Administration in Rodents [PDF]

, 2011
Drug addiction is a debilitating psychiatric disorder characterized by compulsive drug seeking despite negative consequences. Due to its prevalence in our society, the development of reliable models to investigate its epidemiology is critical to ...
Pomrenze, Matthew
core   +2 more sources