Structure-function study of ubiquitin c-terminal hydrolase L1 (UCH-L1) by NMR spectroscopy - insights into UCH-L1 mutation's association with the risk of Parkinson's disease [PDF]
, 2012 Poster Presentation: P72Protein ubiquitination and deubiquitination, play important roles in many aspects of cellular mechanisms. Its defective regulation results in diseases that range from developmental abnormalities to neurodegenerative diseases and ...
Hu, HY, Sze, KH, Tse, HS
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Identification of key structural elements for neuronal calcium sensor-1 function in the regulation of the temperature-dependency of locomotion in C. elegans [PDF]
, 2013 BACKGROUND: Intracellular Ca(2+) regulates many aspects of neuronal function through Ca(2+) binding to EF hand-containing Ca(2+) sensors that in turn bind target proteins to regulate their function.
Barclay, Jeff W +4 more
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Pharmacological ResearchSphingolipids are critical components of cellular membranes that play a pivotal role in modulating ion channel function by forming lipid rafts that stabilize and localize these channels.
Junliang Wan +11 more
doaj +1 more source
Expression and function of transient receptor potential channels in the female bovine reproductive tract [PDF]
, 2016 © 2016 Elsevier Inc. The epithelium lining the oviduct is critical for early reproductive events, many of which are mediated via intracellular calcium ions.
Atkin, Stephen L. +3 more
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Frontiers in Plant Science, 2015 In order to identify channels involved in membrane depolarization, Ulva compressa was incubated with agonists of TRP channels C5, A1 and V1 and the level of intracellular calcium was detected.
Melissa eGómez +4 more
doaj +1 more source
Sphingosine-1-phosphate-induced nociceptor excitation and ongoing pain behavior in mice and humans is largely mediated by S1P3 receptor [PDF]
, 2013 The biolipid sphingosine-1-phosphate (S1P) is an essential modulator of innate immunity, cell migration, and wound healing. It is released locally upon acute tissue injury from endothelial cells and activated thrombocytes and, therefore, may give rise to
Andratsch, Manfred +11 more
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Regulatory role of proheparanase with peri-synaptic heparan sulfate proteoglycan and AMPA-type glutamate receptor in synaptic plasticity [PDF]
, 2012 Poster Presentation: P59AMPA-type glutamate receptors (AMPAR) govern excitatory synaptic transmission. Perineuronal heparan sulfates (HS) have been implicated in controlling the open-state of AMPAR.
Cham, WC +4 more
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Neuroprotective effects of Lycium barbarum polysaccharides against rat hippocampal apoptosis induced by chronic intermittent hypoxia [PDF]
, 2012 Poster presentationWe have shown neuronal apoptosis in the hippocampus of rats exposed to chronic intermittent hypoxia mimicking severe conditions of obstructive sleep apnea (OSA) syndrome in patients [1].
Fung, ML, Lam, CS, Tipoe, GL
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Ionic Mechanisms of Spinal Neuronal Cold Hypersensitivity in Ciguatera [PDF]
, 2015 Cold hypersensitivity is evident in a range of neuropathies and can evoke sensations of paradoxical burning cold pain. Ciguatoxin poisoning is known to induce a pain syndrome caused by consumption of contaminated tropical fish that can persist for months
Brice, NL +3 more
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A role for TRPC5 in cold sensing, finally [PDF]
Pflügers Archiv - European Journal of Physiology, 2021 openaire +3 more sources