Results 51 to 60 of about 4,899 (211)

Treatment with HC-070, a potent inhibitor of TRPC4 and TRPC5, leads to anxiolytic and antidepressant effects in mice. [PDF]

PLoS ONE, 2018
Forty million adults in the US suffer from anxiety disorders, making these the most common forms of mental illness. Transient receptor potential channel canonical subfamily (TRPC) members 4 and 5 are non-selective cation channels highly expressed in ...
Stefan Just, Bertrand L Chenard, Angelo Ceci, Timothy Strassmaier, Jayhong A Chong, Nathaniel T Blair, Randall J Gallaschun, Donato Del Camino, Susan Cantin, Marc D'Amours, Christian Eickmeier, Christopher M Fanger, Carsten Hecker, David P Hessler, Bastian Hengerer, Katja S Kroker, Sam Malekiani, Robert Mihalek, Joseph McLaughlin, Georg Rast, JoAnn Witek, Achim Sauer, Christopher R Pryce, Magdalene M Moran   +23 more
doaj   +1 more source

Molecular Sensors and Modulators of Thermoreception [PDF]

, 2015
Peer ...
Zhang, Xuming
core   +1 more source

(-)-Englerin A-evoked Cytotoxicity is Mediated by Na+ Influx and Counteracted by Na+/K+-ATPase [PDF]

, 2016
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing Transient Receptor Potential Canonical 4 protein (TRPC4).
Akbulut, Alevizopoulos, Alfonso, Carson, Dietrich, Engl, Fash, Kim, Li, López-Suárez, Naylor, Plant, Radtke, Rajasekaran, Ratnayake, Reinhold, Schaefer, Selvakumar, Shankavaram, Shi, Sourbier, Storch, Strübing, Xu   +23 more
core   +1 more source

RNA-Seq Analysis of Broiler Liver Transcriptome Reveals Novel Responses to High Ambient Temperature [PDF]

, 2014
In broilers, high ambient temperature can result in reduced feed consumption, digestive inefficiency, impaired metabolism, and even death. The broiler sector of the U.S.
Ashwell, Chris, Coble, Derrick, Fleming, Damarius, Lamont, Susan, Lamont, Susan, Persia, Michael, Rothschild, Max, Rothschild, Max, Schmidt, Carl   +8 more
core   +3 more sources

Hypoosmotic‐ and pressure‐induced membrane stretch activate TRPC5 channels [PDF]

The Journal of Physiology, 2008
Transient receptor potential (TRP) channels mediate a wide array of sensory functions. We investigated the role of TRPC5, a poorly characterized channel widely expressed in the central and peripheral nervous system, as a potential osmosensory protein. Here we show that hypoosmotic stimulation activates TRPC5 channels resulting in a large calcium influx.
Gomis, Ana, Soriano, Sergio, Belmonte, Carlos, Viana, Félix   +3 more
openaire   +3 more sources

Hypothalamic Vitamin D Improves Glucose Homeostasis and Reduces Weight [PDF]

, 2016
Despite clear associations between vitamin D deficiency and obesity and/or type 2 diabetes, a causal relationship is not established. Vitamin D receptors (VDRs) are found within multiple tissues, including the brain.
Arble, Deanna M., Chambers, Adam P., Gardner, David, Gutierrez-Aguilar, Ruth, He, Yanlin, Moore, David D., Sandoval, Darleen A., Seeley, Randy J., Sisley, Stephanie R., Xu, Yong   +9 more
core   +4 more sources

Transient Receptor Potential Canonical 5 (TRPC5): Regulation of Heart Rate and Protection against Pathological Cardiac Hypertrophy

Biomolecules
TRPC5 is a non-selective cation channel that is expressed in cardiomyocytes, but there is a lack of knowledge of its (patho)physiological role in vivo.
Pratish Thakore, James E. Clark, Aisah A. Aubdool, Dibesh Thapa, Anna Starr, Paul A. Fraser, Keith Farrell-Dillon, Elizabeth S. Fernandes, Ian McFadzean, Susan D. Brain   +9 more
doaj   +1 more source

TRPC5 expression promotes the proliferation and invasion of papillary thyroid carcinoma through the HIF-1α/Twist pathway

Translational Oncology
Objective: This study aimed to investigate the effect of TRPC5 on PTC (papillary thyroid carcinoma) proliferation and invasion. Methods: Immunofluorescence and western blot were used to evaluate the expression of TRPC5 in paraffin sections and clinical ...
Jing Yang, Yue Cheng, Yan Nie, Bole Tian, Jing Huang, Rixiang Gong, Zhihui Li, Jingqiang Zhu, Yanping Gong   +8 more
doaj   +1 more source

Cocaine self-administration in mice with forebrain knock-down of trpc5 ion channels [v1; ref status: indexed, http://f1000r.es/pb]

F1000Research, 2013
Canonical transient receptor potential (TRPC) channels are a family of non-selective cation channels that play a crucial role in modulating neuronal excitability due to their involvement in intracellular Ca2+ regulation and dendritic growth.
Matthew B Pomrenze, Michael V Baratta, Kristin C Rasmus, Brian A Cadle, Shinya Nakamura, Lutz Birnbaumer, Donald C Cooper   +6 more
doaj   +1 more source

Blockade of TRPC Channels Limits Cholinergic-Driven Hyperexcitability and Seizure Susceptibility After Traumatic Brain Injury

Frontiers in Neuroscience, 2021
We investigated the contribution of excitatory transient receptor potential canonical (TRPC) cation channels to posttraumatic hyperexcitability in the brain 7 days following controlled cortical impact model of traumatic brain injury (TBI) to the parietal
Chase M. Carver, Haley R. DeWitt, Aiola P. Stoja, Mark S. Shapiro   +3 more
doaj   +1 more source