Results 71 to 80 of about 4,899 (211)

Deletion of diacylglycerol-responsive TRPC genes attenuates diabetic nephropathy by inhibiting activation of the TGFβ1 signaling pathway [PDF]

, 2017
TRPC6 plays a critical role in proteinuric kidney diseases, and TRPC3 is involved in tubulointerstitialdamage and renal fibrosis in obstructed kidneys. Podocyte loss is a characteristic event in diabetic nephropathy(DN).
Birnbaumer, Lutz, He, Xiju, Li, Shoutian, Liao, Yanhong, Liu, Benju, Xu, Benke   +5 more
core  

An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Na(v)1.6 in peripheral pain pathways [PDF]

, 2013
Cold allodynia, pain in response to cooling, occurs during or within hours of oxaliplatin infusion and is thought to arise from a direct effect of oxaliplatin on peripheral sensory neurons.
Abrahamsen, Adelsberger, Alloui, Almeida, Argyriou, Attal, Bautista, Benoit, Burgess, Caldwell, Carr, Cersosimo, Colburn, Cox, de la Pena, Descoeur, Dhaka, Ehrsson, Fischer, Frankenhaeuser, Gauchan, Graham, Grolleau, Hensel, Jong, Kagiava, Krishnan, Leo, Ling, Liu, Luo, Madrid, Maingret, Nassini, Park, Peier, Rasband, Reid, Renn, Rush, Sakurai, Schafer, Schiavon, Shields, Sittl, Sittl, Story, Takeshita, Teichert, Vetter, Vetter, Viana, Wilson, Xiao, Yu, Zamudio, Zhang, Zhao, Zimmermann, Zimmermann   +59 more
core   +1 more source

Potential health benefits of cold‐water immersion: the central role of PGC‐1α

The Journal of Physiology, EarlyView.
Abstract figure legend Cold‐water immersion (CWI) elicits autonomic, somato‐motoric (shivering thermogenesis), endocrine and metabolic, sensory transduction, and local biophysical effects that may converge on the transcriptional co‐activator PGC‐1α (centre).
Erich Hohenauer, Wafa Douzi, Johannes Burtscher   +2 more
wiley   +1 more source

Downregulation of TRPC4 and TRPC5 Inhibits Smooth Muscle Cell Proliferation without Affecting Endothelial Cell Proliferation

Genetics Research, 2021
Aims. The main treatment for coronary heart disease is percutaneous coronary intervention (PCI), and drug-eluting stents are designed to inhibit vascular smooth muscle cell (VSMCs) proliferation and migration causing restenosis by releasing ...
Wenjun Zeng, Yinan Ji, Haiping Zhang, Liusheng Chen, Li Du, Ruiwei Guo   +5 more
doaj   +1 more source

TRPC6 counteracts TRPC3-Nox2 protein complex leading to attenuation of hyperglycemia-induced heart failure in mice [PDF]

, 2017
Excess production of reactive oxygen species (ROS) caused by hyperglycemia is a major risk factor for heart failure. We previously reported that transient receptor potential canonical 3 (TRPC3) channel mediates pressure overload-induced maladaptive ...
Birnbaumer, Lutz, Harada, Eri, Ishikawa, Tatsuya, Kitajima, Naoyuki, Kumagai, Yoshito, Nishida, Motohiro, Nishimura, Akiyuki, Numaga Tomita, Takuro, Oda, Sayaka, Shimauchi, Tsukasa, Tomizaki, Takashi   +10 more
core   +1 more source

Drafting the calmodulation playbook: Emerging structural insights into transient receptor potential channel regulation by calmodulin

The Journal of Physiology, EarlyView.
Abstract figure legend Calmodulin (CaM) is a ubiquitous calcium (Ca2+) sensor that translates intracellular Ca2+ signals into modulation of hundreds of effector proteins including ion channels. CaM is increasingly recognized as a key regulator of the transient receptor potential (TRP) channel family, yet the underlying ‘calmodulation playbook’ is only ...
Aden M. Alemayhu, Candice E. Paulsen
wiley   +1 more source

RXR Gamma Enables Oligodendrocyte Differentiation by Suppressing Sonic Hedgehog Signaling

Glia, Volume 74, Issue 6, June 2026.
Using pharmacogenetic approaches, Baldassarro et al. demonstrate that RXRγ suppresses the SHH signaling pathway in OPCs to ensure their efficient differentiation following T3 stimulation. Accordingly, Rxrg−/− OPCs displayed compromised differentiation which was normalized by the pharmacological inhibition of the hyperactive SHH pathway.
Vito Antonio Baldassarro, Quentin Brassart, Valérie Fraulob, Laura Calzà, Wojciech Krezel   +4 more
wiley   +1 more source

Analysis of the Effect of the TRPC4/TRPC5 Blocker, ML204, in Sucrose-Induced Metabolic Imbalance

Pharmaceuticals, 2023
Sugar-induced metabolic imbalances are a major health problem since an excessive consumption of saccharides has been linked to greater obesity rates at a global level.
Mizael C. Araújo, Suzany H. S. Soczek, Jaqueline P. Pontes, Bruno A. S. Pinto, Lucas M. França, Bruna da Silva Soley, Gabriela S. Santos, Warlison F. de Silva Saminez, Fernanda K. M. Fernandes, João L. do Carmo Lima, Daniele Maria-Ferreira, João F. S. Rodrigues, Nara L. M. Quintão, Valério Monteiro-Neto, Antônio M. A. Paes, Elizabeth S. Fernandes   +15 more
doaj   +1 more source

Transient receptor potential canonical 4 and 5 proteins as targets in cancer therapeutics [PDF]

, 2016
Novel approaches towards cancer therapy are urgently needed. One approach might be to target ion channels mediating Ca²+ entry because of the critical roles played by Ca²+ in many cell types, including cancer cells.
A Arcangeli, A Fleckenstein, A Riccio, B Kumar, B Minke, B Vannier, B Zeng, C Carson, C Sourbier, C Strubing, CE Paulsen, CX Bai, CY Kuang, D Veliceasa, David J. Beech, DD McKemy, DE Clapham, DJ Beech, E Al-Shawaf, F Antigny, F Zheng, GR Monteith, H Wei, Hannah J. Gaunt, HB Song, HN Jiang, J Abramowitz, J Li, JC Herve, JM Richter, JM Richter, KD Phelan, KN Westlund, L Birnbaumer, L Radtke, M Liao, M Miller, M Tominaga, MC Mohl, MJ Berridge, N Damann, N Prevarskaya, Naveen S. Vasudev, NS Vasudev, P Sukumar, PC Yu, PD Wes, PK Flemming, R Ratnayake, RS Bon, S Jung, S Orrenius, SE Jordt, SZ Xu, SZ Xu, SZ Xu, T Schaldecker, T Wang, TA Stewart, V Caropreso, VV Tsvilovskyy, X Ma, X Ma, X Ma, Y Akbulut, Y Majeed, YF Chen, YR Park   +67 more
core   +2 more sources

TRP canonical 4 and/or 5 channel inhibition reduces aversion‐ and increases reward‐responding in chronically stressed mice

British Journal of Pharmacology, Volume 183, Issue 9, Page 2139-2165, May 2026.
Abstract Background and Purpose Pharmacological inhibition of TRPC4 and/or TRPC5 channels reduces Pavlovian aversion memory in stressed mice and reduces amygdala reactivity to aversion in humans with depression. The aims of this mouse study were to improve understanding of these anxiolytic processes, determine whether there are corrective effects on ...
Giulia Poggi, Deniz Queisser, Alena Senn, Hannes Sigrist, Diana Kúkeľová, Lorraine Madur, Nagiua Cuomo‐Haymour, Mélisse Robert, Sophie Schmid, Adrián Portalés, Sophie Simard, Naguib Mechawar, Bastian Hengerer, Stefan Just, Christopher R. Pryce   +14 more
wiley   +1 more source