Differential expression and hypoxic regulation of adenosine receptors and TRPC channels in the developing heart. [PDF]
, 2012 Objectives: To characterize the modifications of gene expression of adenosine receptors (AR), TRPC channels, HIF-1α and iNOS during the early cardiogenesis in response to chronic hypoxia exposure. Methods: 4-day-old chick embryos were subjected in ovo to
Carrupt, M.
core
CNS Neuroscience &Therapeutics, Volume 31, Issue 9, September 2025.T3 loss in congenital hypothyroidism (CH) downregulates TRPC6 in dentate granule cells (DGCs), which reduces dendritic spine density via the CaMKIV/CREB signaling pathway. TRPC6 agonist hyperforin rescues DGCs' dendritic spines and cognitive function of CH pups.
Tianci Li +10 more
wiley +1 more source
Identification of an N-terminal glycogen synthase kinase 3 phosphorylation site which regulates the functional localisation of polycystin-2 in vivo and in vitro [PDF]
, 2006 PKD2 is mutated in 15% of patients with autosomal dominant polycystic kidney disease (ADPKD). Polycystin-2 (PC2), the PKD2 protein, is a nonselective Ca2 + -permeable cation channel which may function at the cell surface and ER. Nevertheless, the factors
Kane, M.E. +4 more
core +2 more sources
Molecular Mechanisms of Chronic Pain and Therapeutic Interventions
MedComm, Volume 6, Issue 8, August 2025.We offer a comprehensive overview of the distinctive molecular mechanisms underlying nociceptive, neuropathic, and nociplastic pain, including the immune responses, ion channels, monoaminergic imbalance, and neuroinflammation. Subsequently, we summarized the status quo of nociceptive, neuropathic, and nociplastic pain managementmanipulation.
Zhen Li +8 more
wiley +1 more source
Inhibition of human TRPC5 activity by PIP2
The FASEB Journal, 2006 Phosphatidylinositol 4,5‐bisphosphate (PIP2) has important regulatory roles in many cellular process. Several members of the TRPM and TRPV ion channel families have been shown to be regulated by PIP2. Using a HEK293 cell line stably expressing human TRPC5, we tested whether the function of TRPC5 is also regulated by PIP2 ...
Fanning Zeng, Damian McHugh, David Beech
openaire +1 more source
Store depletion induces Gαq-mediated PLCβ1 activity to stimulate TRPC1 channels in vascular smooth muscle cells. [PDF]
, 2015 Depletion of sarcoplasmic reticulum (SR) Ca(2+) stores activates store-operated channels (SOCs) composed of canonical transient receptor potential (TRPC) 1 proteins in vascular smooth muscle cells (VSMCs), which contribute to important cellular functions.
Anthony P. Albert +5 more
core +2 more sources
Roles for Ca2+ mobilization and its regulation in mast cell functions: recent progress [PDF]
, 2016 Ca(2+)mobilization in response to cross-linking of IgE bound to its high affinity receptor, FcεRI, on mast cells is central to immune allergic responses.
Baird, B +3 more
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Romanian Journal of Laboratory MedicineChromosomal translocations, particularly X–autosome rearrangements, are rare and can produce complex clinical phenotypes even in carriers who appear phenotypically normal.
Yücel İlyas +7 more
doaj +1 more source
High glucose enhances store-operated calcium entry by upregulating ORAI/STIM via calcineurin-NFAT signalling [PDF]
, 2014 © 2014, Springer-Verlag Berlin Heidelberg. Abstract: ORAI and stromal interaction molecule (STIM) are store-operated channel molecules that play essential roles in human physiology through a coupling mechanism of internal Ca 2+ store to Ca 2+ influx ...
Atkin, Stephen L. +14 more
core +1 more source
TRP Channels: Current Perspectives in the Adverse Cardiac Remodeling [PDF]
, 2019 Calcium is an important second messenger required not only for the excitation-contraction coupling of the heart but also critical for the activation of cell signaling pathways involved in the adverse cardiac remodeling and consequently for the heart ...
Calderón Sánchez, Eva María +7 more
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