Results 81 to 90 of about 4,899 (211)
Emerging Roles of L-Type Voltage-Gated and Other Calcium Channels in T Lymphocytes [PDF]
, 2013 In T lymphocytes, calcium ion controls a variety of biological processes including development, survival, proliferation, and effector functions. These distinct and specific roles are regulated by different calcium signals, which are generated by various ...
Abdallah eBadou +4 more
core +2 more sources
FEBS Open Bio, Volume 16, Issue 3, Page 520-531, March 2026.Light activation of the photoswitchable cannabinoid ligand azo‐HU308 triggers Ca2+ influx in pancreatic β‐cells through TRPC channels, independent of CB2 cannabinoid receptors. This reveals a non‐GPCR pathway for cannabinoid modulation of β‐cell Ca2+ dynamics and establishes azo‐HU308 as an optical tool to study cannabinoid signaling through TRP ...
Alexander E. G. Viray, James A. Frank
wiley +1 more source
Potential Treatment for Neuropsychiatry Disorders with TRPC5 Modulators [PDF]
ACS Medicinal Chemistry Letters, 2016 Patent Application Title: Quinazoline-2,4(1H,3H)-dione Derivatives as TRPC5 Modulators for the Treatment of Neuropsychiatry Disorders Patent Application Number: WO 2016/023826 Al Publication date: 18 February 2016 Priority Application: US 62/035,578 Priority date: 11 August 2014 Inventors: Chenard, B. L.; Gallaschun, R. J. Applicants: Hydra Biosciences,
openaire +2 more sources
TrpC5 Mediates Acute Leptin and Serotonin Effects via Pomc Neurons
Cell Reports, 2017 The molecular mechanisms underlying acute leptin and serotonin 2C receptor-induced hypophagia remain unclear. Here, we show that neuronal and pro-opiomelanocortin (Pomc)-specific loss of transient receptor potential cation 5 (TrpC5) subunits is ...
Yong Gao +15 more
doaj +1 more source
Clemizole and La3+ salts ameliorate angiotensin II‐induced glomerular hyperpermeability in vivo
Physiological Reports, 2021 Angiotensin II (Ang II) induces marked, dynamic increases in the permeability of the glomerular filtration barrier (GFB) in rats. After binding to its receptor, Ang II elicits Ca2+ influx into cells, mediated by TRPC5 and TRPC6 (transient receptor ...
Julia Dolinina +2 more
doaj +1 more source
Interaction of ARF-1.1 and neuronal calcium sensor-1 in the control of the temperature-dependency of locomotion in Caenorhabditis elegans [PDF]
, 2016 Neuronal calcium sensor-1 (NCS-1) mediates changes in cellular function by regulating various target proteins. Many potential targets have been identified but the physiological significance of only a few has been established.
Barclay, JW +4 more
core +1 more source
Acta Physiologica, Volume 242, Issue 3, March 2026.ABSTRACT Aim The glomerulus is a specialized microvascular unit that filters plasma through the coordinated function of podocytes and parietal epithelial cells (PECs). From this perspective, the glomerulus functions like a living hydrogeological filtration system.
Maria Elena Melica +3 more
wiley +1 more source
TRPC Channels in Proteinuric Kidney Diseases
Cells, 2019 Over a decade ago, mutations in the gene encoding TRPC6 (transient receptor potential cation channel, subfamily C, member 6) were linked to development of familial forms of nephrosis. Since this discovery, TRPC6 has been implicated in the pathophysiology
Gentzon Hall +2 more
doaj +1 more source
A role of canonical transient receptor potential 5 channel in neuronal differentiation from A2B5 neural progenitor cells. [PDF]
PLoS ONE, 2010 Store-operated Ca(2+) entry (SOCE) channels are the main pathway of Ca(2+) entry in non-excitable cells such as neural progenitor cells (NPCs). However, the role of SOCE channels has not been defined in the neuronal differentiation from NPCs.
Hye Young Shin +9 more
doaj +1 more source
Thermosensing ability of TRPC5: current knowledge and unsettled questions. [PDF]
J Physiol SciOur understanding of how the mammalian somatosensory system detects noxious cold is still limited. While the role of TRPM8 in signaling mild non-noxious coolness is reasonably understood, the molecular identity of channels transducing painful cold stimuli remains unresolved.
Ptakova A, Vlachova V.
europepmc +3 more sources